Davercin
- CAS No.
- 55224-05-0
- Chemical Name:
- Davercin
- Synonyms
- Erythromycin Cyclocarbonate;erythromycin A cyclic 11,12-carbonate;CWE;DAVERCIN;Dravercin;Davercin USP/EP/BP;Erythromycin cycloester;Davercin, 10 mM in DMSO;Eritromicina A carbonato;Erythromycin Impurity 10
- CBNumber:
- CB2966540
- Molecular Formula:
- C38H65NO14
- Molecular Weight:
- 759.93
- MDL Number:
- MFCD28348360
- MOL File:
- 55224-05-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >135°C (dec.) |
|---|---|
| Boiling point | 859.8±65.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| pka | 13.49±0.70(Predicted) |
| form | Solid |
| color | White |
| FDA UNII | 4H3125L82R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Toxicity | LD50 oral in rat: 5800mg/kg |
Davercin price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21348 | Davercin ≥98% | 55224-05-0 | 1mg | $74 | 2026-04-30 | Buy |
| Cayman Chemical | 21348 | Davercin ≥98% | 55224-05-0 | 5mg | $219 | 2026-04-30 | Buy |
| Cayman Chemical | 21348 | Davercin ≥98% | 55224-05-0 | 10mg | $366 | 2026-04-30 | Buy |
| Cayman Chemical | 21348 | Davercin ≥98% | 55224-05-0 | 25mg | $821 | 2026-04-30 | Buy |
| TRC | TRC-E650045-5MG | Erythromycin Cyclocarbonate | 55224-05-0 | 5mg | $262 | 2026-06-03 | Buy |
Davercin Chemical Properties, Uses, Production
Description
Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 μg/ml). Davercin is non-toxic to mice and rats (LD50s = 4.05 and 5.9 g/kg, respectively). Formulations containing davercin have been used to treat a variety of urogenital bacterial infections.
Uses
Davercin (erythromycin A cyclic 11,12-carbonate) is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.
Uses
Erythromycin Cyclocarbonate is a derivative of Erythromycin (E649950), an antibcterial agent working on the 50S ribosomal subunit.
Definition
ChEBI: Davercin is an aminoglycoside.
References
[1] H BOJARSKA-DAHLIG. L-aspartate of erythromycin A cyclic 11,12-carbonate, a new semisynthetic erythromycin derivative.[J]. Journal of Antibiotics, 1976, 29 9: 907-914. DOI: 10.7164/antibiotics.29.907
Davercin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| BeiJing TOP Science Bio-Technology Co., Ltd. | +86-13439059536 +86-15201677815 | 2638315663@qq.com | China | 292 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Target molecule Corp. | 857-239-0968 | service1@targetmol.com | United States | 2548 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
View Latest Price from Davercin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Davercin
55224-05-0
|
$39.00-89.00 | 98.73% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-02-02 | Davercin
55224-05-0
|
$1.00 | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-09-03 | Davercin
55224-05-0
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
