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YM-53601

YM-53601 Structure
YM-53601 structure
CAS No.
182959-33-7
Chemical Name:
YM-53601
Synonyms
YM-53601 Exclusive;YM-53601 hydrochloride;(E)-2-(2-Fluoro-2-(quinuclidin-3-ylidene)ethoxy)-9H-carbazole hydrochloride;2-[(2E)-2-(1-azabicyclo[2.2.2]octan-3-ylidene)-2-fluoroethoxy]-9H-carbazole:hydrochloride;2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride;9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1)
CBNumber:
CB2972954
Molecular Formula:
C21H21FN2O.ClH
Molecular Weight:
372.869
MDL Number:
MFCD06411577
MOL File:
182959-33-7.mol
Last updated:2025-10-24 08:46:22
Product description Number Pack Size Price
YM-53601 ≥98% 18113 500μg $207
YM-53601 ≥98% 18113 1mg $388
YM-53601 ≥98% 18113 5mg $1631
2-((2E)-2-(1-AZABICYCLO(2.2.2)OCT-3-YLIDENE)-2-FLUOROETHOXY)-9H-CARBAZOLE, MONOHYDROCHLORIDE 95.00% INB0005643 5MG $657
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YM-53601 Properties

Melting point 236.5-237.2 °C
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 2 mg/ml
form A crystalline solid
color Off-white to light brown
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25

YM-53601 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18113 YM-53601 ≥98% 182959-33-7 500μg $207 2024-03-01 Buy
Cayman Chemical 18113 YM-53601 ≥98% 182959-33-7 1mg $388 2024-03-01 Buy
Cayman Chemical 18113 YM-53601 ≥98% 182959-33-7 5mg $1631 2024-03-01 Buy
American Custom Chemicals Corporation INB0005643 2-((2E)-2-(1-AZABICYCLO(2.2.2)OCT-3-YLIDENE)-2-FLUOROETHOXY)-9H-CARBAZOLE, MONOHYDROCHLORIDE 95.00% 182959-33-7 5MG $657 2021-12-16 Buy
Product number Packaging Price Buy
18113 500μg $207 Buy
18113 1mg $388 Buy
18113 5mg $1631 Buy
INB0005643 5MG $657 Buy

YM-53601 Chemical Properties,Uses,Production

Uses

YM-53601 is a squalene synthetase inhibitor.

Definition

ChEBI: YM-53601 is a member of carbazoles.

Biological Activity

Squalene synthase inhibitor.


YM-53601 is a cell penetrant and potent squalene synthase inhibitor inhibits cholesterol biosynthesis in rodents. YM-53601 lowers cholesterol levels and triglyceride levels better than HMG-CoA reductase inhibitor (prevastatin) and fibrate (fenofibrate.).

in vivo

YM-53601 suppresses cholesterol biosynthesis in rats (ED50, 32?mg/kg)[1].
YM-53601 also reduces plasma non-HDL cholesterol levels in hamsters by approximately 70% at an oral dose of 50 mg/kg/day for 5 days[2].
YM-53601 potentiates Doxorubicin-mediated hepatocellular carcinoma cells (HCC) growth arrest and cell death in vivo[4].

Animal Model:Sprague-Dawley (SD) rats weighing 150-170?g[1]
Dosage:6.25, 12.5, 25 or 50?mg/kg
Administration:Given a single p.o.
Result:Inhibited cholesterol biosynthesis from acetate in a dose-dependent manner in rats. The ED50?value for YM-53601 cholesterol biosynthesis inhibition is 32? mg/kg.
Animal Model:Five- to six-week-old male BALB/c athymic (nu/nu) nude mice[4]
Dosage:15 mg/kg
Administration:2 wk of daily treatment by p.o. gavage
Result:Significantly decreased the intratumor cholesterol levels.

YM-53601 Preparation Products And Raw materials

Raw materials

Preparation Products

YM-53601 Suppliers

Global( 33)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 18272 56
BOC Sciences 16314854226 info@bocsci.com United States 9923 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57422 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Suzhou Chenrui Biotechnology Co. LTD 17625585511 1580084073@qq.com China 931 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
ChemStrong Scientific Co.,Ltd 56
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Hongye Biotechnology Co. Ltd 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Suzhou Chenrui Biotechnology Co. LTD 58

View Lastest Price from YM-53601 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
YM-53601 pictures 2025-10-23 YM-53601
182959-33-7
 US $163.00 / mg 99.65% 10g TargetMol Chemicals Inc.
  • YM-53601 pictures
  • YM-53601
    182959-33-7
  • US $163.00 / mg
  • 99.65%
  • TargetMol Chemicals Inc.

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2-[(2E)-2-(1-azabicyclo[2.2.2]octan-3-ylidene)-2-fluoroethoxy]-9H-carbazole:hydrochloride 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride YM-53601 Exclusive 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1) (E)-2-(2-Fluoro-2-(quinuclidin-3-ylidene)ethoxy)-9H-carbazole hydrochloride YM-53601 hydrochloride 182959-33-7 C21H21FN2OHCl