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ChemicalBook >> CAS DataBase List >>6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide Structure
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide structure
CAS No.
371942-69-7
Chemical Name:
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide
Synonyms
s1219;CS-335;YM 201636;YM201636 HCl;YM201636, >=98%;PIKfyve Inhibitor;YM201636/YM-201636;YM-201636, 10 mM in DMSO;YM-201636 YM201636 PIKfyve Inhibitor;6-amino-N-(3-(4-morpholinopyrido[3,,2,:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)nicotinamide
CBNumber:
CB22484860
Molecular Formula:
C25H21N7O3
Molecular Weight:
467.48
MDL Number:
MFCD16038303
MOL File:
371942-69-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:04:43
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6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide Properties

Melting point >226°C (dec.)
Density 1.446
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Very Slightly)
form Solid
color Pale Beige to Light Beige
InChIKey YBPIBGNBHHGLEB-UHFFFAOYSA-N
SMILES N6(CCOCC6)c1nc(nc4c1[o]c5ncccc54)c2cc(ccc2)NC(=O)c3cnc(cc3)N
CAS DataBase Reference 371942-69-7
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 1
Storage Class 11 - Combustible Solids

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13576 YM-201636 ≥95% 371942-69-7 1mg $55 2026-04-30 Buy
Cayman Chemical 13576 YM-201636 ≥95% 371942-69-7 5mg $215 2026-04-30 Buy
Cayman Chemical 13576 YM-201636 ≥95% 371942-69-7 10mg $322 2026-04-30 Buy
ChemScene CS-0592 YM-201636 98.05% 371942-69-7 2mg $79 2026-06-04 Buy
ChemScene CS-0592 YM-201636 98.05% 371942-69-7 5mg $135 2026-06-04 Buy
Product number Packaging Price Buy
13576 1mg $55 Buy
13576 5mg $215 Buy
13576 10mg $322 Buy
CS-0592 2mg $79 Buy
CS-0592 5mg $135 Buy

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide Chemical Properties,Uses,Production

Uses

YM 201636 is a phosphatidylinositol phosphate kinase PIP5KIII (PIKfyve) inhibitor and significantly reduces the survival of primary mouse hippocampal neurons in culture. YM-201636 treatment increases the level of the autophagosomal marker protein LC3-II.

Definition

ChEBI: 6-amino-N-[3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenyl]-3-pyridinecarboxamide is an aromatic amide.

General Description

A cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 = 33 nM and >5 μM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against p110α (IC50 = 3.3 μM) and little activity against type IIγ PtdInsP kinase even at concentrations as high as 10 μM. Shown to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular endosomal transport in a reversible manner.

Biological Activity

ym201636 is a potent, selective and cell-permeable inhibitor of mammalian class iii phosphatidylinositol phosphate kinase pikfyve with ic50 value of 33nm [1].the pyridofuropyrimidine compound, ym201636, is a small-molecule inhibitor of pikfyve. in the in vitro assay, it inhibits pikfyve with ic50 value of 33nm and shows no inhibition of yeast orthologue of pikfyve. it inhibits ptdins3p p110α and type iα ptdinsp kinase with ic50 values of 3μm and > 2μm, respectively. the type iiγ ptdinsp kinase is found to be insensitive to ym201636. in serum-starved nih3t3 cells, ym201636 inhibits ptdins (3, 5) p2 production by 80% at concentration of 800nm. acute treatment of ym201636 to mefs, mdck, mcf10a, cos7 and nih3t3 cells causes the formation of large vesicular structures. besides that, ym201636 is also found to reduce the akt phosphorylation and glut4 cell surface translocation through inhibiting the insulin-dependent class i pi 3k activation [1, 2].

IC 50

PIKfyve: 33 nM (IC50); p110α: 3.3 μM (IC50); Autophagy

References

[1] jefferies h b j, cooke f t, jat p, et al. a selective pikfyve inhibitor blocks ptdins (3, 5) p2 production and disrupts endomembrane transport and retroviral budding. embo reports, 2008, 9(2): 164-170.
[2] ikonomov o c, sbrissa d, shisheva a. ym201636, an inhibitor of retroviral budding and pikfyve-catalyzed ptdins (3, 5) p2synthesis, halts glucose entry by insulin in adipocytes. biochemical and biophysical research communications, 2009, 382(3): 566-570.

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide Suppliers

Global( 171)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Shangchem Co., Ltd. +86-21-68182121 China 881 52
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Xi’an chemsoar Medical Technology Co., ltd 029-86538357 China 234 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
China Kouting Group Limited +86 (21) 5811-6473 5811-6475 sales@koutingchina.com China 494 60
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
Shangchem Co., Ltd. 52
Jinan Trio PharmaTech Co., Ltd. 62
Xi’an chemsoar Medical Technology Co., ltd 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Dalian Meilun Biotech Co., Ltd. 58
NCE Biomedical Co.,Ltd. 55
China Kouting Group Limited 60
Haoyuan Chemexpress Co., Ltd. 61

View Lastest Price from 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide pictures 2019-07-06 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide
371942-69-7
 $2.00 1kg 99% 100kg Career Henan Chemical Co

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide Spectrum

6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide(371942-69-7)1HNMR

371942-69-7(6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide)Related Search:

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6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide YM 201636 YM201636/YM-201636 3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]- CS-335 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide YM201636 YM 201636 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide YM201636, >=98% YM201636 HCl 6-amino-N-(3-(4-morpholinopyrido[3,,2,:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)nicotinamide 3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2- 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide USP/EP/BP 6-amino-N-(3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)nicotinamide hydrochloride YM-201636 YM201636 PIKfyve Inhibitor s1219 6-Amino-N-(3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)nicotinamide YM-201636, 10 mM in DMSO PIKfyve Inhibitor 371942-69-7 71942-69-7 C25H21N7O3ClH C24H19N7O3 Inhibitors