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YM17E

YM17E Structure
YM17E structure
CAS No.
124900-72-7
Chemical Name:
YM17E
Synonyms
YM17E;YM17E, 10 mM in DMSO;1,1'-(1,3-Phenylenebis(methylene))bis(1-cycloheptyl-3-(4-(dimethylamino)phenyl)urea);Urea, N,N''-[1,3-phenylenebis(methylene)]bis[N-cycloheptyl-N'-[4-(dimethylamino)phenyl]- (9CI);Diglyceride acyltransferase,Inhibitor,acyl-CoA:cholesterol acyltransferase,inhibit,YM17E,Acyltransferase,Diacylglycerol acyltransferase,mono- acylglycerol acyltransferase,YM-17E
CBNumber:
CB01346334
Molecular Formula:
C40H56N6O2
Molecular Weight:
652.93
MDL Number:
MOL File:
124900-72-7.mol
MSDS File:
SDS
Last updated:2026-07-14 16:49:18
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YM17E Properties

Boiling point 862.7±65.0 °C(Predicted)
Density 1.16±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka 14.03±0.70(Predicted)
color White to off-white

YM17E price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth ZEA90072 YM17E 124900-72-7 1mg $1215.48 2026-06-05 Buy
Biosynth ZEA90072 YM17E 124900-72-7 5mg $3435.1 2026-06-05 Buy
Biosynth ZEA90072 YM17E 124900-72-7 10mg $5496 2026-06-05 Buy
Biosynth ZEA90072 YM17E 124900-72-7 25mg $10305.3 2026-06-05 Buy
Biosynth ZEA90072 YM17E 124900-72-7 50mg $16488.5 2026-06-05 Buy
Product number Packaging Price Buy
ZEA90072 1mg $1215.48 Buy
ZEA90072 5mg $3435.1 Buy
ZEA90072 10mg $5496 Buy
ZEA90072 25mg $10305.3 Buy
ZEA90072 50mg $16488.5 Buy

YM17E Chemical Properties, Uses, Production

Uses

YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC50 of 44 nM in rabbit liver microsomes in vitro.

Biological Activity

YM17E is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50 of 44 nM in vitro in rabbit liver microsomes.

in vitro

YM17E is as potent in inhibiting ACAT activity in the liver as in the intestine, with IC 50 values of 45 and 34 nM, respectively.

in vivo

YM17E (3, 10 and 30 mg/kg per day, p.o.) decreases total cholesterol, cholesteryl ester and non-HDL cholesterol in a dose-dependent manner. Total cholesterol and cholesteryl ester levels in liver do not decrease significantly after intravenous administration of YM17E, but do decrease significantly and in a dose-dependent manner after oral administration. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats after both oral and intravenous administration[1]. YM17E inhibits production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources[2].

target

IC50: 44 nM (ACAT in rabbit liver microsomes)

References

[1] Uchida T, et al. Relationship between bioavailability and hypocholesterolemic activity of YM17E, an inhibitor of ACAT, in cholesterol-fed rats. Atherosclerosis. 1998 Mar;137(1):97-106. DOI:10.1016/s0021-9150(97)00259-1
[2] Kashiwa M, et al. Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol. 1997 Jan;73(1):41-50. DOI:10.1254/jjp.73.41

YM17E Preparation Products And Raw materials

Raw materials

Preparation Products

YM17E Suppliers

Global Suppliers ( 25)
Supplier Tel Email Country ProdList Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9792 55
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-13601744364 13601744364 chemsharker@126.com China 1159 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Supplier Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
cjbscvictory 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from YM17E manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
YM17E pictures 2026-07-14 YM17E
124900-72-7
 $53.00-128.00 99.29% 10g TargetMol Chemicals Inc.
YM17E pictures 2026-07-14 YM17E
124900-72-7
 $53.00-128.00 99.29% 10g TargetMol Chemicals Inc.
  • YM17E pictures
  • YM17E
    124900-72-7
  • $53.00-128.00
  • 99.29%
  • TargetMol Chemicals Inc.
  • YM17E pictures
  • YM17E
    124900-72-7
  • $53.00-128.00
  • 99.29%
  • TargetMol Chemicals Inc.

YM17E Spectrum

YM17E(124900-72-7)1HNMR

124900-72-7 (YM17E) Related Search:

5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline YM155 YM 26734 1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride BTP2
Ethyl 4-(2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl)piperazine-1-carboxylate YM-53601 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide

1of2

YM17E Urea, N,N''-[1,3-phenylenebis(methylene)]bis[N-cycloheptyl-N'-[4-(dimethylamino)phenyl]- (9CI) Diglyceride acyltransferase,Inhibitor,acyl-CoA:cholesterol acyltransferase,inhibit,YM17E,Acyltransferase,Diacylglycerol acyltransferase,mono- acylglycerol acyltransferase,YM-17E 1,1'-(1,3-Phenylenebis(methylene))bis(1-cycloheptyl-3-(4-(dimethylamino)phenyl)urea) YM17E, 10 mM in DMSO 124900-72-7 C40H56N6O2