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ChemicalBook >> CAS DataBase List >>L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]-

L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]-

L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- Structure
L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- structure
CAS No.
18921-73-8
Chemical Name:
L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]-
Synonyms
861;SK-29861;SK 29861;Ccnsc529;Ccnsc-529;Ccnsc 529;Chlorasquin;Ccnsc529,861;Ccnsc-529,861;Ccnsc 529,861
CBNumber:
CB310634331
Molecular Formula:
C20H19ClN6O5
Molecular Weight:
458.86
MDL Number:
MFCD01664838
MOL File:
18921-73-8.mol
MSDS File:
SDS
Last updated:2026-05-11 19:39:08
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L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- Properties

Density 1.603±0.06 g/cm3(Predicted)
pka 3.19±0.10(Predicted)
FDA UNII 4REQ59Y97R

L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- Chemical Properties, Uses, Production

Uses

Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents[1][2].

References

[1] Chello PL, et al. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists. Cancer Res. 1976 Jul;36(7 PT 1):2442-9. PMID:1277151
[2] Hynes J B, et al. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids[J]. Journal of Medicinal Chemistry, 1977, 20(4): 588-591. DOI:10.1021/jm00214a030

L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chlorasquin pictures 2026-05-11 Chlorasquin
18921-73-8
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • Chlorasquin pictures
  • Chlorasquin
    18921-73-8
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

18921-73-8 (L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]-) Related Search:

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Methasquin

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L-Aspartic acid, N-[4-[[(2,4-diamino-5-chloro-6-quinazolinyl)methyl]amino]benzoyl]- 861 Ccnsc 529 Ccnsc529 Ccnsc-529 Chlorasquin SK 29861 SK-29861 Ccnsc 529,861 Ccnsc529,861 Ccnsc-529,861 18921-73-8