5-Aminothiazole-4-carboxylic acid ethyl ester
- CAS No.
- 18903-18-9
- Chemical Name:
- 5-Aminothiazole-4-carboxylic acid ethyl ester
- Synonyms
- Ethyl 5-aminothiazole-4-carboxylate;2-Pyrrolidinone,6-(hydroxymethyl)-;Ethyl 5-aMino-1,3-thiazole-4-carboxylate;5-Aminothiazole-4-carboxylic acid ethyl ester;4-Thiazolecarboxylic acid, 5-aMino-, ethyl ester;ethyl 5-aminothiazole-4-carboxylate hydrochloride
- CBNumber:
- CB31113317
- Molecular Formula:
- C6H8N2O2S
- Molecular Weight:
- 172.2
- MDL Number:
- MFCD09834584
- MOL File:
- 18903-18-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| ETHYL 5-AMINOTHIAZOLE-4-CARBOXYLATE 97% | 50176 | 1G | $24 |
| ETHYL 5-AMINOTHIAZOLE-4-CARBOXYLATE 97% | 50176 | 5G | $111 |
| ETHYL 5-AMINOTHIAZOLE-4-CARBOXYLATE 97% | 50176 | 25G | $527 |
| Ethyl 5-amino-1,3-thiazole-4-carboxylate 97% | OR51950 | 100mg | $21 |
| Ethyl 5-amino-1,3-thiazole-4-carboxylate 97% | OR51950 | 250mg | $24 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H335-H319-H302 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| HS Code | 2934100090 |
5-Aminothiazole-4-carboxylic acid ethyl ester price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 50176 | ETHYL 5-AMINOTHIAZOLE-4-CARBOXYLATE 97% | 18903-18-9 | 1G | $24 | 2026-04-30 | Buy |
| AstaTech | 50176 | ETHYL 5-AMINOTHIAZOLE-4-CARBOXYLATE 97% | 18903-18-9 | 5G | $111 | 2026-04-30 | Buy |
| AstaTech | 50176 | ETHYL 5-AMINOTHIAZOLE-4-CARBOXYLATE 97% | 18903-18-9 | 25G | $527 | 2026-04-30 | Buy |
| Apolloscientific | OR51950 | Ethyl 5-amino-1,3-thiazole-4-carboxylate 97% | 18903-18-9 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR51950 | Ethyl 5-amino-1,3-thiazole-4-carboxylate 97% | 18903-18-9 | 250mg | $24 | 2026-06-04 | Buy |
5-Aminothiazole-4-carboxylic acid ethyl ester Chemical Properties,Uses,Production
Synthesis Reference(s)
Tetrahedron, 41, p. 5989, 1985 DOI: 10.1016/S0040-4020(01)91439-5
Synthesis
1759-25-7
18903-18-9
Synthesis of compound 16c: Preparation of ethyl 5-aminothiazole-4-carboxylate: compound 16b (9.0 g, 58 mmol) was suspended in toluene (200 ml). Lawesson's reagent (23.0 g, 58 mmol, 1 eq.) was added at once. The resulting yellow suspension was stirred overnight at 70 °C and under N2 atmosphere. Upon completion of the reaction, the mixture was cooled to 0°C and the toluene layer was poured from the colloidal material at the bottom of the flask and washed with aqueous 1N hydrochloric acid (6 x 50 ml). The colloidal material was dissolved in methanol (150 ml) and subsequently concentrated under reduced pressure. The residue (brown oily substance) was suspended in tert-butyl methyl ether (TBME, 300 ml) and washed with 1N aqueous hydrochloric acid (1 x 300 ml, 2 x 100 ml). The aqueous portions were combined and alkalized with 2N aqueous sodium hydroxide (460 ml) followed by extraction with ethyl acetate (EtOAc, 1 x 300 ml, 2 x 200 ml and 1 x 100 ml). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product ethyl 5-aminothiazole-4-carboxylate (7 g). The crude product was purified by column chromatography (silica gel, heptane-ethyl acetate, 1/1) to afford compound 16c (6 g, 35 mmol, 60% yield) as a brown solid.1H-NMR (300 MHz, CDCl3) δ 7.89 (s, 1H), 6.04 (bs, 2H), 4.42 (q, 2H, J=7Hz), 1.43 (t, 3H) J=7Hz).
References
[1] Patent: WO2008/59368, 2008, A2. Location in patent: Page/Page column 66-68
[2] Patent: WO2014/33630, 2014, A1. Location in patent: Page/Page column 50
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3774 - 3780
[4] Nucleosides and Nucleotides, 1995, vol. 14, # 3-5, p. 313 - 316
[5] Chemical and Pharmaceutical Bulletin, 1971, vol. 19, p. 119 - 123
5-Aminothiazole-4-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Hefei Hangang Pharmaceutical Technology Co., Ltd. | +8618062405514 | ada@ipurechemical.com | China | 10224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 |
View Lastest Price from 5-Aminothiazole-4-carboxylic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | JANUS BLACK
18903-18-9
|
$1.00 | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- JANUS BLACK
18903-18-9
- $1.00
- 98%
- Career Henan Chemical Co
18903-18-9(5-Aminothiazole-4-carboxylic acid ethyl ester)Related Search:
1of3
