Phthalazin-5-amine
- CAS No.
- 102072-84-4
- Chemical Name:
- Phthalazin-5-amine
- Synonyms
- 5-Phthalazinamine;Phthalazin-5-amine;5-AMINO-PHTHALAZINE;Quinoxalin-5-ylamine;5-Aminophthalazine - [A72106]
- CBNumber:
- CB7173949
- Molecular Formula:
- C8H7N3
- Molecular Weight:
- 145.16
- MDL Number:
- MFCD08272072
- MOL File:
- 102072-84-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
Phthalazin-5-amine price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR907050 | 5-Aminophthalazine 98% | 102072-84-4 | 100mg | $56 | 2026-06-04 | Buy |
| Apolloscientific | OR907050 | 5-Aminophthalazine 98% | 102072-84-4 | 250mg | $81 | 2026-06-04 | Buy |
| Apolloscientific | OR907050 | 5-Aminophthalazine 98% | 102072-84-4 | 1g | $172 | 2026-06-04 | Buy |
| Activate Scientific | AS30342 | 5-Aminophthalazine 95% | 102072-84-4 | 1g | $270 | 2026-06-04 | Buy |
| Activate Scientific | AS30342 | 5-Aminophthalazine 95% | 102072-84-4 | 5g | $890 | 2026-06-04 | Buy |
Phthalazin-5-amine Chemical Properties, Uses, Production
Uses
5-Aminophthalazine is a building block that was used as a reactant in the synthetic preparation of ezrin inhibitors targeting metastatic osteosarcoma.
Synthesis
89898-86-2
102072-84-4
General procedure for the synthesis of 5-amino phthalazine using 5-nitro phthalazine as starting material: 0.88 g (5.0 mmol) of 5-nitro phthalazine was dissolved in 30 mL of tetrahydrofuran at 50 °C, followed by the addition of 4.37 g (25.1 mmol) of sodium bisulfite dissolved in a solution of 15 mL of water. The reaction mixture was stirred continuously at 50 °C for 15 min. Upon completion of the reaction, the organic phase was extracted with ethyl acetate (3 x 100 mL) and the combined organic phases were washed with brine (50 mL) and dried with anhydrous magnesium sulfate. After filtration, the solvent was removed by concentration under reduced pressure to give the crude product as a bright yellow precipitate. The crude product was recrystallized in hot methanol to give 0.49 g (67% yield) of purified 5-aminophthalazine. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100.17 MHz, DMSO-d6) as follows: 1H NMR δ: 9.80 (s, 1H), 9.60 (s, 1H), 7.60 (dd, J = 4.6, 7.6 Hz, 1H), 7.20 (dd, J = 1.9, 4.6 Hz, 1H), 7.02 (d, J = 7.6 Hz, 1H), 6.50 (s, 2H); 13C NMR δ: 150.1,146.5,145.1,133.2,126.1,114.7,114.1,112.2.
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 8, p. 1329 - 1340
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 478 - 487
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 744 - 752
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2577 - 2580
[5] Patent: US2006/116368, 2006, A1. Location in patent: Page/Page column 35; 36
Phthalazin-5-amine Preparation Products And Raw materials
Phthalazin-5-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4908 | 55 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
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