2,3-Dibromoquinoline
- CAS No.
- 13721-00-1
- Chemical Name:
- 2,3-Dibromoquinoline
- Synonyms
- 2,3-Dibromoquinoline;Quinoline, 2,3-dibromo-
- CBNumber:
- CB3113448
- Molecular Formula:
- C9H5Br2N
- Molecular Weight:
- 286.95
- MDL Number:
- MFCD00234472
- MOL File:
- 13721-00-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H302-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P |
| HazardClass | IRRITANT |
2,3-Dibromoquinoline price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 273090 | 2,3-Dibromoquinoline Asreported | 13721-00-1 | 250mg | $619 | 2026-06-03 | Buy |
| Usbiological | 273090 | 2,3-Dibromoquinoline Asreported | 13721-00-1 | 500mg | $807 | 2026-06-03 | Buy |
| Usbiological | 273090 | 2,3-Dibromoquinoline Asreported | 13721-00-1 | 1g | $1133 | 2026-06-03 | Buy |
| Usbiological | 273090 | 2,3-Dibromoquinoline Asreported | 13721-00-1 | 2g | $1649 | 2026-06-03 | Buy |
| Usbiological | 273090 | 2,3-Dibromoquinoline Asreported | 13721-00-1 | 5g | $2761 | 2026-06-03 | Buy |
2,3-Dibromoquinoline Chemical Properties, Uses, Production
Application
2,3-Dibromoquinoline is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.
Synthesis
5332-24-1
13721-00-1
General procedure for the synthesis of 2,3-dibromoquinoline from 3-bromoquinoline: To a stirred solution of 3-bromoquinoline (306 mg, 1.47 mmol) in dichloromethane (3 mL) was added m-chloroperoxybenzoic acid (m-CPBA, 358 mg, 85% max, 1.76 mmol) at 0 °C and the reaction was stirred overnight at room temperature. Additional dichloromethane (11.6 mL) was added to the reaction mixture. Phosphorus tribromide oxide (POBr3, 516 mg, 1.76 mmol) was added to the resulting solution at 0 °C, followed by dropwise addition of N,N-dimethylformamide (DMF, 57 μL, 0.74 mmol) under argon protection. The reaction mixture was gradually warmed to 25 °C and stirred for 2 h, after which additional dichloromethane (10 mL) was added. Saturated aqueous sodium carbonate solution was slowly added to the reaction mixture and the pH was adjusted to 7-8. The resulting mixture was separated and the aqueous phase was thoroughly extracted with dichloromethane. The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (petroleum ether: ethyl acetate = 100:1) to afford 2,3-dibromoquinoline (335 mg, 79% yield) as a white solid.
References
[1] Tetrahedron, 2016, vol. 72, # 38, p. 5762 - 5768
[2] Organic Letters, 2007, vol. 9, # 26, p. 5525 - 5528
2,3-Dibromoquinoline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai yirong biology science and technology co., ltd | 18049974220 | 3060526242@qq.com | China | 999 | 60 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. | 02161555100 | China | 820 | 58 | |
| Shanghai Kahn Pharmaceutical Co., Ltd. | 021-34979681; 17701870669 | 41513101@qq.com | China | 1786 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Civic Chemical Technology Co., Ltd. | 021-34053660 | sale2@labgogo.com | China | 2018 | 58 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
| Shanghai Baozhi Biological Technology Co., Ltd. | 13764058804 | 3438424070@qq.com | China | 384 | 58 |
