3-Bromoquinoline
- CAS No.
- 5332-24-1
- Chemical Name:
- 3-Bromoquinoline
- Synonyms
- Bromoquinoline;Quinoline, 3-bromo-;NSC 3995;CETH-016;3-BromoquinoL;3-BROMOQUINOLINE;3-BROMOQUINLIINE;3-bromo-quinolin;3-Bromoquuinoline;1-3-Bromoquinoline
- CBNumber:
- CB4220082
- Molecular Formula:
- C9H6BrN
- Molecular Weight:
- 208.05
- MDL Number:
- MFCD00006767
- MOL File:
- 5332-24-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 13-15 °C (lit.) |
|---|---|
| Boiling point | 274-276 °C (lit.) |
| Density | 1.533 g/mL at 25 °C (lit.) |
| vapor pressure | 0.196Pa at 25℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.69(at 25℃) |
| form | Liquid |
| color | Clear colorless to yellow |
| Water Solubility | 103mg/L at 25℃ |
| BRN | 112939 |
| InChI | 1S/C9H6BrN/c10-8-5-7-3-1-2-4-9(7)11-6-8/h1-6H |
| InChIKey | ZGIKWINFUGEQEO-UHFFFAOYSA-N |
| SMILES | Brc1cnc2ccccc2c1 |
| LogP | 3.03 |
| CAS DataBase Reference | 5332-24-1(CAS DataBase Reference) |
| FDA UNII | ZRP57JF73Z |
| NIST Chemistry Reference | Quinoline, 3-bromo-(5332-24-1) |
| EPA Substance Registry System | Quinoline, 3-bromo- (5332-24-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| RIDADR | UN2810 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29334900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
3-Bromoquinoline price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 124133 | 3-Bromoquinoline 98% | 5332-24-1 | 25g | $131 | 2026-04-30 | Buy |
| Sigma-Aldrich | 124133 | 3-Bromoquinoline 98% | 5332-24-1 | 100g | $262.5 | 2026-04-30 | Buy |
| TCI Chemical | B1013 | 3-Bromoquinoline >98.0%(GC)(T) | 5332-24-1 | 25g | $86 | 2026-04-30 | Buy |
| Usbiological | 262039 | 3-Bromoquinoline Asreported | 5332-24-1 | 5g | $275 | 2026-06-03 | Buy |
| Usbiological | 262039 | 3-Bromoquinoline Asreported | 5332-24-1 | 10g | $362 | 2026-06-03 | Buy |
3-Bromoquinoline Chemical Properties, Uses, Production
Preparation
3-Bromoquinoline reacts with mixed acids to form 3-bromo-5-nitroquinoline, which is then oxidized to 5-bromo-2,3-pyridinedicarboxylic acid upon heating with potassium permanganate. 6-Bromoquinoline reacts with nitric acid upon heating to form 6-bromo-8-nitroquinoline, which is then oxidized to 2,3-pyridinedicarboxylic acid upon reaction with potassium permanganate. 2-Bromoquinoline is prepared by reacting 2-hydroxyquinoline with phosphorus pentabromide. 3-Bromoquinoline is prepared by heating quinoline perbromide at 180°C. 4-Bromoquinoline is prepared by heating 4-hydroxyquinoline with phosphorus pentabromide, or by diazotizing 4-aminoquinoline. 5-Bromoquinoline is prepared by heating m-bromoaniline, glycerol, m-bromonitrobenzene, and concentrated sulfuric acid, or by diazotizing 5-aminoquinoline. 6-Bromoquinoline is prepared by heating p-bromoaniline with glycerol, concentrated sulfuric acid, and p-bromonitrobenzene. 7-Bromoquinoline is prepared by diazotization of 7-aminoquinoline. 8-Bromoquinoline is prepared by heating o-bromoaniline, glycerol, concentrated sulfuric acid, and o-bromonitrobenzene. Uses: As a reagent in organic synthesis.
Bromoquinoline
There are seven position isomers with the main properties are as follows:
(2399.79Pa)
Application and synthesis method
3-Bromoquinoline can have action with mixed acid to generate 3-bromo-5-nitroquinoline, followed by heating with potassium permanganate to be oxidized to 5-bromo-2, 3-pyridine dicarboxylic acid.
6-bromo-quinoline can be heated together nitric acid to generate 6-bromo-8-nitro-quinoline, followed by reaction with potassium permanganate to be oxidized into 2, 3-pyridinedicarboxylic acid.
2-bromo-quinoline can be manufactured through the reaction between 2-hydroxyquinoline and phosphorus pentabromide
3-bromo-quinoline can be obtained through heating the quinoline perbromide at 180 ° C.
4-bromoquinoline can be obtained through either the heating reaction between 4-hydroxyquinoline and phosphorus pentabromide or by the diazotization reaction of 4-aminoquinoline.
5-bromo-quinoline can be obtained from the heating reaction between m-bromo aniline, glycerol, m-bromonitrobenzene and concentrated sulfuric acid, or through the diazotization reaction of 5-amino-quinoline.
6-bromo-quinoline can be obtained through the heating reaction between p-bromoaniline, glycerol, concentrated sulfuric acid and p-bromo-nitrobenzene.
7-bromoquinoline can be obtained through the diazotization of 7-aminoquinoline.
8-bromo-quinoline can be obtained through the heating of o-bromo aniline, glycerol, concentrated sulfuric acid and o-bromo-nitrobenzene in the heating system.
Purposes: as organic synthesis reagents.
Uses
For pharmaceuticals
Medicine, pesticide intermediates
Chemical Properties
colorless to light yellow liquid
Uses
3-Bromoquinoline undergoes bromine-magnesium exchange reaction with lithium tributylmagnesate in toluene at -10°C, which is quenched by various electrophiles to yield functionalized quinolines.
Synthesis Reference(s)
The Journal of Organic Chemistry, 27, p. 1318, 1962 DOI: 10.1021/jo01051a047
General Description
3-Bromoquinoline undergoes bromine-magnesium exchange reaction with lithium tributylmagnesate in toluene at -10°C, which is quenched by various electrophiles to yield functionalized quinolines.
Flammability and Explosibility
Not classified
References
[1] Patent: US3956301, 1976, A
[2] Patent: US5266700, 1993, A
3-Bromoquinoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei Jiete Pharmaceutical Technology Co., Ltd | 0551-18256521115 18256521115 | 2788434637@qq.com | China | 32 | 58 |
| Hubei zhonglong Kangsheng Fine Chemical Co., Ltd | 027-83850381 18171045381 | 2533797015@qq.com | China | 991 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 3-Bromoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | 3-Bromoquinoline
5332-24-1
|
$11.00-119.00 | 25g | 0.98 | 25kg | Shanghai UCHEM Inc. | |
 |
2026-08-20 | 3-Bromoquinoline
5332-24-1
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | 3-Bromoquinoline
5332-24-1
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 3-Bromoquinoline
5332-24-1
- $11.00-119.00
- 0.98
- Shanghai UCHEM Inc.
-
- 3-Bromoquinoline
5332-24-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-Bromoquinoline
5332-24-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
