N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
- CAS No.
- 1177141-67-1
- Chemical Name:
- N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
- Synonyms
- CKI-7 Dihydrochloride;CKI-7 2HCL;CKI-7 dihydrochlorid;CKI-7, 10 mM in DMSO;CKI-7 (hydrochloride);CKI-7 dihydrochloride[C0742];N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride;N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride;Serum and glucocorticoid-regulated kinase,inhibit,nestin,S6K,Inhibitor,CK1,Casein Kinase,Ribosomal S6 Kinase (RSK),differentiation,SGK,CKI-7,Cyclin dependent kinase,neural,Serum-glucocorticoid regulated kinase,S6K1,MSK1,CDK,CKI 7,Wnt,CKI7,βIII-tubulin,Sox1
- CBNumber:
- CB31176497
- Molecular Formula:
- C11H14Cl3N3O2S
- Molecular Weight:
- 358.67176
- MDL Number:
- MFCD00897689
- MOL File:
- 1177141-67-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 187-189°C |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: >5mg/mL |
| form | solid |
| color | white to light tan |
| Water Solubility | H2O: >5mg/mL |
| InChI | 1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H |
| InChIKey | JUAVTXYOCISSSL-UHFFFAOYSA-N |
| SMILES | Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C0742 | CKI-7 dihydrochloride ≥98% (HPLC), solid | 1177141-67-1 | 5mg | $233 | 2026-04-30 | Buy |
| Sigma-Aldrich | C0742 | CKI-7 dihydrochloride ≥98% (HPLC), solid | 1177141-67-1 | 25mg | $973 | 2026-04-30 | Buy |
| Cayman Chemical | 28268 | CKI-7 (hydrochloride) ≥98% | 1177141-67-1 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 28268 | CKI-7 (hydrochloride) ≥98% | 1177141-67-1 | 5mg | $178 | 2026-04-30 | Buy |
| Cayman Chemical | 28268 | CKI-7 (hydrochloride) ≥98% | 1177141-67-1 | 10mg | $259 | 2026-04-30 | Buy |
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Chemical Properties, Uses, Production
Chemical Properties
Beige Solid
Uses
Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases
Biochem/physiol Actions
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.
in vivo
In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death[2].
IC 50
CK1: 6 μM (IC50); p70S6K; CK1: 8.5 μM (Ki); Cdc7; SGK; MSK1
storage
Store at -20°C
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189;18621755571 | mychess007@163.com | China | 1994 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14571 | 60 |
