- CKI-7
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- $30.00
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2026-09-10
- CAS:1177141-67-1
- Purity: 100.00%
- Supply Ability: 10g
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| | N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Basic information |
| Product Name: | N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride | | Synonyms: | N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride;CKI-7 dihydrochlorid;N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride;CKI-7 2HCL;Serum and glucocorticoid-regulated kinase,inhibit,nestin,S6K,Inhibitor,CK1,Casein Kinase,Ribosomal S6 Kinase (RSK),differentiation,SGK,CKI-7,Cyclin dependent kinase,neural,Serum-glucocorticoid regulated kinase,S6K1,MSK1,CDK,CKI 7,Wnt,CKI7,βIII-tubulin,Sox1;CKI-7 (hydrochloride);CKI-7, 10 mM in DMSO;CKI-7 dihydrochloride[C0742] | | CAS: | 1177141-67-1 | | MF: | C11H14Cl3N3O2S | | MW: | 358.67176 | | EINECS: | | | Product Categories: | Inhibitors;Protein Kinase Inhibitors and Activators;All Inhibitors | | Mol File: | 1177141-67-1.mol |  |
| | N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Chemical Properties |
| Melting point | 187-189°C | | storage temp. | -20°C | | solubility | H2O: >5mg/mL | | form | solid | | color | white to light tan | | Water Solubility | H2O: >5mg/mL | | InChI | 1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H | | InChIKey | JUAVTXYOCISSSL-UHFFFAOYSA-N | | SMILES | Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Usage And Synthesis |
| Chemical Properties | Beige Solid | | Uses | Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases | | Biochem/physiol Actions | CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM. | | in vivo | In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death[2]. | | IC 50 | CK1: 6 μM (IC50); p70S6K; CK1: 8.5 μM (Ki); Cdc7; SGK; MSK1 | | storage | Store at -20°C |
| | N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride Preparation Products And Raw materials |
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