Intoplicine
- CAS No.
- 125974-72-3
- Chemical Name:
- Intoplicine
- Synonyms
- Intoplicine;7H-Benzo[e]pyrido[4,3-b]indol-3-ol, 11-[[3-(dimethylamino)propyl]amino]-8-methyl-;11-(3-Dimethylaminopropylamino)-3-hydroxy-8-methyl-7H-benzo[e]pyrido[4,3-b]indole
- CBNumber:
- CB31178956
- Molecular Formula:
- C21H24N4O
- Molecular Weight:
- 348.44
- MDL Number:
- MFCD00866361
- MOL File:
- 125974-72-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Intoplicine 98.36% | CS-6640 | 5mg | $672 |
| Intoplicine 98.36% | CS-6640 | 10mg | $1105 |
| Intoplicine 98.36% | CS-6640 | 25mg | $2221 |
| Intoplicine 98.36% | CS-6640 | 50mg | $3575 |
| Intoplicine 98.36% | CS-6640 | 100mg | $5741 |
| Melting point | 216-218 °C |
|---|---|
| Boiling point | 635.5±55.0 °C(Predicted) |
| Density | 1.286±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 8.26±0.30(Predicted) |
| color | White to off-white |
| NCI Dictionary of Cancer Terms | intoplicine |
| FDA UNII | FB2CIN6HMI |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Intoplicine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6640 | Intoplicine 98.36% | 125974-72-3 | 5mg | $672 | 2026-06-04 | Buy |
| ChemScene | CS-6640 | Intoplicine 98.36% | 125974-72-3 | 10mg | $1105 | 2026-06-04 | Buy |
| ChemScene | CS-6640 | Intoplicine 98.36% | 125974-72-3 | 25mg | $2221 | 2026-06-04 | Buy |
| ChemScene | CS-6640 | Intoplicine 98.36% | 125974-72-3 | 50mg | $3575 | 2026-06-04 | Buy |
| ChemScene | CS-6640 | Intoplicine 98.36% | 125974-72-3 | 100mg | $5741 | 2026-06-04 | Buy |
Intoplicine Chemical Properties,Uses,Production
Uses
Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA[1][2].
Definition
ChEBI: Intoplicine is a pyridoindole.
in vivo
At the highest non-toxic dose (HNTD) (6 mg/kg/injection, total dose, 36 mg/kg), Intoplicine shows highly active with a T/C of 0% and a corresponding total log cell kill of 3[3].
IC 50
Topoisomerase I; Topoisomerase II
References
[1] Eckardt JR, et al. Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994 Jan 5;86(1):30-3. DOI:10.1093/jnci/86.1.30
[2] Morjani H, et al. Molecular and cellular interactions between Intoplicine, DNA, and topoisomerase II studied by surface-enhanced Raman scattering spectroscopy. Cancer Res. 1993 Oct 15;53(20):4784-90. PMID:8402662
[3] Bissery MC, et al. Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice. Invest New Drugs. 1993;11(4):263-277. DOI:10.1007/BF00874425
Intoplicine Preparation Products And Raw materials
Raw materials
Preparation Products
Intoplicine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49945 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2123 | 70 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7751 | 56 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24957 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 10000 | 58 |
