Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-

2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-

2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Structure
2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- structure
CAS No.
2286257-25-6
Chemical Name:
2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-
Synonyms
2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-
CBNumber:
CB312280488
Molecular Formula:
C18H19FN2O2
Molecular Weight:
314.35
MDL Number:
MOL File:
2286257-25-6.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24
Request For Quotation

2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Properties

Boiling point 497.9±45.0 °C(Predicted)
Density 1.269±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMF: 15 mg/ml,DMSO: 2 mg/ml,Ethanol: 2 mg/ml
form A crysalline solid
pka 16.07±0.20(Predicted)

2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 33166 C3 ≥98% 2286257-25-6 1mg $81 2026-04-30 Buy
Cayman Chemical 33166 C3 ≥98% 2286257-25-6 5mg $218 2026-04-30 Buy
Cayman Chemical 33166 C3 ≥98% 2286257-25-6 10mg $395 2026-04-30 Buy
Product number Packaging Price Buy
33166 1mg $81 Buy
33166 5mg $218 Buy
33166 10mg $395 Buy

2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Chemical Properties, Uses, Production

Uses

MAO-B-IN-33 (compound C3) is a potent, reversible and selective monoamine oxidase-B (MAO-B) inhibitor with an IC50 of 0.021 μM and 26.805 μM for MAO-B and MAO-A, respectively. The selectivity of MAO-B-IN-33 is attributed to the steric clash arising from the residue differences between Phe208 (MAO-A) and Ile199 (MAO-B). MAO-B-IN-33 inhibits cerebral MAO-B activity and alleviates MPTP (HY-15608)-induced dopaminergic neuronal loss in the mouse. MAO-B-IN-33 has the potential for Parkinson's disease research[1].

Biological Activity

C3 is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 0.021 μM).1 It is selective for MAO-B over MAO-A (IC50 = 26.8 μM). C3 (0.1, 1, and 3 mg/kg) prevents MPTP-induced decreases in brain dopamine levels in mice.

IC 50

MAO-B: 0.021 μM (IC50); MAO-A: 26.805 μM (IC50)

References

1.Jin, C.-F., Wang, Z.-Z., Chen, K.-Z., et al.Computational fragment-based design facilitates discovery of potent and selective monoamine oxidase-B (MAO-B) inhibitorJ. Med. Chem.63(23)15021-15036(2020)

2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Suppliers

Global Suppliers ( 4)
Supplier Tel Email Country ProdList Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

2286257-25-6 (2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-) Related Search:

GPR39-C3 2-Hexadecanol, 1,1′-[[3-[4-[2-[[3-[bis(2-hydroxyhexadecyl)amino]-2-ethoxypropyl](2-hydroxyhexadecyl)amino]ethyl]-1-piperazinyl]-2-ethoxypropyl]imino]bis- PalMaruMycin C3 Palmitic acid-1,2,3,4-13C4 C3 BODIPY Ganglioside GM1 (d18:1/3:0) ammonium salt
GSK-LSD1 Dihydrochloride

1of2

2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- 2286257-25-6