Senicapoc
- CAS No.
- 289656-45-7
- Chemical Name:
- Senicapoc
- Synonyms
- Senicapoc;ICA 17043;Senicapoc - Bio-X ?;Senicapoc (ICA17043);Senicapoc, 10 mM in DMSO;ICA-17043;ICA 17043;ICA17043;2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-
- CBNumber:
- CB31261049
- Molecular Formula:
- C20H15F2NO
- Molecular Weight:
- 323.34
- MDL Number:
- MFCD09027349
- MOL File:
- 289656-45-7.mol
Melting point | 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2)) |
---|---|
Boiling point | 460.7±45.0 °C(Predicted) |
Density | 1.250±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO : 50 mg/mL (154.64 mM; Need ultrasonic) |
form | Powder |
pka | 15.41±0.50(Predicted) |
color | White to yellow |
InChI | InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) |
InChIKey | SCTZUZTYRMOMKT-UHFFFAOYSA-N |
SMILES | C(C1C=CC=CC=1)(C1C=CC(F)=CC=1)(C1C=CC(F)=CC=1)C(=O)N |
FDA UNII | TS6G201A6Q |
UNSPSC Code | 12352200 |
NACRES | NA.77 |
Senicapoc price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML2500 | Senicapoc ≥98% (HPLC) | 289656-45-7 | 5 mg | $99.75 | 2025-07-31 | Buy |
Sigma-Aldrich | SML2500 | Senicapoc ≥98% (HPLC) | 289656-45-7 | 25 mg | $423 | 2025-07-31 | Buy |
Cayman Chemical | 29679 | Senicapoc | 289656-45-7 | 100mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 29679 | Senicapoc | 289656-45-7 | 1g | $426 | 2024-03-01 | Buy |
Cayman Chemical | 29679 | Senicapoc | 289656-45-7 | 50mg | $32 | 2024-03-01 | Buy |
Senicapoc Chemical Properties,Uses,Production
Description
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.
Uses
Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.
Definition
Senicapoc (ICA-17043; bis(4-fluorophenyl)phenyl acetamide), a selective, highly potent Gardos channel blocker (IC50 = 11 nM), specifically inhibits the efflux of potassium from the RBCs of both SCD transgenic mice and human sickle cell disease patients. It is derived from clotrimazole-1, a KCNN4 inhibitor. Senicapoc is well tolerated by both healthy volunteers and patients with SCD and has favourable pharmacokinetics, with a long half-life permitting once-daily dosing. It was designed for long-term sickle cell disease therapy to avoid clotrimazole-1 side effects. Whereas Senicapoc is a potent inhibitor of WT KCNN4, its efficiency on mutated channels was unknown[1-2].
in vivo
ICA-17043 (10 mg/kg, p.o.) administration produces a significant decrease in Gardos channel activity measured at day 11 and 21 and is associated with a corresponding increase in red cell K+ content without changes in Na+ content. ICA-17043 (10 mg/kg, twice a day) induces a significant increase in Hct after 11 days of dosing in the SAD mouse[1]. Senicapoc (30 mg/kg, p.o.) reduces airway hyperresponsiveness, eosinophil numbers in bronchoalveolar lavage taken 48 hours post-allergen challenge, and vascular remodelling in the sheep[2].
References
[1] Raphael Rapetti-Mauss. “Senicapoc: a potent candidate for the treatment of a subset of hereditary xerocytosis caused by mutations in the Gardos channel.” Haematologica 101 11 (2016): e431–e435.
[2] Kenneth I Ataga. “Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia.” Blood (2008): 3991–7.
Senicapoc Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 302 | 58 |
Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12151 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9236 | 58 |
View Lastest Price from Senicapoc manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2025-09-22 | Senicapoc
289656-45-7
|
US $32.00-79.00 / mg | 99.50% | 10g | TargetMol Chemicals Inc. | ||
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2025-08-21 | Senicapoc
289656-45-7
|
US $0.00-0.00 / MG | 10MG | 99.0%min. HPLC | 10000 | HangZhou RunYan Pharma Technology Co.,LTD. | |
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2021-07-13 | Senicapoc
289656-45-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |