osthenol
- CAS No.
- 484-14-0
- Chemical Name:
- osthenol
- Synonyms
- 7-Hydroxy-8-prenylcoumarin;7-Hydroxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one;NSC 625328;Osthenol, 10 mM in DMSO;7-Hydroxy-8-isopentenyl-2H-1-benzopyran-2-one;7-Hydroxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 7-hydroxy-8-(3-methyl-2-buten-1-yl)-;inhibit,selective,Monoamine Oxidase,MAO,depression,competitive,Osthenol,Inhibitor,coumarin,Ostenol
- CBNumber:
- CB31312338
- Molecular Formula:
- C14H14O3
- Molecular Weight:
- 230.26
- MDL Number:
- MFCD03427690
- MOL File:
- 484-14-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 89-91 °C |
|---|---|
| Boiling point | 422.8±45.0 °C(Predicted) |
| Density | 1.203±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 8.45±0.20(Predicted) |
| color | White to yellow |
| InChI | InChI=1S/C14H14O3/c1-9(2)3-6-11-12(15)7-4-10-5-8-13(16)17-14(10)11/h3-5,7-8,15H,6H2,1-2H3 |
| InChIKey | RAKJVIPCCGXHHS-UHFFFAOYSA-N |
| SMILES | C1(=O)OC2=C(C/C=C(/C)\C)C(O)=CC=C2C=C1 |
| LogP | 3.342 (est) |
| FDA UNII | 7X6RF2708X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
osthenol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FO137895 | Osthenol | 484-14-0 | 1mg | $171.88 | 2026-06-04 | Buy |
| ChemScene | CS-0022826 | Osthenol 99.15% | 484-14-0 | 1mg | $130 | 2026-06-04 | Buy |
| ChemScene | CS-0022826 | Osthenol 99.15% | 484-14-0 | 5mg | $260 | 2026-06-04 | Buy |
| ChemScene | CS-0022826 | Osthenol 99.15% | 484-14-0 | 10mg | $390 | 2026-06-04 | Buy |
| ApexBio Technology | BA8507 | Osthenol | 484-14-0 | 1mg | $108 | 2026-05-06 | Buy |
osthenol Chemical Properties, Uses, Production
Chemical Properties
Soluble in methanol, ethanol, DMSO and other organic solvents, derived from Rhizoma et Radix Notopterygii.
Uses
Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 μM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 μM and shows a high selectivity index for hMAO-A versus hMAO-B[1].
Definition
ChEBI: Osthenol is a hydroxycoumarin that is umbelliferone in which the hydrogen at position 8 has been replaced by a prenyl group. It has a role as a plant metabolite and an antifungal agent. It is functionally related to an umbelliferone.
Biological Activity
Ostenol (Ostenol), a preacylated coumarin isolated from the dried roots of Ostonia, is a reversible, selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) (Ki=0.26 μM) . Oshenol has a potential selective inhibitory effect on recombinant hMAO-A with IC50 of 0.74 μM, showing a high selectivity index for hMAO-A and hMAO-B.
IC 50
hMAO-A: 0.26 μM (Ki); hMAO-A: 0.74 μM (IC50)
References
[1] Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. DOI:10.1016/j.bmcl.2019.01.016
[2] Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003. DOI:10.19540/j.cnki.cjcmm.20170512.003
osthenol Preparation Products And Raw materials
osthenol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Shanghai Aspire Biological Technology Co., Ltd. | 021-61317773 | sales@aspirebio.com | China | 2880 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Yihe Biological Technology Co., Ltd. | 021-68882955 17721395025 | 2423903095@qq.com | China | 5000 | 58 |
| Shanghai Uteam Biotechnology Co., Ltd. | 021-36031160 13311776681 | 3338195766@QQ.com | China | 5091 | 55 |
