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| | osthenol Basic information |
| Product Name: | osthenol | | Synonyms: | 7-Hydroxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one;7-Hydroxy-8-isopentenyl-2H-1-benzopyran-2-one;NSC 625328;2H-1-Benzopyran-2-one, 7-hydroxy-8-(3-methyl-2-buten-1-yl)-;inhibit,selective,Monoamine Oxidase,MAO,depression,competitive,Osthenol,Inhibitor,coumarin,Ostenol;Osthenol, 10 mM in DMSO;7-Hydroxy-8-prenylcoumarin;7-Hydroxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one | | CAS: | 484-14-0 | | MF: | C14H14O3 | | MW: | 230.26 | | EINECS: | | | Product Categories: | | | Mol File: | 484-14-0.mol |  |
| | osthenol Chemical Properties |
| Melting point | 89-91 °C | | Boiling point | 422.8±45.0 °C(Predicted) | | density | 1.203±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 8.45±0.20(Predicted) | | color | White to yellow | | InChI | InChI=1S/C14H14O3/c1-9(2)3-6-11-12(15)7-4-10-5-8-13(16)17-14(10)11/h3-5,7-8,15H,6H2,1-2H3 | | InChIKey | RAKJVIPCCGXHHS-UHFFFAOYSA-N | | SMILES | C1(=O)OC2=C(C/C=C(/C)\C)C(O)=CC=C2C=C1 | | LogP | 3.342 (est) |
| | osthenol Usage And Synthesis |
| Chemical Properties | Soluble in methanol, ethanol, DMSO and other organic solvents, derived from Rhizoma et Radix Notopterygii. | | Uses | Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 μM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 μM and shows a high selectivity index for hMAO-A versus hMAO-B[1]. | | Definition | ChEBI: Osthenol is a hydroxycoumarin that is umbelliferone in which the hydrogen at position 8 has been replaced by a prenyl group. It has a role as a plant metabolite and an antifungal agent. It is functionally related to an umbelliferone. | | Biological Activity | Ostenol (Ostenol), a preacylated coumarin isolated from the dried roots of Ostonia, is a reversible, selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) (Ki=0.26 μM) . Oshenol has a potential selective inhibitory effect on recombinant hMAO-A with IC50 of 0.74 μM, showing a high selectivity index for hMAO-A and hMAO-B. | | IC 50 | hMAO-A: 0.26 μM (Ki); hMAO-A: 0.74 μM (IC50) | | References | [1] Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. DOI:10.1016/j.bmcl.2019.01.016
[2] Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003. DOI:10.19540/j.cnki.cjcmm.20170512.003 |
| | osthenol Preparation Products And Raw materials |
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