2,4-Difluoro-5-nitroaniline
- CAS No.
- 123344-02-5
- Chemical Name:
- 2,4-Difluoro-5-nitroaniline
- Synonyms
- 2,4-Difluoro-5-nitroaniline;Benzenamine, 2,4-difluoro-5-nitro-
- CBNumber:
- CB3131475
- Molecular Formula:
- C6H4F2N2O2
- Molecular Weight:
- 174.1
- MDL Number:
- MFCD04038395
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2921490090 |
2,4-Difluoro-5-nitroaniline price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC909005 | 2,4-Difluoro-5-nitroaniline 98% | 123344-02-5 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC909005 | 2,4-Difluoro-5-nitroaniline 98% | 123344-02-5 | 5g | $44 | 2026-06-04 | Buy |
| Apolloscientific | PC909005 | 2,4-Difluoro-5-nitroaniline 98% | 123344-02-5 | 25g | $209 | 2026-06-04 | Buy |
| Apolloscientific | PC909005 | 2,4-Difluoro-5-nitroaniline 98% | 123344-02-5 | 100g | $830 | 2026-06-04 | Buy |
| Apolloscientific | PC909005 | 2,4-Difluoro-5-nitroaniline 98% | 123344-02-5 | 500g | $3498 | 2026-06-04 | Buy |
2,4-Difluoro-5-nitroaniline Chemical Properties, Uses, Production
Uses
2,4-Difluoro-5-nitroaniline is intended for research use only and is not for human or veterinary use.
Synthesis
367-25-9
123344-02-5
Step 1: Synthesis of 2,4-difluoro-5-nitroaniline (71) At 0 °C, 2,4-difluoroaniline (0.394 mL, 3.87 mmol) was dissolved in concentrated sulfuric acid (5 mL, 94 mmol). Nitric acid (0.272 mL, 375 mg, 3.87 mmol) was added slowly and dropwise over 20 min. The reaction mixture was continued to be stirred at 5 °C for 30 min. Subsequently, the reaction mixture was poured into ice water and extracted with ether. The organic layer was washed with saturated NaHCO3 solution and after drying and evaporating the solvent, the target compound 2,4-difluoro-5-nitroaniline (71) was obtained (467 mg, 69.3% yield). NMR data (400 MHz, CDCl3): δ 3.91 (broad peak, 2H), 6.98 (triple peak, J = 10.2 Hz, 1H), 7.51 (double double peaks, J = 8.6 Hz and 7.0 Hz, 1H).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 19, p. 8027 - 8054
[2] Patent: CN107793413, 2018, A. Location in patent: Paragraph 0168-0171
[3] Patent: WO2011/147764, 2011, A1. Location in patent: Page/Page column 75-76
[4] Patent: US2013/79341, 2013, A1. Location in patent: Paragraph 0249
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 1, p. 241 - 253
2,4-Difluoro-5-nitroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Shanghai Na Qian Chemical Technology Co. Ltd. | 13598610367 13598610367 | 2841375912@qq.com | China | 3567 | 52 |
| Nanjing Duolong Bio-tech Co.,Ltd. | 18905173768 | 52513593@qq.com | China | 2337 | 50 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
