2,4-Difluoroaniline
- CAS No.
- 367-25-9
- Chemical Name:
- 2,4-Difluoroaniline
- Synonyms
- Difluoroaniline;4-Difluoroaniline;2,4-difluoro-anilin;Aniline, 2,4-difluoro-;2,4-DIFLUOROPHENYLAMINE;AKOS 91127;2,4-Difluoranilin;2,4-DIFLUROANILINE;2,4-DIFLOUROANILINE;2,4-Difluoroaniline
- CBNumber:
- CB7419359
- Molecular Formula:
- C6H5F2N
- Molecular Weight:
- 129.11
- MDL Number:
- MFCD00007648
- MOL File:
- 367-25-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -7.5 °C (lit.) |
|---|---|
| Boiling point | 170 °C/753 mmHg (lit.) |
| Density | 1.268 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 145 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Not miscible or difficult to mix. |
| form | Liquid |
| pka | 3.26±0.10(Predicted) |
| Specific Gravity | 1.284 (20/4℃) |
| color | Clear brown |
| Water Solubility | 1-5 g/100 mL at 20.55 ºC |
| Merck | 14,3147 |
| BRN | 2802556 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. |
| InChI | 1S/C6H5F2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2 |
| InChIKey | CEPCPXLLFXPZGW-UHFFFAOYSA-N |
| SMILES | Nc1ccc(F)cc1F |
| LogP | 1.7 at 25℃ and pH5-9 |
| CAS DataBase Reference | 367-25-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 40P93L7KWD |
| NIST Chemistry Reference | 2,4-Difluoroaniline(367-25-9) |
| EPA Substance Registry System | 2,4-Difluoroaniline (367-25-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352+P312-P361+P364 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 28-36/37/39-26-36 | |||||||||
| RIDADR | UN 2941 6.1/PG 3 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | BX3680000 | |||||||||
| F | 8-9-23 | |||||||||
| Hazard Note | Toxic | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214210 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 4 Oral |
|||||||||
| REACH Registrations | Inactive | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,4-Difluoroaniline price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D101400 | 2,4-Difluoroaniline 99% | 367-25-9 | 10g | $59.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | D101400 | 2,4-Difluoroaniline 99% | 367-25-9 | 25g | $89.9 | 2026-04-30 | Buy |
| TCI Chemical | D1508 | 2,4-Difluoroaniline >98.0%(GC)(T) | 367-25-9 | 25g | $58 | 2026-04-30 | Buy |
| TCI Chemical | D1508 | 2,4-Difluoroaniline >98.0%(GC)(T) | 367-25-9 | 500g | $686 | 2026-04-30 | Buy |
| Apolloscientific | PC2590 | 2,4-Difluoroaniline 97% | 367-25-9 | 100g | $25 | 2026-06-04 | Buy |
2,4-Difluoroaniline Chemical Properties, Uses, Production
Description
2,4-difluoroaniline is an important intermediate used in organic synthesis, pharmaceuticals agrochemicals, dyes, and agricultural chemicals.
Reference
R. Garth Pews, J. A. Gall, Process and intermediates for the preparation of 2,6-difluoroaniline, Paten US5041674A
Chemical Properties
dark red liquid
Uses
2,4-Difluoroaniline is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
General Description
Dark reddish-purple liquid.
Air & Water Reactions
2,4-Difluoroaniline may be sensitive to prolonged exposure to air. . Water soluble.
Reactivity Profile
Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
ACUTE/CHRONIC HAZARDS: 2,4-Difluoroaniline may be irritating to tissues.
Fire Hazard
2,4-Difluoroaniline is combustible.
Synthesis
446-35-5
367-25-9
The general procedure for the synthesis of 2,4-difluoroaniline from 2,4-difluoronitrobenzene was as follows: 2,4-difluoro-1-nitrobenzene (1 g), methanol (10 mL), and Pd/C catalyst (100 mg) were added to a 100 mL single-necked reaction flask. Subsequently, the reaction system was replaced three times with hydrogen to remove air. The reaction mixture was stirred at room temperature for 2-3 hours. Upon completion of the reaction, the catalyst was removed by filtration under reduced pressure and the filtrate was concentrated to give 810 mg of the target product 2,4-difluoroaniline.
References
[1] Synthetic Communications, 2012, vol. 42, # 2, p. 213 - 222
[2] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2011, vol. 41, # 1, p. 114 - 119
[3] Journal fuer Praktische Chemie (Leipzig), 1934, vol. <2> 140, p. 97,111
[4] Chemische Berichte, 1937, vol. 70, p. 2396,2400
2,4-Difluoroaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yancheng Green Fluorine Fine Chemical Trading Co., Ltd | 17887358129 | lvfu@163.cn | China | 40 | 58 |
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Weifang Siyuan Chemical Co., Ltd. | 0536-8888106 17663601818 | 2354379876@qq.com | China | 244 | 58 |
| Shandong Xibang Biological Technology Development Co. LTD | 0536-3611186 15063661551 | 196056703@qq.com | China | 58 | 58 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| xiamen hongyi | 18060930853 | 18060930853@163.com | China | 16 | 58 |
| Zhongsu Supply Chain Management (Shandong) Co.,Ltd. | 15726167122 | zsscm01@163.com | China | 294 | 58 |
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
View Latest Price from 2,4-Difluoroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2,4-Difluoroaniline
367-25-9
|
$9.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2,4-Difluoroaniline
367-25-9
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 2, 4-Difluoroaniline
367-25-9
|
$10.50 | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2,4-Difluoroaniline
367-25-9
- $9.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,4-Difluoroaniline
367-25-9
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2, 4-Difluoroaniline
367-25-9
- $10.50
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
