jadomycin B
- CAS No.
- 149633-99-8
- Chemical Name:
- jadomycin B
- Synonyms
- jadomycin B;Anthraquinone Impurity 13;8H-Benz[b]oxazolo[3,2-f]phenanthridine-2,8,13(1H,3aH)-trione, 12-[(2,6-dideoxy-α-L-ribo-hexopyranosyl)oxy]-7-hydroxy-5-methyl-1-[(1S)-1-methylpropyl]-
- CBNumber:
- CB31320403
- Molecular Formula:
- C30H31NO9
- Molecular Weight:
- 549.57
- MDL Number:
- MFCD00865143
- MOL File:
- 149633-99-8.mol
| Boiling point | 842.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 1mg/mL |
| pka | 7.83±0.40(Predicted) |
| form | powder |
| biological source | Streptomyces venezuelae |
| InChIKey | BSBSCJRAEMDCHC-UHFFFAOYSA-N |
| SMILES | N21C(OC(=O)C2C(CC)C)c3c(c(cc(c3)C)O)C4=C1C(=O)c5c(cccc5OC6OC(C(C(C6)O)O)C)C4=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
jadomycin B price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | ZFA63399 | Jadomycin B | 149633-99-8 | 0.01mg | $269.52 | 2026-06-05 | Buy |
| Biosynth | ZFA63399 | Jadomycin B | 149633-99-8 | 0.025mg | $499.12 | 2026-06-05 | Buy |
| Biosynth | ZFA63399 | Jadomycin B | 149633-99-8 | 0.05mg | $739.44 | 2026-06-05 | Buy |
| Biosynth | ZFA63399 | Jadomycin B | 149633-99-8 | 0.1mg | $1095.46 | 2026-06-05 | Buy |
| Biosynth | ZFA63399 | Jadomycin B | 149633-99-8 | 0.25mg | $2028.63 | 2026-06-05 | Buy |
jadomycin B Chemical Properties,Uses,Production
Uses
Jadomycin B, is produced by Streptomyces venezuelae fermentation. It is an angucycline antibiotic containing an unusual 8H-benz[b]oxazolo[3,2-f]-phenanthridine ring system and a rare carbohydrate, digitoxose.1,2
Jadomycin B displays antimicrobial, anti-tumor, aurora-B kinase inhibition, DNA cleaving and more activities.3,4,5,6
Jadomycin B was found to be active against a variety of staphylococci, including methicillin-resistant Staphylococcus aureus in a MIC of 1μg/ml.3 In addition, its anti-tumor activity was demonstrated as it kills drug-sensitive and multidrug-resistant breast cancer cell, through inhibition of type II topoisomerases and the induction of DNA damage and apoptosis. Jadomycin B (15 mM), 24-hour treatment significantly lowered the levels of topoisomerase IIa protein versus the vehicle control.4
It was also shown that Jadomycin B inhibits Aurora-B kinase activity by phosphorylation of histone H3 on Ser10 in a dose-dependent manner (10μg /mL Jadomycin B reduced H3 phosphorylation by 70%).5
Jadomycin B was also found to cleave DNA in the presence of Cu (II) by reducing it to Cu(I) which can further react with H2O2 to form hydroxyl radicals that causes DNA strand scission without the requirement of any external reducing agent. The EC50 value of Jadomycin B for single-strand scission was approximately 1.7μM.6
Biological Activity
Anti cancer, anti microbial
jadomycin B Preparation Products And Raw materials
Raw materials
Preparation Products
jadomycin B Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@yongstandards.com | China | 9995 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 | wendy@huidabiotech.com | CHINA | 87 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 | contact@trustwe.com | China | 5757 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Shanghai Yanchun Biopharmaceutical Technology Co., Ltd | 4001-009266 17349750668 | product@sci-e.com | China | 2808 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 81148925 17391631969 | 1023@dideu.com | China | 9999 | 58 |
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