zaluzanin C
- CAS No.
- 16838-87-2
- Chemical Name:
- zaluzanin C
- Synonyms
- zaluzanin C;(3aβ,6aβ,9aβ,9bα)-3,6,9-Trismethylene-8α-hydroxydodecahydroazuleno[4,5-b]furan-2-one;Azuleno[4,5-b]furan-2(3H)-one, decahydro-8-hydroxy-3,6,9-tris(methylene)-, (3aS,6aR,8S,9aR,9bS)-
- CBNumber:
- CB31343990
- Molecular Formula:
- C15H18O3
- Molecular Weight:
- 246.3
- MDL Number:
- MOL File:
- 16838-87-2.mol
zaluzanin C Chemical Properties,Uses,Production
Uses
Zaluzanin C is a sesquiterpene lactone. Zaluzanin C has anti-inflammatory activity and can inhibit the production of mtROS, block the NF-κB signaling pathway, and reduce the production of TNF-α. In addition, Zaluzanin C can inhibit the differentiation of 3T3-L1 preadipocytes into mature adipocytes[1][2][3].
Definition
ChEBI: A sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and a hydroxy group at position 8.
References
[1] Valkute TR, et al. Synthesis and anticancer studies of Michael adducts and Heck arylation products of sesquiterpene lactones, zaluzanin D and zaluzanin C from Vernonia arborea. RSC Adv. 2018 Nov 14;8(67):38289-38304. DOI:10.1039/c8ra06238b
[2] Kwak SH, et al. Zaluzanin C Inhibits Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes. J Obes Metab Syndr. 2019 Jun;28(2):105-111. DOI:10.7570/jomes.2019.28.2.105
[3] Jung JW, et al. Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS. Molecules. 2023 Nov 8;28(22):7484. DOI:10.3390/molecules28227484
