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| | zaluzanin C Basic information |
| Product Name: | zaluzanin C | | Synonyms: | zaluzanin C;(3aβ,6aβ,9aβ,9bα)-3,6,9-Trismethylene-8α-hydroxydodecahydroazuleno[4,5-b]furan-2-one;Azuleno[4,5-b]furan-2(3H)-one, decahydro-8-hydroxy-3,6,9-tris(methylene)-, (3aS,6aR,8S,9aR,9bS)- | | CAS: | 16838-87-2 | | MF: | C15H18O3 | | MW: | 246.3 | | EINECS: | | | Product Categories: | | | Mol File: | 16838-87-2.mol |  |
| | zaluzanin C Chemical Properties |
| Melting point | 95-96 °C | | Boiling point | 439.9±45.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | pka | 14.65±0.20(Predicted) |
| | zaluzanin C Usage And Synthesis |
| Uses | Zaluzanin C is a sesquiterpene lactone. Zaluzanin C has anti-inflammatory activity and can inhibit the production of mtROS, block the NF-κB signaling pathway, and reduce the production of TNF-α. In addition, Zaluzanin C can inhibit the differentiation of 3T3-L1 preadipocytes into mature adipocytes[1][2][3]. | | Definition | ChEBI: A sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and a hydroxy group at position 8. | | References | [1] Valkute TR, et al. Synthesis and anticancer studies of Michael adducts and Heck arylation products of sesquiterpene lactones, zaluzanin D and zaluzanin C from Vernonia arborea. RSC Adv. 2018 Nov 14;8(67):38289-38304. DOI:10.1039/c8ra06238b
[2] Kwak SH, et al. Zaluzanin C Inhibits Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes. J Obes Metab Syndr. 2019 Jun;28(2):105-111. DOI:10.7570/jomes.2019.28.2.105
[3] Jung JW, et al. Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS. Molecules. 2023 Nov 8;28(22):7484. DOI:10.3390/molecules28227484 |
| | zaluzanin C Preparation Products And Raw materials |
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