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ChemicalBook >> CAS DataBase List >>4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate Structure
4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate structure
CAS No.
114568-26-2
Chemical Name:
4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate
Synonyms
Patomostat;4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate;4-Guanidinobenzoic acid 4-[[2-(2,5-dioxopyrrolidin-1-yl)ethyl]thio]phenyl ester;Benzoic acid, 4-[(aminoiminomethyl)amino]-, 4-[[2-(2,5-dioxo-1-pyrrolidinyl)ethyl]thio]phenyl ester
CBNumber:
CB31373166
Molecular Formula:
C20H20N4O4S
Molecular Weight:
412.46
MDL Number:
MFCD00868441
MOL File:
114568-26-2.mol
MSDS File:
SDS
Last updated:2026-07-16 07:06:08
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4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate Properties

Melting point 201.6 °C
Boiling point 653.2±65.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. 4°C, away from moisture and light
pka 10.17±0.10(Predicted)
form Solid
color White to off-white
FDA UNII 2T7W4EA51W

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth PEA56826 Patamostat 114568-26-2 10mg $815 2026-06-04 Buy
Biosynth PEA56826 Patamostat 114568-26-2 25mg $1329 2026-06-04 Buy
Biosynth PEA56826 Patamostat 114568-26-2 50mg $2126.5 2026-06-04 Buy
ChemScene CS-0064977 Patamostat 98.13% 114568-26-2 5mg $325 2026-06-04 Buy
ChemScene CS-0064977 Patamostat 98.13% 114568-26-2 10mg $520 2026-06-04 Buy
Product number Packaging Price Buy
PEA56826 10mg $815 Buy
PEA56826 25mg $1329 Buy
PEA56826 50mg $2126.5 Buy
CS-0064977 5mg $325 Buy
CS-0064977 10mg $520 Buy

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate Chemical Properties, Uses, Production

Uses

Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2].

in vivo

Patamostat (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner[1].
Patamostat (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis[1].
Patamostat (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats[2].

Animal Model:Male Wistar rats weighing about 350 g[2]
Dosage:2 mg/kg
Administration:Continuous infusion per h for 1 h
Result:Significantly improved the survival rate.

References

[1] K Miyamoto, et al. [Effects of E-3123, a New Protease Inhibitor, on Several Protease Activities and on Experimental Acute Pancreatitis]. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93. DOI:10.1254/fpj.91.285
[2] T Hirano, et al. Protective Effect of a Cephalosporin, Shiomarin, Plus a New Potent Protease Inhibitor, E3123, on Rat Taurocholate-Induced Pancreatitis. J Gastroenterol Hepatol. Jan-Feb 1993;8(1):52-9. DOI:10.1111/j.1440-1746.1993.tb01175.x

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate Suppliers

Global Suppliers ( 7)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 4000862158 18117107507 vip@med-life.cn China 4999 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58

View Latest Price from 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Patamostat pictures 2026-07-15 Patamostat
114568-26-2
 $916.00-1860.00 10g TargetMol Chemicals Inc.
  • Patamostat pictures
  • Patamostat
    114568-26-2
  • $916.00-1860.00
  • TargetMol Chemicals Inc.

114568-26-2 (4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate) Related Search:

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4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate 4-Guanidinobenzoic acid 4-[[2-(2,5-dioxopyrrolidin-1-yl)ethyl]thio]phenyl ester Patomostat Benzoic acid, 4-[(aminoiminomethyl)amino]-, 4-[[2-(2,5-dioxo-1-pyrrolidinyl)ethyl]thio]phenyl ester 114568-26-2