AK 2123
- CAS No.
- 104958-90-9
- Chemical Name:
- AK 2123
- Synonyms
- Sanazole;AK 2123;N-(2-Methoxyethyl)-3-nitro-1H-1,2,4-triazole-1-acetamide
- CBNumber:
- CB31389545
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01027037
- MOL File:
- 104958-90-9.mol
- MSDS File:
- SDS
| FDA UNII | 1EIF6HTA24 |
|---|
AK 2123 Chemical Properties, Uses, Production
Uses
Sanazole (AK-2123) is a hypoxic cell radiosensitizer. Sanazole enhances radiation-induced DNA strand breaks. In mouse fibroblast tumors, Sanazole increases nuclear condensation and fragmentation, as well as elevates caspase-3 activity, thereby enhancing radiation-induced apoptosis. These characteristics make Sanazole a promising candidate for research in tumor therapy[1][2].
References
[1] Rajagopalan, et al. Radiosensitizer Sanazole (AK-2123) enhances γ-radiation-induced Apoptosis in murine fibrosarcoma. Journal of radiation research 44.4 (2003): 359-365. DOI:10.1269/jrr.44.359
[2] García-Angulo, et al. "Intratumoral and parametrial infusion of a 3-nitrotriazole (AK-2123) in the radiotherapy of the uterine cervix cancer: stage II–III—preliminary positive results." International Journal of Radiation Oncology Biology Physics 22.3 (1992): 589-591. DOI:10.1016/0360-3016(92)90883-j
AK 2123 Preparation Products And Raw materials
Raw materials
Preparation Products
AK 2123 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
