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3-Nitro-1,2,4-triazole

3-Nitro-1,2,4-triazole Structure
3-Nitro-1,2,4-triazole structure
CAS No.
24807-55-4
Chemical Name:
3-Nitro-1,2,4-triazole
Synonyms
3-NITRO-1H-1,2,4-TRIAZOLE;3-NTR;3-Nitro-1;NSC 133107;AKOS B006601;AKOS MSC-0736;3-nitrotriazole;3-Nitro-s-triazole;s-Triazole, 3-nitro-;3-Nitro-1,2,4-triazo
CBNumber:
CB7448098
Molecular Formula:
C2H2N4O2
Molecular Weight:
114.06
MDL Number:
MFCD00009749
MOL File:
24807-55-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:43:20
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3-Nitro-1,2,4-triazole Properties

Melting point 210 °C (dec.)(lit.)
Boiling point 213.51°C (rough estimate)
Density 1.7897 (rough estimate)
refractive index 1.4164 (estimate)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Methanol
form Solid
pka 5.92±0.20(Predicted)
color Light Yellow
Water Solubility slightly soluble
BRN 607167
InChI InChI=1S/C2H2N4O2/c7-6(8)2-3-1-4-5-2/h1H,(H,3,4,5)
InChIKey KUEFXPHXHHANKS-UHFFFAOYSA-N
SMILES N1C([N+]([O-])=O)=NC=N1
CAS DataBase Reference 24807-55-4(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference 1H-1,2,4-triazole, 3-nitro-(24807-55-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  22-24/25-36-26
WGK Germany  3
F  9
HazardClass  IRRITANT
HS Code  29339990
NFPA 704
1
0 0

3-Nitro-1,2,4-triazole price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical N0477 3-Nitro-1,2,4-triazole [Coupling Agent] >98.0%(HPLC)(T) 24807-55-4 1g $19 2026-04-30 Buy
TCI Chemical N0477 3-Nitro-1,2,4-triazole [Coupling Agent] >98.0%(HPLC)(T) 24807-55-4 5g $29 2026-04-30 Buy
Usbiological N2683 3-Nitro-1,2,4-triazole 5g $425 2026-06-03 Buy
Biosynth FN26242 3-Nitro-1,2,4-triazole 24807-55-4 0.5kg $687.5 2026-06-04 Buy
Biosynth FN26242 3-Nitro-1,2,4-triazole 24807-55-4 1kg $893.75 2026-06-04 Buy
Product number Packaging Price Buy
N0477 1g $19 Buy
N0477 5g $29 Buy
N2683 5g $425 Buy
FN26242 0.5kg $687.5 Buy
FN26242 1kg $893.75 Buy

3-Nitro-1,2,4-triazole Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Solid

Uses

3-Nitro-1,2,4-triazole is used in oligonucleotide synthesis. Also a radiosensitizer of hypoxic cells in vitro.

Synthesis

3-Amino-1,2,4-Triazole

61-82-5

3-Nitro-1,2,4-triazole

24807-55-4

General procedure for the synthesis of 3-nitro-1,2,4-triazole from 1H-1,2,4-triazol-5-amine: In a fume hood, 3-amino-1,2,4-triazole (26.3 g, 0.297 mol) was added to an aqueous solution of sodium nitrite (100.0 g, 1.45 mol, dissolved in 150 ml of water) fitted with an overhead mechanical stirrer and a 100 ml homogeneous pressure dosing funnel in a 2.0 liter three-necked round-bottomed flask. The suspension was cooled in an ice water bath and the mechanical stirrer was activated. After stirring for 10 minutes, concentrated nitric acid (85 ml) was slowly added dropwise through the dosing funnel for a controlled period of 2.5-3.0 hours (note the foaming phenomenon). After the dropwise addition was completed, the ice water bath was removed and the yellow suspension was continued to be stirred at room temperature for 1 hr until the foaming stopped. The crude product was collected by filtration and the yellow solid cake was dried overnight under vacuum with an oil pump to give 47 g of product. The crude product was dissolved in boiling methanol (300 ml) for 30 min, followed by room vacuum filtration. The filtrate was cooled to room temperature and placed in a refrigerator at -15°C overnight to crystallize 3-nitro-1,2,4-triazole as a light yellow solid. The crystallized product was washed with cold methanol and dried overnight at a pressure of 1.9 mmHg to give 21-23 g (62%-68% yield) of 3-nitro-1,2,4-triazole with a melting point of 208°C-211°C (literature values 208°C-210°C). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.86 (s, 1H); 13C NMR (75 MHz, DMSO-d6): δ 163.1,146.3; IR (solid): 3162,2861,2776,2730 cm-1. The purity of the product was determined to be 97% by RP-HPLC with retention time tR=2.01 min (detection wavelength 254 nm).

References

[1] Organic Process Research and Development, 2014, vol. 18, # 7, p. 886 - 890
[2] Tetrahedron, 1980, vol. 36, # 20-21, p. 3075 - 3085
[3] Organic Preparations and Procedures International, 2014, vol. 46, # 3, p. 267 - 271
[4] Russian Journal of Organic Chemistry, 2014, vol. 50, # 5, p. 742 - 746
[5] Zh. Org. Khim., 2014, vol. 50, # 5, p. 752 - 756,5

3-Nitro-1,2,4-triazole Preparation Products And Raw materials

Raw materials

3-Amino-1,2,4-Triazole Sulfuric acid Sodium nitrite Nitric acid

Preparation Products

2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate 3-Chloro-1,2,4-triazole 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole CHEMBRDG-BB 5355531

3-Nitro-1,2,4-triazole Suppliers

Global( 252)Suppliers
Supplier Tel Email Country ProdList Advantage
Zibo Guangyun Chemical Co., Ltd 18105338618 zbgyhx@126.com China 57 58
Henan yingchuang 16650708709 hnyingchuang@163.com China 3978 58
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 472 75
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Supplier Advantage
Zibo Guangyun Chemical Co., Ltd 58
Henan yingchuang 58
Suzhou Highfine Biotech Co., Ltd 75
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chembest Research Laboratories Limited 61
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56

View Lastest Price from 3-Nitro-1,2,4-triazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Nitro-1,2,4-triazole pictures 2026-08-25 3-Nitro-1,2,4-triazole
24807-55-4
 $70.00-700.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
3-Nitro-1,2,4-triazole pictures 2025-06-27 3-Nitro-1,2,4-triazole
24807-55-4
 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
3-Nitro-1,2,4-triazole pictures 2023-08-29 3-Nitro-1,2,4-triazole
24807-55-4
 $60.00 1kg 99% 1000tons Henan Bao Enluo International TradeCo.，LTD

3-Nitro-1,2,4-triazole Spectrum

3-Nitro-1,2,4-triazole(24807-55-4)1HNMR3-Nitro-1,2,4-triazole(24807-55-4)13CNMR3-Nitro-1,2,4-triazole(24807-55-4)IR13-Nitro-1,2,4-triazole(24807-55-4)IR2

24807-55-4(3-Nitro-1,2,4-triazole)Related Search:

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AKOS MSC-0736 AKOS B006601 3-NITRO-1,2,4-TRIAZOLE s-Triazole, 3-nitro- 1H-1,2,4-Triazole, 3-nitro- 1H-1,2,4-Triazole,3-nitro-(9CI) 5-NITRO-1H-[1,2,4]TRIAZOLE 3-nitro-1,2,4-triazolo 3-Nitro-1,2,4-triazole [Coupling Agent] 3-Nitro-2H-1,2,4-triazole 3-Nitro-s-triazole 3-Nitro-1,2,4-triazole ,99% 3-Nitro-1,2,4-triazole,96% 3-Nitro-1,2,4-triazole, 98+% 3-Nitro-1,2,4-triaChemicalbookzole 3-Nitro-1 3-NTR NSC 133107 3-NITRO-1H-1,2,4-TRIAZOLE FOR SYNTHESIS 3-Nitro-1,2,4-triazo 3-nitrotriazole 3-Nitro-1,2,4-triazole[CouplingAgent]> 1H-1,2,4-Triazole, 5-nitro- 3-Nitro-1H-1,2,4-triazoL 3-NITRO-1,2,4-TRIAZOLE 24807-55-4 3-nitro-H'-1,2,4-Triazole 3-NITRO-1H-1,2,4-TRIAZOLE 24807-55-4 C2H2N4O2 Building Blocks Triazoles Heterocyclic Building Blocks DNA / RNA Synthesis Condensing Agents (DNA / RNA Synthesis) Condensation & Active Esterification Heterocycles Nucleotides and Nucleosides NITRO FINE Chemical & INTERMEDIATES Building Blocks Heterocyclic Building Blocks Triazoles Biochemistry Condensation & Active Esterification Condensing Agents (DNA / RNA Synthesis) Nucleosides, Nucleotides & Related Reagents Protecting Agents, Phosphorylating Agents & Condensing Agents Synthetic Organic Chemistry Bases & Related Reagents Nucleotides