2-Benzoylamino-1,4-naphthoquinone
- CAS No.
- 65240-86-0
- Chemical Name:
- 2-Benzoylamino-1,4-naphthoquinone
- Synonyms
- PPM-18;NQN-1 (PPM-18);2-BenzaMido-1,4-naphthoquinone;2-Benzoylamino-1,4-naphthoquinone;N-(1,4-Dioxo-1,4-dihydronaphthalen-2-yl)benzamide;Benzamide, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-
- CBNumber:
- CB3142172
- Molecular Formula:
- C17H11NO3
- Molecular Weight:
- 277.27
- MDL Number:
- MFCD18427708
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
2-Benzoylamino-1,4-naphthoquinone price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13327 | PPM-18 ≥95% | 65240-86-0 | 1mg | $21 | 2026-04-30 | Buy |
| Cayman Chemical | 13327 | PPM-18 ≥95% | 65240-86-0 | 5mg | $86 | 2026-04-30 | Buy |
| Cayman Chemical | 13327 | PPM-18 ≥95% | 65240-86-0 | 10mg | $152 | 2026-04-30 | Buy |
| Cayman Chemical | 13327 | PPM-18 ≥95% | 65240-86-0 | 25mg | $329 | 2026-04-30 | Buy |
| TRC | TRC-B184990-25MG | 2-Benzamido-1,4-naphthoquinone | 65240-86-0 | 25mg | $294 | 2026-06-03 | Buy |
2-Benzoylamino-1,4-naphthoquinone Chemical Properties, Uses, Production
Uses
2-Benzamido-1,4-naphthoquinone belongs to a novel class of small molecule inhibitors of histone deacetylase (HDAC6), a family of enzymes that play significant role in numerous biological processes and diseases. 2-Benzamido-1,4-naphthoquinone was also shown to be an activation blocker of nuclear factor-kB (NF-kB).
Definition
ChEBI: PPM-18 is a naphthoquinone.
Biological Activity
ppm-18 is a chemically synthesized naphthoquinone derivative and an anti-inflammatory agent that inhibits the expression of inducible no synthase (inos). nos catalyzes the oxidation of the amino acid l-arginine to form no. as an important cellular signaling molecule, no has been implicated in modulating vascular tone, airway tone, insulinsecretion, and peristalsis. it has also been shown that no is involved in angiogenesis and neural development and can function as a retrograde neurotransmitter
in vitro
pretreatment of rat alveolar macrophages with ppm-18 (0.1-10 μm) significantly inhibited nitrite production, inos mrna accumulation and inos protein expression. ppm-18 did not affect the enzymic activities of inos and other constitutive nos forms directly. ppm-18 (10 μm) inhibited the lps-induced increase in nuclear transcription factor κb (nf-κb) p65 and p50 in nucleus.. ppm-18 significantly decreased lps-induced the production of tumour necrosis factor α [1]. ppm-18 inhibited nf-κb activation with an ic50 of 5 μm [3].
in vivo
in rats, intravenously pretreatment with ppm-18 (15 mg/kg) maintained a significantly higher mean arterial pressure compared with lps-treated controls. ppm-18 protected mice against lps-induced lethal toxicity. in mice, ppm-18 (5 or 15 mg/kg) dose-dependently decreased the lethality. in the mouse model of sepsis, ppm-18 exhibited as a potent inhibitor of inos expression by blocking the binding of nf-κb to promoter and exerted a beneficial effect [1].
References
[1] yu m s, lin j f w u t l, kuo c s. inhibition of nitric oxide synthase expression by ppm-18, a novel anti-inflammatory agent, in vitro and in vivo[j]. biochemical journal, 1997, 328(2): 363-369.
[2] beck k f, eberhardt w, frank s, et al. inducible no synthase: role in cellular signalling[j]. journal of experimental biology, 1999, 202(6): 645-653.
[3] davis, m. e.,grumbach, i.m.,fukai, t., et al. shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor κb binding.the journal of biological chemisty 279(1), 163-168 (2004).
2-Benzoylamino-1,4-naphthoquinone Preparation Products And Raw materials
Raw materials
Preparation Products
2-Benzoylamino-1,4-naphthoquinone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2968 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Jurong Coupling Biotechnology Co., Ltd. | 13656108824 | coupling278191416@hotmail.com | CHINA | 184 | 58 |
