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PqsR-IN-3

PqsR-IN-3 Structure
PqsR-IN-3 structure
CAS No.
3033007-79-0
Chemical Name:
PqsR-IN-3
Synonyms
PqsR-IN-3;4(1H)-Pyridinone, 3-hydroxy-1,6-dimethyl-2-[[[[1-(4-phenoxyphenyl)-1H-1,2,3-triazol-4-yl]methyl]amino]methyl]-
CBNumber:
CB314286273
Molecular Formula:
C23H23N5O3
Molecular Weight:
417.46
MDL Number:
MOL File:
3033007-79-0.mol
Last updated:2025-04-18 09:52:03
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PqsR-IN-3 Properties

Boiling point 603.1±65.0 °C(predicted)
Density 1.29±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka 9.73±0.40(predicted)

PqsR-IN-3 Chemical Properties, Uses, Production

Uses

PqsR-IN-3 (compound 16e) is a selective inhibitor of the pqs system (IC50=3.7 μM) and its associated virulence factor pyocyanin (IC50=2.7 μM). PqsR-IN-3 inhibits bacterial biofilm synthesis and is significantly cytotoxic against Pseudomonas aeruginosa. PqsR-IN-3 has synergistic effects with several antibiotics, such as Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441)[1].

References

[1] Miao ZY et al. 3-Hydroxypyridin-4(1H)-one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa. J Med Chem. 2023 Nov 18. DOI:10.1021/acs.jmedchem.3c01328

PqsR-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

PqsR-IN-3 Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
TargetMol 58

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PqsR-IN-3 4(1H)-Pyridinone, 3-hydroxy-1,6-dimethyl-2-[[[[1-(4-phenoxyphenyl)-1H-1,2,3-triazol-4-yl]methyl]amino]methyl]- 3033007-79-0