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RyR2 stabilizer-1

RyR2 stabilizer-1 structure

CAS No.: 3012675-16-7

Chemical Name:: RyR2 stabilizer-1

Synonyms: RyR2 stabilizer-1

CBNumber:: CB314289683

Molecular Formula:: C28H46N2O3S

Molecular Weight:: 490.74

MDL Number:

MOL File:: 3012675-16-7.mol

Last updated:2025-04-18 09:52:04

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RyR2 stabilizer-1 Properties

Boiling point	629.3±55.0 °C(predicted)
Density	1.147±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	15.00±0.20(predicted)

RyR2 stabilizer-1 Chemical Properties, Uses, Production

Uses

RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias[1].

References

[1] Gyuzel Y. Mitronova, et al. 1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2aStimulating Activities. Journal of Medicinal Chemistry. 2023， Article ASAP. DOI:10.1021/acs.jmedchem.3c01235

RyR2 stabilizer-1 Preparation Products And Raw materials

Raw materials

Preparation Products

RyR2 stabilizer-1 Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol	400-821-0310 15002144251	xuexiang.shao@tsbiochem.com	China	29128	58

Supplier	Advantage
TargetMol	58

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RyR2 stabilizer-1 3012675-16-7