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ALPHA-AMANITIN

ALPHA-AMANITIN structure

CAS No.: 23109-05-9

Chemical Name:: ALPHA-AMANITIN

Synonyms: α-Amanitin;A-AMANITIN;Aids004473;α-Amatoxin;Aids-004473;AMANITIN, A-;ALPHA-AMANTIN;ALPHA-AMANITIN;alpha-amatoxin;ALPHA-AMANTINE

CBNumber:: CB3142945

Molecular Formula:: C39H54N10O14S

Molecular Weight:: 918.98

MDL Number:: MFCD30207890

MOL File:: 23109-05-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:57:59

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ALPHA-AMANITIN Properties

Melting point	254-255 °C(lit.)
alpha	D20 +191°
Boiling point	1622.2±65.0 °C(Predicted)
Density	1.1626 (rough estimate)
refractive index	1.7400 (estimate)
storage temp.	−20°C
solubility	H₂O: 1.0 mg/mL
form	powder
pka	9.63±0.70(Predicted)
color	white to light yellow
biological source	Amanita phalloides
optical activity	+19120 (H2O)
Water Solubility	Soluble to 5 mM in ethanol and to 5 mM in water
ε(extinction coefficient)	13,500 at 310nm in H2O at 1M
Merck	13,370
BRN	1071138
InChIKey	CIORWBWIBBPXCG-PWKRRBCNNA-N
SMILES	CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(N)=O)C(=O)N5CC(O)CC5C(=O)NC(C(C)C(O)CO)C(=O)N2
EWG's Food Scores	1
FDA UNII	E04K0QZ999
UNSPSC Code	12352202
NACRES	NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H300-H373

Precautionary statements

P260-P264-P270-P301+P310-P314-P405

target organs

Kidney,Blood,Liver,Gastrointestinal tract,Respiratory Tract,Central nervous system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

T+

Risk Statements

26/27/28-33-26/28

Safety Statements

36/37/39-45-36/37-28

RIDADR

UN 3462 6.1/PG 2

WGK Germany

RTECS

BD6195000

8-10-18-21

HazardClass

6.1(a)

PackingGroup

HS Code

2934999090

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 1 Oral
STOT RE 2

Hazardous Substances Data

23109-05-9(Hazardous Substances Data)

Toxicity

LD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland)

NFPA 704

	0
4		0

ALPHA-AMANITIN price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A2263	α-Amanitin from Amanita phalloides, ≥90% (HPLC), powder	23109-05-9	1mg	$375	2026-04-30	Buy
Cayman Chemical	17898	α-Amanitin ≥90%	23109-05-9	1mg	$274	2026-04-30	Buy
Usbiological	257178	α-Amanitin ≥90%	23109-05-9	1mg	$446	2026-06-03	Buy
Biosynth	FA57619	α-Amanitin	23109-05-9	1mg	$628.23	2026-06-04	Buy
Biosynth	FA57619	α-Amanitin	23109-05-9	5mg	$1727.65	2026-06-04	Buy

Product number	Packaging	Price	Buy
A2263	1mg	$375	Buy
17898	1mg	$274	Buy
257178	1mg	$446	Buy
FA57619	1mg	$628.23	Buy
FA57619	5mg	$1727.65	Buy

ALPHA-AMANITIN Chemical Properties, Uses, Production

Uses

α-Amanitin has been used:

for inducing transcriptional arrest in NT2 cells prior to immunofluorescence assay
to induce nephrotoxicity in mice renal tissues
to induce and analyse genotoxicity in mice bone marrow cells by cell viability assay, comet assay and chromosomal aberration assay

Biological Activity

α-amanitin, the most deleterious toxin of a. phalloides to humans, inhibits rna polymerase ii (rnapii), causing hepatic and renal failure.

Biochem/physiol Actions

The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.

in vivo

The intravenous LD₅₀ dose of alpha-Amanitin is 0.327 mg/kg body weight after intravenous injection into BALB/c mice. After 12 h of alpha-Amanitin injection in caudal vein, the levels of WBC, RBC and HGB decrease significantly, while those of BUN and Crea increase significantly in serum. alpha-Amanitin inhibits some genes (Hsp90b1, Irx4, etc.), whose encoded proteins regulate the RNA polymerase II activity. alpha-Amanitin down-regulates some proteins (Nmi, Trpc5, etc.) taking part in the transcription progress^[1]. alpha-Amanitin has potent activity in DTC suppression. Mice injected with alpha-Amanitin (0.4 mg/kg, i.p.)-treated cells maintain their body weight, while those receiving a peritoneal injection of MKN45 cells show a constant decrease in body weight^[2].

IC 50

Traditional Cytotoxic Agents

storage

Store at -20°C

ALPHA-AMANITIN Preparation Products And Raw materials

Raw materials

Preparation Products

ALPHA-AMANITIN Suppliers

Global Suppliers ( 120)

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang Huida Biotech Co., Ltd.	0571-89903022 18679456698	zilong@hizyme.com	China	7853	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Nanjing Sunlida Biological Technology Co., Ltd.	025-57798810 18652991625	sales@sunlidabio.com	China	3223	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
Quality Control Solutions Ltd.	0755-66853366 13670046396	orders@qcsrm.com	China	18188	56

Supplier	Advantage
Zhejiang Huida Biotech Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Beijing HuaMeiHuLiBiological Chemical	58
Shanghai T&W Pharmaceutical Co., Ltd.	58
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
Nanjing Sunlida Biological Technology Co., Ltd.	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Quality Control Solutions Ltd.	56

View Latest Price from ALPHA-AMANITIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	ALPHA-AMANITIN 23109-05-9			0.99		RongNa Biotechnology Co.,Ltd
2024-04-17	alpha-Amanitin 23109-05-9	$9.00-70.00	10g	99%	10 tons	Hebei Kangcang new material Technology Co., LTD
2024-01-08	α-Amanitin 23109-05-9	$45.00-60.00	1mg	99.96%	1kg	Wuhan Boyuan Import & Export Co., LTD

ALPHA-AMANITIN
23109-05-9
0.99
RongNa Biotechnology Co.,Ltd

alpha-Amanitin
23109-05-9
$9.00-70.00
99%
Hebei Kangcang new material Technology Co., LTD

α-Amanitin
23109-05-9
$45.00-60.00
99.96%
Wuhan Boyuan Import & Export Co., LTD

23109-05-9 (ALPHA-AMANITIN) Related Search:

gamma-amanitin Methyl alpha-amanitin oleate ALPHA-AMANITIN OLEATE alpha-Amanitin, 1-l-aspartic acid- 6'-O-methyl alpha-amanitin

4,9-dioxo-5,10-diazatetradecane ALPHA-AMANITIN

1of2

Aids004473 Aids-004473 AMANITIN, a-(RG) AMANITIN, a-(RG)(CALL) cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide alpha-AMantine, froM AManita Phalloides AMANITIN, A- ALPHA-AMANITIN ALPHA-AMANITIN, AMANITA SPECIES ALPHA-AMANITINE Cyclo[L-Asn-L-t4Hyp-[(3R,4R)-4,5-dihydroxy-3-methyl-L-Nva-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-] alpha-amatoxin cyclic(l-asparaginyl-4-hydroxy-l-prolyl-(r)-4,5-dihydroxy-l-isoleucyl-6-hydrox ulfide,(r)-s-oxide y-2-mercapto-l-tryptophylglycyl-l-isoleucylglycyl-l-cysteinyl),cyclic(4-8)-s ALPHA-AMANITIN FROM AMANITA PHALLOIDES A-AMANITIN FROM AMANITA PHALLOIDES ALPHA-AMANTIN ALPHA-AMANTINE A-AMANTINE, FROM AMANITA PHALLOIDES alpha-Amanitine, from Amanita Phalloides Α-AMANITIN;Α-AMATOXIN alpha-Amanitin (α-Amanitin α-Amanitin DISCONTINUED α-Amanitin, from Amanita Phalloides α-Amatoxin *Chlorobutanol Impurity?1 (Chlorobutanol EP Impurity?A)(Chloroform) α-Amanitin A-AMANITIN 23109-05-9 C39H54N10O14S BioChemical Biochemicals and Reagents Cell Biology Cell Signaling and Neuroscience Gene Regulation and Expression Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Type Enzyme Inhibitors DNA-RNA Transcription Regulators Other Alkaloids DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience Gene Regulation and Expression Cell Signaling and Neuroscience Mushroom Toxins and Venoms Enzyme Inhibitors Enzyme Inhibitors by Type Other Miscellaneous Enzyme inhibitor