2-Amino-(4'-nitro)acetophenone hydrochloride
- CAS No.
- 5425-81-0
- Chemical Name:
- 2-Amino-(4'-nitro)acetophenone hydrochloride
- Synonyms
- AURORA 23208;OTAVA-BB BB7110952478;2-AMino-4'-nitroacetophenone HCl;2-AMino-p-nitro-acetophenone HCl;2-AMINO-P-NITRO-ACETOPHENONE HYDROCHLORIDE;2-Amino-(4'-nitro)acetophenone hydrochloride;2-AMINO-1-(4-NITRO-PHENYL)-ETHANONE HYDROCHLORIDE;2-Amino-1-(4-nitrophenyl)ethanone hydrochloride (1:1);Ethanone, 2-amino-1-(4-nitrophenyl)-, hydrochloride (1:1);2-Amino-(4′-nitro)acetophenone hydrochloride, CAS 5425-81-0
- CBNumber:
- CB3146488
- Molecular Formula:
- C8H9ClN2O3
- Molecular Weight:
- 216.62
- MDL Number:
- MFCD00025591
- MOL File:
- 5425-81-0.mol
- MSDS File:
- SDS
| Melting point | >211°C (dec) |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | 1S/C8H8N2O3.ClH/c9-5-8(11)6-1-3-7(4-2-6)10(12)13;/h1-4H,5,9H2;1H |
| SMILES | O=C(CN)C1=CC=C([N+]([O-])=O)C=C1.Cl |
| CAS DataBase Reference | 5425-81-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H314;H318 |
| Precautionary statements | P280;P301+P330+P331;P305+P351+P338;P310 |
2-Amino-(4'-nitro)acetophenone hydrochloride price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PH011994 | 2-amino-1-(4-nitrophenyl)ethanone hydrochloride AldrichCPR | 5425-81-0 | 100mg | $134 | 2023-06-20 | Buy |
| TRC | TRC-A578998-50MG | 2-Amino-1-(4-nitrophenyl)ethanone Hydrochloride | 5425-81-0 | 50mg | $72 | 2026-06-03 | Buy |
| TRC | TRC-A578998-500MG | 2-Amino-1-(4-nitrophenyl)ethanone Hydrochloride | 5425-81-0 | 500mg | $332 | 2026-06-03 | Buy |
| TRC | TRC-A578998-100MG | 2-Amino-1-(4-nitrophenyl)ethanone Hydrochloride | 5425-81-0 | 100mg | $105 | 2026-06-03 | Buy |
| AstaTech | A56080 | 2-AMINO-P-NITRO-ACETOPHENONE HCL 95% | 5425-81-0 | 1G | $49 | 2026-04-30 | Buy |
2-Amino-(4'-nitro)acetophenone hydrochloride Chemical Properties, Uses, Production
Synthesis
99-81-0
5425-81-0
Example 2: Synthesis of 2-amino-1-(4-nitrophenyl)ethanone hydrochloride 2-Bromo-4'-nitroacetophenone (25 g) prepared in Example 1 was dissolved in dichloromethane (250 mL), hexamethylenetetramine (20.1 g) was added, and the reaction was stirred for 1 hour at room temperature. After the reaction was completed, the solid crude product (30 g) was collected by filtration. The crude product was dissolved in a mixture of ethanol (162 mL) and concentrated hydrochloric acid (40 mL) and the reaction was continued with stirring for about 3 hours. After the reaction mixture was left to stand for about 48 hours, the solid product was precipitated, filtered, washed with water and dried to give the target compound 2-amino-1-(4-nitrophenyl)ethanone hydrochloride (refer to the method described in US4812470). Yield: 11.8 g (72% yield); 1H NMR (DMSO-d6, 300MHz): δ 8.3 (broad peak, 3H), 8.38 (double peak, 2H), 8.27 (double peak, 2H), 4.68 (single peak, 2H).
References
[1] Patent: WO2011/55289, 2011, A2. Location in patent: Page/Page column 36
[2] Patent: WO2012/29032, 2012, A2. Location in patent: Example 2
[3] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 324 - 342
[4] European Journal of Medicinal Chemistry, 2014, vol. 79, p. 203 - 215
[5] Journal of Medicinal Chemistry, 1982, vol. 25, # 9, p. 1045 - 1050
2-Amino-(4'-nitro)acetophenone hydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-Amino-(4'-nitro)acetophenone hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Suzhou Laing Biological Technology Co., LTD | 0512-62968256 18550502935 | export@laingbiotec.com | China | 993 | 58 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3968 | 60 |
View Latest Price from 2-Amino-(4'-nitro)acetophenone hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2-amino-(4'-nitro)acetophenone hydrochloride
5425-81-0
|
$1.10-9.90 | 1KG | 99% min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- 2-amino-(4'-nitro)acetophenone hydrochloride
5425-81-0
- $1.10-9.90
- 99% min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
