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2-Bromo-4'-nitroacetophenone

2-Bromo-4'-nitroacetophenone structure

CAS No.: 99-81-0

Chemical Name:: 2-Bromo-4'-nitroacetophenone

Synonyms: 2-BROMO-1-(4-NITROPHENYL)ETHAN-1-ONE;2-BROMO-1-(4-NITROPHENYL)ETHANONE;P-NITROPHENACYL BROMIDE;-bromo-4’ASISCHEM D48949;1,3-Bis(2’AKOS BBS-00003952;4-Nitrophecyl bromide;-cyano-phenoxy)propane;4-NITROPHENACYL BROMIDE

CBNumber:: CB4426103

Molecular Formula:: C8H6BrNO3

Molecular Weight:: 244.04

MDL Number:: MFCD00007356

MOL File:: 99-81-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-19 07:28:27

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2-Bromo-4'-nitroacetophenone Properties

Melting point	94-99 °C(lit.)
Boiling point	325.2±17.0 °C(Predicted)
Density	1.8033 (rough estimate)
refractive index	1.6090 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Crystalline Powder
color	Yellow to orange
BRN	393567
InChI	InChI=1S/C8H6BrNO3/c9-5-8(11)6-1-3-7(4-2-6)10(12)13/h1-4H,5H2
InChIKey	MBUPVGIGAMCMBT-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=C([N+]([O-])=O)C=C1)CBr
CAS DataBase Reference	99-81-0(CAS DataBase Reference)
FDA UNII	8NDY44R4NW
NIST Chemistry Reference	p-Nitrophenacyl bromide(99-81-0)
EPA Substance Registry System	2-Bromo-4'-nitroacetophenone (99-81-0)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

C,Xi

Risk Statements

34-37

Safety Statements

26-36/37/39-45

RIDADR

UN 3261 8/PG 2

WGK Germany

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29147000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

Limited Quantities

1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	1
3		0

2-Bromo-4'-nitroacetophenone price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	245615	2-Bromo-4′-nitroacetophenone 95%	99-81-0	10g	$89.9	2026-04-30	Buy
Sigma-Aldrich	245615	2-Bromo-4′-nitroacetophenone 95%	99-81-0	50g	$204	2026-04-30	Buy
TCI Chemical	N0473	2-Bromo-4'-nitroacetophenone >98.0%(GC)	99-81-0	5g	$17	2026-04-30	Buy
TCI Chemical	N0473	2-Bromo-4'-nitroacetophenone >98.0%(GC)	99-81-0	25g	$29	2026-04-30	Buy
Usbiological	263697	2-Bromo-4'-nitroacetophenone Asreported	99-81-0	25g	$333	2026-06-03	Buy

Product number	Packaging	Price	Buy
245615	10g	$89.9	Buy
245615	50g	$204	Buy
N0473	5g	$17	Buy
N0473	25g	$29	Buy
263697	25g	$333	Buy

2-Bromo-4'-nitroacetophenone Chemical Properties, Uses, Production

Chemical Properties

yellow to orange crystalline powder

Uses

2-Bromo-4′-nitroacetophenone was used to study the pKa of the histidine-34 imidazole.

Synthesis Reference(s)

Synthesis, p. 487, 1980 DOI: 10.1055/s-1980-29067

Synthesis

940-13-6

99-81-0

The general procedure for the synthesis of 2-bromo-4'-nitroacetophenone using the compound (CAS: 940-13-6) as starting material: haloalkynes (0.5 mmol), AgF (5 mol%), and water (1 eq.) were dissolved in trifluoroacetic acid (TFA, 1 mL), and the reaction was stirred for 6 hr at 40 °C. Upon completion of the reaction, TFA was recovered by distillation for reuse. The residue was purified by column chromatographic separation to afford the target product 2-bromo-4'-nitroacetophenone in pure form.

Purification Methods

Crystallise it from *C6H6/pet ether. [Beilstein 7 IV 661.]

References

[1] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375
[2] Chinese Journal of Chemistry, 2016, vol. 34, # 12, p. 1251 - 1254
[3] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986

2-Bromo-4'-nitroacetophenone Preparation Products And Raw materials

Raw materials

Methanol Benzene, 1-(bromoethynyl)-4-nitro- NISTC4203310 4-Nitroacetophenone 2-broMo-1-(4-nitrophenyl)ethanol

Preparation Products

FGH-10019 1H-Pyrrole-3-carboxylic acid, 2-aMino-5-(4-nitrophenyl)-, ethyl ester 2-(Chloromethyl)-4-(4-nitrophenyl)-1,3-thiazole 4-imidazo[2,1-b][1,3]thiazol-6-ylaniline

2-Bromo-4'-nitroacetophenone Suppliers

Global Suppliers ( 261)

Supplier	Tel	Email	Country	ProdList	Advantage
XUZHOU RUISAI BIOCHEMICAL TECHNOLOGY CO.,LTD.	--	2246953955@qq.com	China	12	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60

Supplier	Advantage
XUZHOU RUISAI BIOCHEMICAL TECHNOLOGY CO.,LTD.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
future industrial shanghai co., ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60

View Latest Price from 2-Bromo-4'-nitroacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	2-Bromo-4'-nitroacetophenone 99-81-0	$1.00-100.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	2-Bromo-4'-nitroacetophenone 99-81-0		1KG	99%	1000kgs	Shaanxi Dideu New Materials Co. Ltd
2020-02-26	2-Bromo-4'-nitroacetophenone 99-81-0		1KG	99.0%+	100 tons	Shaanxi Dideu Medichem Co. Ltd

2-Bromo-4'-nitroacetophenone
99-81-0
$1.00-100.00
99%
Henan Fengda Chemical Co., Ltd

2-Bromo-4'-nitroacetophenone
99-81-0
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

2-Bromo-4'-nitroacetophenone
99-81-0
99.0%+
Shaanxi Dideu Medichem Co. Ltd

2-Bromo-4'-nitroacetophenone Spectrum

2-Bromo-4'-nitroacetophenone(99-81-0)MS 2-Bromo-4'-nitroacetophenone(99-81-0)¹HNMR 2-Bromo-4'-nitroacetophenone(99-81-0)¹³CNMR 2-Bromo-4'-nitroacetophenone(99-81-0)IR1 2-Bromo-4'-nitroacetophenone(99-81-0)IR2

99-81-0 (2-Bromo-4'-nitroacetophenone) Related Search:

Acetophenone 2',4'-Dichloroacetophenone Bromonitromethane PIPERACETAZINE (250 MG) Sodium bromate

4'-Bromoacetophenone Ethidium bromide Clidinium bromide 2-Nitroacetophenone 2-Bromoacetophenone

p-Nitrophenylacetonitrile 4-Nitroacetophenone 3-Nitroacetophenone 3-Bromoanisole 2-Bromo-4'-methoxyacetophenone

4-Chloro-2'-bromoacetophenone Acetophenone-d8 2-Bromo-4'-chloroacetophenone

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ASISCHEM D48949 4'-NITROPHENACYL BROMIDE 4-NITROPHENACYL BROMIDE AKOS BBS-00003952 ALPHA-BROMO-P-NITROACETOPHENONE ALPHA-BROMO-4-NITROACETOPHENONE A-BROMO-P-NITROACETOPHENONE 2-BROMO-4'-NITROACENTOPHENONE 2-BroMo-4'-nitroacetonphenone 2-Bromo-1-(4-nitrophenyl)ethan-1-one, 2-Bromo-4'-nitroacetophenone 2-BroMo-4'-nitroacetophenone 95% α- broMo Nitroacetophenone 4-Nitrophecyl bromide 2-Bromo-p-nitroacetophenone 4'-Nitro-2-bromoacetophenone Acetophenone, 2-bromo-4'-nitro- Acetophenone, 2'-bromo-p-nitro- Ethanone, 2-bromo-1-(4-nitrophenyl)- omega-Bromo-p-nitroacetophenone p-Nitro-alpha-bromoacetophenone OMEGA-BROMO-4-NITROACETOPHENONE P-NITROPHENACYL BROMIDE 2-Bromo-4'-Nitroacetophenone 4'-Nitrophenacyl Bromide 2-Bromo-1-(4-Nitrophenyl)ethan-1-one A-BROMO-4-NITROACETOPHENONE à-bromo-4-nitroacetophenone ω-bromo-4-nitroacetophenone -bromo-4&rsquo ω-Bromo-4-nitroacetophenone, 4-Nitrophenacyl bromide 2-Bromo-4'-nitroacetophenone ,98% 4'-Nitro-ω-bromoacetophenone 2-Bromo-4'-nitroacetophenone,95% 2-Bromo-4′-nitroacetophenone,ω-Bromo-4-nitroacetophenone, 4-Nitrophenacyl bromide 2-Bromo-1-(4-nitrophenyl)ethan-1-one, TECH -methoxyacetophenone, 97.0 +% 1,3-Bis(2&rsquo -cyano-phenoxy)propane 4-Nitrophenacyl bromide 98% -(imidazol-1-yl)acetophenone 2-Bromo-4'-nitroacetophenone> 2-Bromo-4'-nitroacetophenone, 98%, for synthesis α-Bromo-4-nitroacetophenone 2-Bromo-4'-nitroacetophenone ISO 9001：2015 REACH 2-Bromo-4'-nitroacetophenone 2-Bromo-4′-nitroacetophenone, CAS 99-81-0 2-Bromo-4'-nitroacetophenone 2-BROMO-1-(4-NITROPHENYL)ETHANONE 2-BROMO-1-(4-NITROPHENYL)ETHAN-1-ONE 99-81-0 C8H6BrNO3 O2NC6H4COCH2Br Ketones Organic Building Blocks KETONE Building Blocks C7 to C8 Carbonyl Compounds B Bioactive Small Molecules