ChemicalBook >> CAS DataBase List >>2-Bromo-4'-nitroacetophenone
2-Bromo-4'-nitroacetophenone
- CAS No.
- 99-81-0
- Chemical Name:
- 2-Bromo-4'-nitroacetophenone
- Synonyms
- 2-BROMO-1-(4-NITROPHENYL)ETHAN-1-ONE;2-BROMO-1-(4-NITROPHENYL)ETHANONE;P-NITROPHENACYL BROMIDE;-bromo-4’ASISCHEM D48949;1,3-Bis(2’AKOS BBS-00003952;4-Nitrophecyl bromide;-cyano-phenoxy)propane;4-NITROPHENACYL BROMIDE
- CBNumber:
- CB4426103
- Molecular Formula:
- C8H6BrNO3
- Molecular Weight:
- 244.04
- MDL Number:
- MFCD00007356
- MOL File:
- 99-81-0.mol
- MSDS File:
- SDS
Last updated:2025-09-25 17:15:13
| Product description | Number | Pack Size | Price |
| 2-Bromo-4′-nitroacetophenone 95% | 245615 | 10g | $84.4 |
| 2-Bromo-4′-nitroacetophenone 95% | 245615 | 50g | $133.7 |
| 2-Bromo-4'-nitroacetophenone >98.0%(GC) | N0473 | 5g | $16 |
| 2-Bromo-4'-nitroacetophenone >98.0%(GC) | N0473 | 25g | $32 |
| 2-Bromo-4'-nitroacetophenone >98.0%(GC) | N0473 | 100g | $116 |
| More product size | |||
| Melting point | 94-99 °C(lit.) |
|---|---|
| Boiling point | 325.2±17.0 °C(Predicted) |
| Density | 1.8033 (rough estimate) |
| refractive index | 1.6090 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Crystalline Powder |
| color | Yellow to orange |
| BRN | 393567 |
| InChI | InChI=1S/C8H6BrNO3/c9-5-8(11)6-1-3-7(4-2-6)10(12)13/h1-4H,5H2 |
| InChIKey | MBUPVGIGAMCMBT-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=C([N+]([O-])=O)C=C1)CBr |
| CAS DataBase Reference | 99-81-0(CAS DataBase Reference) |
| FDA UNII | 8NDY44R4NW |
| NIST Chemistry Reference | p-Nitrophenacyl bromide(99-81-0) |
| EPA Substance Registry System | 2-Bromo-4'-nitroacetophenone (99-81-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 34-37 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29147000 | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
2-Bromo-4'-nitroacetophenone price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 245615 | 2-Bromo-4′-nitroacetophenone 95% | 99-81-0 | 10g | $84.4 | 2025-07-31 | Buy |
| Sigma-Aldrich | 245615 | 2-Bromo-4′-nitroacetophenone 95% | 99-81-0 | 50g | $133.7 | 2025-07-31 | Buy |
| TCI Chemical | N0473 | 2-Bromo-4'-nitroacetophenone >98.0%(GC) | 99-81-0 | 5g | $16 | 2025-07-31 | Buy |
| TCI Chemical | N0473 | 2-Bromo-4'-nitroacetophenone >98.0%(GC) | 99-81-0 | 25g | $32 | 2025-07-31 | Buy |
| TCI Chemical | N0473 | 2-Bromo-4'-nitroacetophenone >98.0%(GC) | 99-81-0 | 100g | $116 | 2025-07-31 | Buy |
2-Bromo-4'-nitroacetophenone Chemical Properties,Uses,Production
Chemical Properties
yellow to orange crystalline powder
Uses
2-Bromo-4′-nitroacetophenone was used to study the pKa of the histidine-34 imidazole.
Synthesis Reference(s)
Synthesis, p. 487, 1980 DOI: 10.1055/s-1980-29067
Synthesis
940-13-6
99-81-0
The general procedure for the synthesis of 2-bromo-4'-nitroacetophenone using the compound (CAS: 940-13-6) as starting material: haloalkynes (0.5 mmol), AgF (5 mol%), and water (1 eq.) were dissolved in trifluoroacetic acid (TFA, 1 mL), and the reaction was stirred for 6 hr at 40 °C. Upon completion of the reaction, TFA was recovered by distillation for reuse. The residue was purified by column chromatographic separation to afford the target product 2-bromo-4'-nitroacetophenone in pure form.
Purification Methods
Crystallise it from *C6H6/pet ether. [Beilstein 7 IV 661.]
References
[1] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375
[2] Chinese Journal of Chemistry, 2016, vol. 34, # 12, p. 1251 - 1254
[3] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986
2-Bromo-4'-nitroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 259)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Zhuoyu Yantang Technology Co., Ltd. | +8613288715578 | sales@sichuanzyyt.com | China | 12247 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20175 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
View Lastest Price from 2-Bromo-4'-nitroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | 2-Bromo-4'-nitroacetophenone
99-81-0
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-09-08 | 2-Bromo-4′ -Nitroacetophenone
99-81-0
|
US $0.00-0.00 / KG | 1KG | 99% | 50000KG/month | Sichuan Zhuoyu Yantang Technology Co., Ltd. | |
 |
2020-02-26 | 2-Bromo-4'-nitroacetophenone
99-81-0
|
US $0.00-0.00 / KG | 1KG | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-Bromo-4'-nitroacetophenone
99-81-0
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Bromo-4′ -Nitroacetophenone
99-81-0
- US $0.00-0.00 / KG
- 99%
- Sichuan Zhuoyu Yantang Technology Co., Ltd.
-
- 2-Bromo-4'-nitroacetophenone
99-81-0
- US $0.00-0.00 / KG
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
99-81-0(2-Bromo-4'-nitroacetophenone)Related Search:
ASISCHEM D48949
4'-NITROPHENACYL BROMIDE
4-NITROPHENACYL BROMIDE
AKOS BBS-00003952
ALPHA-BROMO-P-NITROACETOPHENONE
ALPHA-BROMO-4-NITROACETOPHENONE
A-BROMO-P-NITROACETOPHENONE
2-BROMO-4'-NITROACENTOPHENONE
2-BroMo-4'-nitroacetonphenone
2-Bromo-1-(4-nitrophenyl)ethan-1-one, 2-Bromo-4'-nitroacetophenone
2-BroMo-4'-nitroacetophenone 95%
α- broMo Nitroacetophenone
4-Nitrophecyl bromide
2-BROMO-1-(4-NITROPHENYL)ETHAN-1-ONE
2-BROMO-1-(4-NITROPHENYL)ETHANONE
2-Bromo-p-nitroacetophenone
4'-Nitro-2-bromoacetophenone
Acetophenone, 2-bromo-4'-nitro-
Acetophenone, 2'-bromo-p-nitro-
Ethanone, 2-bromo-1-(4-nitrophenyl)-
omega-Bromo-p-nitroacetophenone
p-Nitro-alpha-bromoacetophenone
OMEGA-BROMO-4-NITROACETOPHENONE
P-NITROPHENACYL BROMIDE
2-Bromo-4'-Nitroacetophenone 4'-Nitrophenacyl Bromide 2-Bromo-1-(4-Nitrophenyl)ethan-1-one
A-BROMO-4-NITROACETOPHENONE
à-bromo-4-nitroacetophenone
ω-bromo-4-nitroacetophenone
-bromo-4&rsquo
ω-Bromo-4-nitroacetophenone, 4-Nitrophenacyl bromide
2-Bromo-4'-nitroacetophenone ,98%
4'-Nitro-ω-bromoacetophenone
2-Bromo-4'-nitroacetophenone,95%
2-Bromo-4′-nitroacetophenone,ω-Bromo-4-nitroacetophenone, 4-Nitrophenacyl bromide
2-Bromo-1-(4-nitrophenyl)ethan-1-one, TECH
-methoxyacetophenone, 97.0 +%
1,3-Bis(2&rsquo
-cyano-phenoxy)propane
4-Nitrophenacyl bromide 98%
-(imidazol-1-yl)acetophenone
2-Bromo-4'-nitroacetophenone>
2-Bromo-4'-nitroacetophenone, 98%, for synthesis
α-Bromo-4-nitroacetophenone
2-Bromo-4'-nitroacetophenone ISO 9001：2015 REACH
2-Bromo-4'-nitroacetophenone
2-Bromo-4′-nitroacetophenone, CAS 99-81-0
2-Bromo-4'-nitroacetophenone
99-81-0
C8H6BrNO3
O2NC6H4COCH2Br
Ketones
Organic Building Blocks
KETONE
Building Blocks
C7 to C8
Carbonyl Compounds
B
Bioactive Small Molecules
