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4-[4-(Trifluoromethoxy)phenoxy]piperidine

4-[4-(Trifluoromethoxy)phenoxy]piperidine Structure
4-[4-(Trifluoromethoxy)phenoxy]piperidine structure
CAS No.
287952-67-4
Chemical Name:
4-[4-(Trifluoromethoxy)phenoxy]piperidine
Synonyms
Delamanid intermediate;Piperidine, 4-[4-(trifluoroMethoxy)phenoxy]-;4-[4-(TrifluoroMethoxy)phenoxy]piperidine HCl
CBNumber:
CB31476863
Molecular Formula:
C12H14F3NO2
Molecular Weight:
261.24
MDL Number:
MFCD06656166
MOL File:
287952-67-4.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:39
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4-[4-(Trifluoromethoxy)phenoxy]piperidine Properties

Melting point 71-73℃
Boiling point 292.2±40.0 °C(Predicted)
Density 1.230±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
form powder to crystal
pka 9.65±0.10(Predicted)
color White to Light yellow
InChI InChI=1S/C12H14F3NO2/c13-12(14,15)18-11-3-1-9(2-4-11)17-10-5-7-16-8-6-10/h1-4,10,16H,5-8H2
InChIKey RPQOTFPZKNHYFB-UHFFFAOYSA-N
SMILES N1CCC(OC2=CC=C(OC(F)(F)F)C=C2)CC1
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xn
Risk Statements  22
HS Code  2933.39.9200
HazardClass  IRRITANT
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
1
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4-[4-(Trifluoromethoxy)phenoxy]piperidine price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich MNO000104 4-[4-(Trifluoromethoxy)phenoxy]piperidine Aldrich 287952-67-4 1g $230 2026-04-30 Buy
TCI Chemical T3349 4-[4-(Trifluoromethoxy)phenoxy]piperidine >97.0%(GC)(T) 287952-67-4 1g $58 2026-04-30 Buy
TCI Chemical T3349 4-[4-(Trifluoromethoxy)phenoxy]piperidine >97.0%(GC)(T) 287952-67-4 5g $196 2026-04-30 Buy
TRC TRC-T790890-5G 4-[4-(Trifluoromethoxy)phenoxy]piperidine 287952-67-4 5g $522 2026-06-03 Buy
TRC TRC-T790890-25G 4-[4-(Trifluoromethoxy)phenoxy]piperidine 287952-67-4 25g $1628 2026-06-03 Buy
Product number Packaging Price Buy
MNO000104 1g $230 Buy
T3349 1g $58 Buy
T3349 5g $196 Buy
TRC-T790890-5G 5g $522 Buy
TRC-T790890-25G 25g $1628 Buy

4-[4-(Trifluoromethoxy)phenoxy]piperidine Chemical Properties,Uses,Production

Uses

4-[4-(Trifluoromethoxy)phenoxy]piperidine is used in the preparation of 3,5-disubstituted isoxazolines as antituberculosis agents.

Synthesis

p-Trifluoromethoxy phenol

828-27-3

Ethyl 4-hydroxypiperidine-1-carboxylate

65214-82-6

4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE

287952-67-4

GENERAL STEPS: 9.72 kg of ethyl 4-hydroxypiperidine-1-carboxylate and 10.0 L of triethylamine were dissolved in 15.0 L of toluene and the resulting solution was cooled to below 10 °C. To this solution, 7.07 kg of methanesulfonyl chloride was slowly added dropwise at a temperature below 25 °C, followed by continued stirring for 1 hour at below 25 °C. Next, 5.00 kg of 4-trifluoromethoxyphenol, 10 L of toluene, 17.7 L of 25% aqueous sodium hydroxide and 6.24 kg of 50% aqueous tetra-n-butyl ammonium chloride were added to the reaction solution. The mixture was heated to reflux for 2 hours (internal temperature was maintained at 88°C). After completion of the reaction, the mixture was cooled and the aqueous layer was separated and discarded. The organic layer was washed with 10 L of water. Subsequently, 14.2 kg of potassium hydroxide and 10 L of ethanol were added to the washed organic layer and the mixture was heated to reflux for 4 hours (internal temperature maintained at 98 °C). After cooling, concentration was carried out under reduced pressure. To the concentrated residue, 50 L of toluene was added and the organic layer was washed sequentially with 25 L of water, 25 L of brine and 31 L of aqueous ammonium chloride. The washed toluene solution was concentrated under reduced pressure. The concentrated residue was dissolved in a solvent mixture of 5 L of isopropanol, 50 L of water and 2.5 L of 25% aqueous sodium hydroxide to form a homogeneous solution, which was subsequently cooled to below 10 °C. After the crystals precipitated, stirring was continued below 10 °C for 1 h. The precipitate was then collected by filtration. The crystals were washed with 15 L of water and dried in air to give 6.67 kg of 4-(4-trifluoromethoxyphenoxy)piperidine (isolated yield: 90.9%). 1H-NMR (300 MHz, CDCl3) δ ppm: 1.41 (2H, dddd), 1.90 (2H, m), 2.55 (2H, dddd), 2.92 (2H, dddd), 3.33 (1H, brs), 4.39 (1H, tt), 7.03 (2H, d), 7.25 (2H, d).

References

[1] Patent: US2018/65931, 2018, A1. Location in patent: Paragraph 0135

4-[4-(Trifluoromethoxy)phenoxy]piperidine Preparation Products And Raw materials

Raw materials

1-Piperidinecarboxylic acid, 4-[4-(trifluoromethoxy)phenoxy]-, ethyl ester tert-Butyl 4-(4-(trifluoromethoxy)phenoxy)piperidine-1-carboxylate p-Trifluoromethoxy phenol Pyridine, 4-[4-(trifluoromethoxy)phenoxy]- 4-[(4-trifluoromethoxy)phenyl]methoxypiperidine-1-formic acid tert-butyl ester
Ethyl 4-hydroxypiperidine-1-carboxylate N-BOC-4-Hydroxypiperidine Triethylamine Sodium hydroxide Tetrabutyl ammonium chloride

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Preparation Products

1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine

4-[4-(Trifluoromethoxy)phenoxy]piperidine Suppliers

Global( 111)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Birch Chemical Technology Co., Ltd. 021-54096810 18017263450 sales@birchchem.com China 500 58
Changzhou Yanji Biotechnology Co., Ltd. 0519-83556355 18015005120 shikewei397@163.com China 3732 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ZHIWE CHEMTECH CO LTD 021-20221225 13917446399 zwchem@163.com China 529 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
HANSHANG CHEMICAL SCIENTIFIC LIMITED 021-50521775 15800962688 sales@hanshangchem.com China 471 57
Supplier Advantage
Shanghai Birch Chemical Technology Co., Ltd. 58
Changzhou Yanji Biotechnology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
ZHIWE CHEMTECH CO LTD 61
Alfa Aesar 84
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
HANSHANG CHEMICAL SCIENTIFIC LIMITED 57

View Lastest Price from 4-[4-(Trifluoromethoxy)phenoxy]piperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-[4-(trifluoromethoxy)phenoxy]piperidine pictures 2025-04-04 4-[4-(trifluoromethoxy)phenoxy]piperidine
287952-67-4
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE pictures 2019-12-27 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE
287952-67-4
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

4-[4-(Trifluoromethoxy)phenoxy]piperidine Spectrum

4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE(287952-67-4)1HNMR

287952-67-4(4-[4-(Trifluoromethoxy)phenoxy]piperidine)Related Search:

4-(4-Trifluoromethoxy-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester 4-[4-(Trifluoromethoxy)phenoxy]piperidine 4-(4-Methoxyphenoxy)piperidine 3-(4-(Trifluoromethoxy)phenoxy)propan-1-amine 4-(3-Fluoro-phenoxy)-piperidine
4-(4-Fluorophenoxy)piperidine

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Piperidine, 4-[4-(trifluoroMethoxy)phenoxy]- 4-[4-(TrifluoroMethoxy)phenoxy]piperidine HCl Delamanid intermediate 287952-67-4