MT-1207
- CAS No.
- 1610794-70-1
- Chemical Name:
- MT-1207
- Synonyms
- MT-1207;1H-Benzotriazole, 1-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-, hydrochloride (1:1)
- CBNumber:
- CB314907507
- Molecular Formula:
- C21H24N6S.ClH
- Molecular Weight:
- 428.98
- MDL Number:
- MOL File:
- 1610794-70-1.mol
- MSDS File:
- SDS
MT-1207 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41720 | MT-1207 (hydrochloride) ≥98% | 1610794-70-1 | 1mg | $29 | 2026-04-30 | Buy |
| Cayman Chemical | 41720 | MT-1207 (hydrochloride) ≥98% | 1610794-70-1 | 5mg | $137 | 2026-04-30 | Buy |
| Cayman Chemical | 41720 | MT-1207 (hydrochloride) ≥98% | 1610794-70-1 | 10mg | $229 | 2026-04-30 | Buy |
| Cayman Chemical | 41720 | MT-1207 (hydrochloride) ≥98% | 1610794-70-1 | 50mg | $715 | 2026-04-30 | Buy |
| ChemScene | CS-1171145 | MT-1207 99.96% | 1610794-70-1 | 5mg | $141 | 2026-06-04 | Buy |
MT-1207 Chemical Properties, Uses, Production
Uses
MT-1207 is an orally active and selective adrenergic α1 and 5-HT2A receptor antagonist. MT-1207 shows IC50<0.1 nM, 0.15 nM, 1.40 nM and 0.27 nM for α1A, α1B, α1D and 5-HT2A, respectively. MT-1207 achieves an effective blood pressure (BP) reduction in the 2K2C rat model without damaging renal function. MT-1207 is a potent multitarget inhibitor with the potential for vasodilatation research[1].
IC 50
α1A-adrenergic receptor: 0.1 nM (IC50); α1B-adrenergic receptor: 0.15 nM (IC50); α1B-adrenergic receptor: 1.40 nM (Ki); α1D-adrenergic receptor: 0.086 nM (IC50); α1D-adrenergic receptor: 0.69 nM (Ki); 5-HT2A Receptor: 0.27 nM (IC50); 5-HT2A Receptor: 0.079 nM (Ki)
References
[1] Peng Wang, et al. Discovery of MT-1207: A Novel, Potent Multitarget Inhibitor as a Promising Clinical Candidate for the Treatment of Hypertension. J Med Chem. 2024 Jul 5. DOI:10.1021/acs.jmedchem.4c00626
[2] TIAN-YING XU. Pharmacological characterization of MT-1207, a novel multitarget antihypertensive agent[J]. Acta Pharmacologica Sinica, 2021, 42 6: 885-897. DOI: 10.1038/s41401-021-00636-1
MT-1207 Preparation Products And Raw materials
Raw materials
Preparation Products
MT-1207 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| TargetMol Chemicals Inc. | 58 |
