3-Bromophthalide
- CAS No.
- 6940-49-4
- Chemical Name:
- 3-Bromophthalide
- Synonyms
- BROMOPHTHALIDE;TALM-002;3-BromophthaL;3-Bromophtalide;3-BROMOPHTHALIDE;3-bromophthalein;3-Bromophthalide97%;3-Bromophthalide 3-;3-Bromophthalide >3-BROMOPHTHALIDE 98+%
- CBNumber:
- CB3157574
- Molecular Formula:
- C8H5BrO2
- Molecular Weight:
- 213.03
- MDL Number:
- MFCD00040520
- MOL File:
- 6940-49-4.mol
- MSDS File:
- SDS
| Melting point | 86°C |
|---|---|
| Boiling point | 138 °C / 3mmHg |
| Density | 1.768±0.06 g/cm3(Predicted) |
| Flash point | >100° |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C8H5BrO2/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4,7H |
| InChIKey | CLMSHAWYULIVFQ-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC=C2)C(Br)O1 |
| CAS DataBase Reference | 6940-49-4(CAS DataBase Reference) |
| EPA Substance Registry System | 1(3H)-Isobenzofuranone, 3-bromo- (6940-49-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Risk Statements | 38-41 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2932209090 | |||||||||
| NFPA 704 |
|
3-Bromophthalide price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B1068 | 3-Bromophthalide >98.0%(T) | 6940-49-4 | 5g | $63 | 2026-04-30 | Buy |
| TCI Chemical | B1068 | 3-Bromophthalide >98.0%(T) | 6940-49-4 | 25g | $165 | 2026-04-30 | Buy |
| Biosynth | FB33933 | 3-Bromophthalide | 6940-49-4 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FB33933 | 3-Bromophthalide | 6940-49-4 | 10g | $150 | 2026-06-04 | Buy |
| Biosynth | FB33933 | 3-Bromophthalide | 6940-49-4 | 25g | $272 | 2026-06-04 | Buy |
3-Bromophthalide Chemical Properties, Uses, Production
Uses
3-Bromophthalide is a major intermediate in the synthesis of drugs such as tannic acid ester and phthalimide. Further hydrolysis of 3-bromophthalide can yield o-sylbenzaldehyde, which is an important intermediate in the synthesis of antipyretic analgesics.
Synthesis
3-Bromophthalide is produced by reacting phthalide with N-bromosuccinimide in carbon tetrachloride solution.
Ten grams (0.075 mole) of phthalide (Note 1), 13.3 g. (0.075 mole) of N-bromosuccinimide, and 200 ml. of dry carbon tetrachloride are refluxed for 30 minutes in a 500-ml. flask carrying a reflux condenser equipped with a drying tube containing Drierite. The reaction mixture is exposed to the light of an ordinary 100-watt unfrosted light bulb placed 6–8 in. from the flask. The end of the reaction is indicated by the disappearance of N-bromosuccinimide from the bottom of the flask and accumulation of succinimide at the top of the reaction mixture. The succinimide is removed by filtration and the filtrate concentrated under atmospheric pressure to 15–20 ml. Cooling of this concentrate followed by filtration gives 12–13 g. (75–81%) of crude 3-bromophthalide, m.p. 74–80°. The crude material, when recrystallized from cyclohexane, gives colorless plates, m.p. 78–80°.
References
[1] Patent: US4960902, 1990, A
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 7, p. 810 - 813
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 6, p. 455 - 457
[4] Synlett, 2003, # 5, p. 702 - 704
[5] Chemical and Pharmaceutical Bulletin, 1983, vol. 31, # 8, p. 2698 - 2707
3-Bromophthalide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. | 021-69106960 13701823997 | 13701823733@163.com | China | 4634 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from 3-Bromophthalide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 3-Bromophthalide
6940-49-4
|
1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
 |
2026-03-12 | Butyphthalide impurity 88
6940-49-4
|
10mg | 0.98 | 5g | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
 |
2021-10-09 | 3-Bromophthalide
6940-49-4
|
$10.00 | 1KG | 99% | 20 tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- 3-Bromophthalide
6940-49-4
- $0.00
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Butyphthalide impurity 88
6940-49-4
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- 3-Bromophthalide
6940-49-4
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
