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tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate structure

CAS No.: 167081-37-0

Chemical Name:: tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

Synonyms: trans-1-(Boc-aMino)-3-(hy...;tert-Butyl (trans-3-(hydroxymethyl);trans-3-(Boc-amino)cyclobutanemethanol;trans-3-(Boc-amino)cyclobutanemethanol,97%;trans-3-(Boc-aMino)cyclobutaneMethanol, 97%;BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE;trans-1-(Boc-aMino)-3-(hydroxyMethyl)cyclobutane;tert-butyl N-[3-(hydroxymethyl)cyclobutyl]carbamat;TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE;tert-butyl (1r,3r)-3-(hydroxymethyl)cyclobutylcarbamate

CBNumber:: CB3158733

Molecular Formula:: C10H19NO3

Molecular Weight:: 201.26

MDL Number:: MFCD08166748

MOL File:: 167081-37-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:02:57

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tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Properties

Boiling point	317.9±11.0 °C(Predicted)
Density	1.08±0.1 g/cm3(Predicted)
storage temp.	2-8°C, stored under nitrogen
pka	12.42±0.40(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-8-4-7(5-8)6-12/h7-8,12H,4-6H2,1-3H3,(H,11,13)/t7-,8-
InChIKey	PCPNTJQMXAHNOA-ZKCHVHJHSA-N
SMILES	C(OC(C)(C)C)(=O)N[C@@H]1C[C@@H](CO)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

HS Code

2922500090

NFPA 704

	1
0		0

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	266133	Tert-Butyl Trans-3-Hydroxymethylcyclobutylcarbamate Asreported	167081-37-0	25mg	$373	2026-06-03	Buy
Usbiological	266133	Tert-Butyl Trans-3-Hydroxymethylcyclobutylcarbamate Asreported	167081-37-0	50mg	$575	2026-06-03	Buy
Usbiological	266133	Tert-Butyl Trans-3-Hydroxymethylcyclobutylcarbamate Asreported	167081-37-0	100mg	$799	2026-06-03	Buy
Usbiological	266133	Tert-Butyl Trans-3-Hydroxymethylcyclobutylcarbamate Asreported	167081-37-0	250mg	$974	2026-06-03	Buy
Usbiological	266133	Tert-Butyl Trans-3-Hydroxymethylcyclobutylcarbamate Asreported	167081-37-0	500mg	$1351	2026-06-03	Buy

Product number	Packaging	Price	Buy
266133	25mg	$373	Buy
266133	50mg	$575	Buy
266133	100mg	$799	Buy
266133	250mg	$974	Buy
266133	500mg	$1351	Buy

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Chemical Properties, Uses, Production

Synthesis

To a stirred solution of methyl (1R,3R)-3-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate (1.0 g, 4.4 mmol) in THF (20 mL) was added 3M lithium borohydride (9 mL, 9 mmol) at 0° C. Then the reaction mixture was heated and stirred at 60° C for 3 h. The reaction mixture was then transferred into dilute NaOH and the resulting mixture was extracted using ethyl acetate (3×50 mL). The combined organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated under reduced pressure and the crude product was purified using silica gel column chromatography (3% MeOH-DCM) to give tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate as a white solid (0.8 g, 91%).

Reactions

Tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate is an crucial organic compound that can be used to synthesize 3-Amino-cyclobutaneMethanol hydrochloride.

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Suppliers

Global Suppliers ( 61)

Supplier	Tel	Email	Country	ProdList	Advantage
Yutong Pharmaceutical Technology (Suzhou) Co., Ltd.	0512-15851462628 15851462628	2680463261@qq.com	China	4996	58
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Shanghai Xiannuo Biotechnology Co., Ltd.	021-50718719 13918719472		China	978	58
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9509	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
Shanghai Run-Biotech Co., Ltd.	021-57171705 13817537615	sales@run-biotech.com	China	2277	58
Cool Pharm, Ltd	021-60455363 18019463053	sales@coolpharm.com	China	8455	58
SPIRO PHARMA		eric_feng1954@126.com	China	9239	55
Zhengzhou Alfachem Co., Ltd.	0371-53765687 18937137882	3969243885@qq.com	China	7734	55

Supplier	Advantage
Yutong Pharmaceutical Technology (Suzhou) Co., Ltd.	58
Alfa Aesar	84
Chemsky（shanghai）International Co.,Ltd.	50
Shanghai Xiannuo Biotechnology Co., Ltd.	58
Shanghai Topbiochem Technology Co., Ltd	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
Shanghai Run-Biotech Co., Ltd.	58
Cool Pharm, Ltd	58
SPIRO PHARMA	55
Zhengzhou Alfachem Co., Ltd.	55

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Spectrum

TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE(167081-37-0)¹HNMR

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trans-1-(Boc-aMino)-3-(hy... trans-1-(Boc-aMino)-3-(hydroxyMethyl)cyclobutane trans-3-(Boc-aMino)cyclobutaneMethanol, 97% BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE tert-Butyl (trans-3-(hydroxymethyl) TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE tert-butyl N-[trans-3-(hydroxymethyl)cyclobutyl]carbamate trans-1-(Boc-amino)-3-(hydroxymethyl)cyclobutane - SB7652 tert-butyl (1r,3r)-3-(hydroxymethyl)cyclobutylcarbamate Carbamic acid, [3-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester, trans- Carbamic acid, N-[trans-3-(hydroxymethyl)cyclobutyl]-, 1,1-dimethylethyl ester trans-3-(Boc-amino)cyclobutanemethanol,97% tert-butyl N-[3-(hydroxymethyl)cyclobutyl]carbamat trans-3-(Boc-amino)cyclobutanemethanol 1,1-Dimethylethyl N-[trans-3-(hydroxymethyl)cyclobutyl]carbamate 167081-37-0 167081-30-0 N-BOC