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ChemicalBook >> CAS DataBase List >>2-Methyl-4H-3,1-benzoxazin-4-one

2-Methyl-4H-3,1-benzoxazin-4-one

2-Methyl-4H-3,1-benzoxazin-4-one Structure
2-Methyl-4H-3,1-benzoxazin-4-one structure
CAS No.
525-76-8
Chemical Name:
2-Methyl-4H-3,1-benzoxazin-4-one
Synonyms
2-Methyl-4H-benzo[d][1,3]oxazin-4-one;NSC 10119;NSC 521353;ACETANTHRANIL;AURORA KA-3785;Acetylanthranyl;ACETYL ANTHRANIL;TIMTEC-BB SBB000135;2-METHYL-3,1-BENZOXAZA-4-ONE;2-methyl-3,1-benzoxazin-4-one
CBNumber:
CB3163296
Molecular Formula:
C9H7NO2
Molecular Weight:
161.16
MDL Number:
MFCD00047647
MOL File:
525-76-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-16 21:18:09
Request For Quotation

2-Methyl-4H-3,1-benzoxazin-4-one Properties

Melting point 79-82 °C(lit.)
Boiling point 144-145 °C(Press: 12 Torr)
Density 1.25±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 2.84±0.20(Predicted)
Appearance Light yellow to brown Solid
InChI InChI=1S/C9H7NO2/c1-6-10-8-5-3-2-4-7(8)9(11)12-6/h2-5H,1H3
InChIKey WMQSKECCMQRJRX-UHFFFAOYSA-N
SMILES N1C2=CC=CC=C2C(=O)OC=1C
FDA UNII Y938TMX1D8
EPA Substance Registry System 4H-3,1-Benzoxazin-4-one, 2-methyl- (525-76-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
TSCA  TSCA listed
HazardClass  IRRITANT
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

2-Methyl-4H-3,1-benzoxazin-4-one price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 457752 2-Methyl-4H-3,1-benzoxazin-4-one 98% 525-76-8 10g $69 2026-04-30 Buy
aablocks AA00DEI8 2-Methyl-4H-benzo[d][1,3]oxazin-4-one ≥95% 525-76-8 1g $31 2026-05-28 Buy
aablocks AA00DEI8 2-Methyl-4H-benzo[d][1,3]oxazin-4-one ≥95% 525-76-8 5g $103 2026-05-28 Buy
aablocks AA00DEI8 2-Methyl-4H-benzo[d][1,3]oxazin-4-one ≥95% 525-76-8 25g $392 2026-05-28 Buy
aablocks AA00DEI8 2-Methyl-4H-benzo[d][1,3]oxazin-4-one ≥95% 525-76-8 100g $1339 2026-05-28 Buy
Product number Packaging Price Buy
457752 10g $69 Buy
AA00DEI8 1g $31 Buy
AA00DEI8 5g $103 Buy
AA00DEI8 25g $392 Buy
AA00DEI8 100g $1339 Buy

2-Methyl-4H-3,1-benzoxazin-4-one Chemical Properties,Uses,Production

Chemical Properties

Neoacetamide benzoic acid lactone is a lactone that under appropriate conditions undergoes a variety of important organic synthesis reactions. It can be used to obtain the corresponding lactam derivatives by substitution reactions with organic amines at elevated temperatures.

Uses

2-Methyl-4H-3,1-benzoxazin-4-one is a synthetic antimicrobial agent. It belongs to the quinazolinone class of drugs. It has been shown to be effective against Staphylococcus aureus and other bacteria. Quinazolinones are potent inhibitors of bacterial growth and have been used successfully in the treatment of tuberculosis and other infectious diseases. 2-Methyl-4H-3,1-benzoxazin-4-one has also been shown to inhibit the growth of some Gram-negative bacteria, such as Salmonella typhi and Escherichia coli.

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 363, 1980 DOI: 10.1021/jo01290a038

Synthesis

In 250 mL of RBF took (0.01 mole or 1.37 gm) anthranilic acid (2-amino benzoic acid) to that added 15 mL of acetic anhydride (excess) with porcelain chips. Reflux the solution at 35-40 ℃ for 50-55 min on heating mantle. TLC was done using EA: n-hexane (1:1) solvent system. Then removed the excess solvent (acetic anhydride) at low pressure using rotatory evaporator, To the remaining solid, added petroleum ether (40-60) to extract the 2-methyl-4H-3,1-benzoxazin-4-one. Repeated petroleum ether step to extract the entire product. After drying of petroleum-ether, the crystals of 2-methyl-4H-3, 1-benzoxazin-4-one was obtained and then it was recrystallized with ethanol8. M.P 80-82℃, Yield 79 %.
2-METHYL-3,1-BENZOXAZA-4-ONE

2-Methyl-4H-3,1-benzoxazin-4-one synthesis

108-24-7
118-92-3
525-76-8
Synthesis of 2-Methyl-4H-3,1-benzoxazin-4-one from Acetic anhydride and Anthranilic acid

2-Methyl-4H-3,1-benzoxazin-4-one Preparation Products And Raw materials

Raw materials

2'-IODOACETANILIDE N-(2-ACETYL-PHENYL)-ACETAMIDE 2-Azidobenzoic acid PHENYL FORMATE carbon monoxide
Acetyl chloride N-Acetylanthranilic acid Methyl anthranilate 2-Iodoaniline Anthranilic acid

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Preparation Products

1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER METHAQUALONE

2-Methyl-4H-3,1-benzoxazin-4-one Suppliers

Global( 125)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Yingwen Biotechnology Co., Ltd. 19880631625 3067892485@qq.com China 1 58
Marvel pharm limited +86-13302302478 13302302478 Mia@marvelpharm.com China 22 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Shijiazhuang Ruitian Biochemical Co. Ltd 15831127780 52714113@qq.com China 2354 58
Nanjing webright Pharmaceutical Technology Co., Ltd 18066048793; 18014498793 1504914633@qq.com China 1621 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Shanghai Yolne Chemical Co., Ltd. 021-62960152 934678158@qq.com China 9886 55
Conier Chem & Pharma Co.,Ltd, 023-62879767 sales@conier.com China 289 56
Supplier Advantage
Nanjing Yingwen Biotechnology Co., Ltd. 58
Marvel pharm limited 58
Nanjing Norris-Pharm Technology Co., Ltd 55
Shijiazhuang Ruitian Biochemical Co. Ltd 58
Nanjing webright Pharmaceutical Technology Co., Ltd 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Shanghai Hanhong Scientific Co.,Ltd. 64
Syntechem Co.,Ltd 57
Shanghai Yolne Chemical Co., Ltd. 55
Conier Chem & Pharma Co.,Ltd, 56

View Lastest Price from 2-Methyl-4H-3,1-benzoxazin-4-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-METHYL-3,1-BENZOXAZA-4-ONE pictures 2026-09-12 2-METHYL-3,1-BENZOXAZA-4-ONE
525-76-8
 0.99 RongNa Biotechnology Co.,Ltd
2-Methyl-4H-3,1-benzoxazin-4-one pictures 2026-09-02 2-Methyl-4H-3,1-benzoxazin-4-one
525-76-8
 $1.20-34.00 1kg 99% Henan Fengda Chemical Co., Ltd
2-Methyl-4H-3,1-benzoxazin-4-one pictures 2026-06-30 2-Methyl-4H-3,1-benzoxazin-4-one
525-76-8
 1KG 95% 20Tons Shaanxi Dideu New Materials Co. Ltd

525-76-8(2-Methyl-4H-3,1-benzoxazin-4-one)Related Search:

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TIMTEC-BB SBB000135 2-methyl-4h-1-benzoxazin-4-one 3-methyl-1-phenyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-dione 2-METHYL-3,1-BENZOXAZA-4-ONE 2-METHYL-4H-3,1-BENZOXAZIN-4-ONE ACETYL ANTHRANIL ACETANTHRANIL 2-2-METHYL-4H-3,1-BENZOXAZIN-4-ONE 4H-3,1-benzoxazin-4-one, 2-methyl- 2-methyl-3,1-benzoxazin-4-one 2-Methyl-benzo(d)(1,3)oxazin-4-one 2-Methyl-3,1-benzoxazine-4-one 2-Methyl-4-oxo-3,1-benzoxazine 2-Methyl-4-oxo-4H-3,1-benzoxazine 2-Methylbenzo[1,3]oxazin-4-one Acetylanthranyl NSC 10119 NSC 521353 2-Methyl-4H-3,1-benzoxazin-4-one 98% 2-Methyl-4H-3,1-benzoxazin-4-o 2-Methylbenzisoxazinone(2-Methyl-4H-3,1-Benzoxazin-4-One) AURORA KA-3785 Ortho acetamide benzoic acid lactone 2-Methyl-4H-benzo [d] [1,3]oxazin-4o 2-Methyl-4H-3,1-benzoxazin-4-one 2-Methyl-4H-benzo[d][1,3]oxazin-4-one 525-76-8 Benzoxazines Building Blocks Heterocyclic Building Blocks API intermediates Benzoxazines Building Blocks Heterocyclic Building Blocks 525-76-8