2-Bromo-4-methoxy-5-(benzyloxy)benzaldehyde
- CAS No.
- 6451-86-1
- Chemical Name:
- 2-Bromo-4-methoxy-5-(benzyloxy)benzaldehyde
- Synonyms
- 2-Bromo-4-methoxy-5-;6-BROMOBENZYL ISOVANILLIN;Benzaldehyde,2-broMo-4-Methoxy-5-(;Valproic Acid Impurity 46 Sodium salt;2-broMo-4-Methoxy-benzyloxybenzaldehyde;5-Benzyl-2-bromo-4-methoxylbenzaldehyde;5-BENZYLOXY-2-BROMO-4-METHOXY-BENZALDEHYDE;2-BROMO-4-METHOXY-5-(BENZYLOXY)BENZALDEHYDE;Benzaldehyde, 2-bromo-4-methoxy-5-(phenylmethoxy)-
- CBNumber:
- CB3197910
- Molecular Formula:
- C15H13BrO3
- Molecular Weight:
- 321.17
- MDL Number:
- MFCD00666893
- MOL File:
- 6451-86-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Bromo-4-methoxy-5-benzyloxybenzaldehyde | 121505 | 5.00g | $1120 |
| 2-Bromo-4-methoxy-5-benzyloxybenzaldehyde | 121505 | 25.00g | $1920 |
| 5-Benzyloxy-2-bromo-4-methoxybenzaldehyde 97% | B58212 | 250mg | $44 |
| 5-Benzyloxy-2-bromo-4-methoxybenzaldehyde 97% | B58212 | 1g | $50 |
| 5-Benzyloxy-2-bromo-4-methoxybenzaldehyde 97% | B58212 | 5g | $150 |
| More product size | |||
| Melting point | 142.4-143.3 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6)) |
|---|---|
| Boiling point | 427.5±40.0 °C(Predicted) |
| Density | 1.421±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 6451-86-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-Bromo-4-methoxy-5-(benzyloxy)benzaldehyde price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 121505 | 2-Bromo-4-methoxy-5-benzyloxybenzaldehyde | 6451-86-1 | 5.00g | $1120 | 2026-05-18 | Buy |
| Matrix Scientific | 121505 | 2-Bromo-4-methoxy-5-benzyloxybenzaldehyde | 6451-86-1 | 25.00g | $1920 | 2026-05-18 | Buy |
| Synthonix | B58212 | 5-Benzyloxy-2-bromo-4-methoxybenzaldehyde 97% | 6451-86-1 | 250mg | $44 | 2026-05-06 | Buy |
| Synthonix | B58212 | 5-Benzyloxy-2-bromo-4-methoxybenzaldehyde 97% | 6451-86-1 | 1g | $50 | 2026-05-06 | Buy |
| Synthonix | B58212 | 5-Benzyloxy-2-bromo-4-methoxybenzaldehyde 97% | 6451-86-1 | 5g | $150 | 2026-05-06 | Buy |
2-Bromo-4-methoxy-5-(benzyloxy)benzaldehyde Chemical Properties,Uses,Production
Uses
6-Bromobenzylisovanillin is an intermediate in the synthesis of 3,8-Dihydroxy-9-methoxy-6H-Dibenzo[b,d]pyran-6-one (D455545) which has been used in anti-wrinkle agents and is known as a collagen production promoter, MMP-1 production inhibitor and elastase activity inhibitor containing urolithin.
Synthesis
2973-59-3
100-39-0
6451-86-1
Under nitrogen protection, 2-bromo-5-hydroxy-4-methoxybenzaldehyde (8.70 mmol) was dissolved in 87 mL (0.1 M) of N,N-dimethylformamide (DMF) and cooled to 0 °C. Potassium carbonate (13.1 mmol, 1.8 g) and benzyl bromide (10.4 mmol, 1.77 g) were then added sequentially. The reaction mixture was slowly warmed to 25 °C and the reaction was stirred at this temperature for 5 hours. Upon completion of the reaction, the mixture was poured into 100 mL of aqueous ammonium chloride solution to quench the reaction. The reaction mixture was extracted with ethyl acetate (3 x 30 mL) and the organic layers were combined. The organic layer was washed with saturated saline (10 mL × 2), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 2-bromo-4-methoxy-5-benzyloxybenzaldehyde (5-(benzyloxy)-2-bromo-4-methoxybenzaldehyde) 2.73 g (8.53 mmol, 98% yield).
References
[1] Patent: KR101492960, 2015, B1. Location in patent: Paragraph 0092-0094
[2] Tetrahedron, 2006, vol. 62, # 51, p. 12098 - 12107
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 8, p. 1289 - 1292
[4] Patent: US2006/257337, 2006, A1. Location in patent: Page/Page column 16-17
[5] Patent: WO2016/29214, 2016, A1. Location in patent: Page/Page column 145
2-Bromo-4-methoxy-5-(benzyloxy)benzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3971 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
