2-Amino-5-iodo-3-nitropyridine
- CAS No.
- 25391-57-5
- Chemical Name:
- 2-Amino-5-iodo-3-nitropyridine
- Synonyms
- 5-iodo-3-nitropyridin-2-aMine;Zinc04202918;5-iodo-3-nitro-2-pyridinamine;2-PYRIDINAMINE,5-IODO-3-NITRO;2-Amino-5-iodo-3-nitropyridine;2-Amino-3-nitro-5-iodopyridine;5-IODO-3-NITRO-PYRIDIN-2-YLAMINE;2-Amino-5-iodo-3-nitropyridine 95+%;2-AMINO-5-IODO-3-NITROPYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB3203020
- Molecular Formula:
- C5H4IN3O2
- Molecular Weight:
- 265.01
- MDL Number:
- MFCD04038464
- MOL File:
- 25391-57-5.mol
- MSDS File:
- SDS
| Melting point | 215-219 °C (lit.) |
|---|---|
| Boiling point | 365.4±42.0 °C(Predicted) |
| Density | 2.229±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 0.41±0.49(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | 1S/C5H4IN3O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H,(H2,7,8) |
| InChIKey | MDJUWRHSXKZSOJ-UHFFFAOYSA-N |
| SMILES | Nc1ncc(I)cc1[N+]([O-])=O |
| CAS DataBase Reference | 25391-57-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H317-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-43 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
2-Amino-5-iodo-3-nitropyridine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 260460 | 2-Amino-5-iodo-3-nitropyridine Asreported | 25391-57-5 | 1g | $356 | 2026-06-03 | Buy |
| Usbiological | 260460 | 2-Amino-5-iodo-3-nitropyridine Asreported | 25391-57-5 | 2g | $511 | 2026-06-03 | Buy |
| Usbiological | 260460 | 2-Amino-5-iodo-3-nitropyridine Asreported | 25391-57-5 | 5g | $758 | 2026-06-03 | Buy |
| Usbiological | 260460 | 2-Amino-5-iodo-3-nitropyridine Asreported | 25391-57-5 | 10g | $1068 | 2026-06-03 | Buy |
| Usbiological | 260460 | 2-Amino-5-iodo-3-nitropyridine Asreported | 25391-57-5 | 25g | $1663 | 2026-06-03 | Buy |
2-Amino-5-iodo-3-nitropyridine Chemical Properties,Uses,Production
Uses
2-Amino-5-iodo-3-nitropyridine is used in the synthetic preparation of disubstituted pyridinyl azabicyclo heptanes as epibatidine analogs. These analogs are evaluated for its affinity for nicotinic acetylcholine receptors via in vitro and antinociceptive properties via in vivo in rats.
Synthesis
4214-75-9
25391-57-5
To a 250 mL three-necked flask were added 2-amino-3-nitropyridine (10.0 g, 72.0 mmol), acetic acid (44 mL) and water (10 mL). The mixture was heated to 90°C and then periodic acid (3.28 g, 14.4 mmol) and concentrated sulfuric acid (1.3 mL) at a mass percent concentration of 98% were added sequentially. After stirring for 10 min, iodine (9.1 g, 36.0 mmol) was added and stirring was continued for 60 min at this temperature. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently poured into saturated aqueous sodium thiosulfate solution (100 mL). The solid product was separated by filtration and washed sequentially with saturated brine (50 mL x 2) and petroleum ether (50 mL x 2). The crude product was recrystallized using a mixed solvent of petroleum ether and ethyl acetate (5:1, v/v) to afford a high purity yellow solid 2-amino-5-iodo-3-nitropyridine (17.57 g, 69.1 mmol, 96% yield).
References
[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 21, p. 4755 - 4761
[2] Patent: CN107325045, 2017, A. Location in patent: Paragraph 0006; 0009
[3] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 37
[4] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0152
2-Amino-5-iodo-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nanjing Duolong Bio-tech Co.,Ltd. | 18905173768 | 52513593@qq.com | China | 2337 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| Suzhou Xinkai Bio-Medical Technology Co., Ltd. | 0512-67213637 13952409868 | peter19zhang@163.com | China | 442 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Lastest Price from 2-Amino-5-iodo-3-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-AMINO-5-IODO-3-NITROPYRIDINE
25391-57-5
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-02-01 | 2-AMINO-5-IODO-3-NITROPYRIDINE
25391-57-5
|
$1.00 | 1KG | 99% | 200kgs | Career Henan Chemical Co |
-
- 2-AMINO-5-IODO-3-NITROPYRIDINE
25391-57-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-AMINO-5-IODO-3-NITROPYRIDINE
25391-57-5
- $1.00
- 99%
- Career Henan Chemical Co
