Resorufin ethyl ether
- CAS No.
- 5725-91-7
- Chemical Name:
- Resorufin ethyl ether
- Synonyms
- ETHOXYRESORUFIN;7-ETHOXYRESORUFIN;7-ER;O7-ETHYLRESORUFIN;7-Ethoxy Rresorufin;7-Ethoxyphenoxazone;RESORUFIN ETHYL ESTER;Resorufin ethyl ether;7-ethoxyphenoxazin-3-one;Thiabendazole Impurity 19
- CBNumber:
- CB3203954
- Molecular Formula:
- C14H11NO3
- Molecular Weight:
- 241.24
- MDL Number:
- MFCD00037661
- MOL File:
- 5725-91-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 223-225 °C (lit.) |
|---|---|
| Boiling point | 389.3±42.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: soluble |
| form | Brown solid. |
| pka | 1.43±0.20(Predicted) |
| color | Dark Orange to Red |
| BRN | 225973 |
| InChIKey | ZOSYTBPPLWBBKM-UHFFFAOYSA-N |
| SMILES | CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F |
| FDA UNII | 59AF853SW7 |
| UNSPSC Code | 12161501 |
| NACRES | NA.47 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| F | 8-10 |
| Storage Class | 11 - Combustible Solids |
Resorufin ethyl ether price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 46121 | Resorufin ethyl ether suitable for fluorescence, ≥95% (UV) | 5725-91-7 | 5mg | $478 | 2026-04-30 | Buy |
| Sigma-Aldrich | 46121 | Resorufin ethyl ether suitable for fluorescence, ≥95% (UV) | 5725-91-7 | 25mg | $1860 | 2026-04-30 | Buy |
| Cayman Chemical | 16122 | 7-Ethoxyresorufin ≥95% | 5725-91-7 | 1mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 16122 | 7-Ethoxyresorufin ≥95% | 5725-91-7 | 10mg | $190 | 2026-04-30 | Buy |
| Usbiological | E8577-60 | 7-Ethoxyresorufin (7-Ethoxy-3H-phenoxazin-3-one, Resorufin Ethyl Ester) ~90% | 5725-91-7 | 10mg | $389 | 2026-06-03 | Buy |
Resorufin ethyl ether Chemical Properties, Uses, Production
Chemical Properties
Red Solid
Uses
A fluorimetric substrate for cytochrome P450 IAI. Inhibits vasorelaxant responses to acetylcholine
Uses
Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450.
Uses
Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A′-acetylcysteine conjugates are used as inhibitors. It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).
Definition
ChEBI: 7-ethoxyresorufin is a phenoxazine.
General Description
Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.
Biological Activity
cytochrome p450, family 1, subfamily a, polypeptide 1 is a protein that is encoded by human cyp1a1 gene. the protein is a member of the cytochrome p450 superfamily of enzymes. cyp1a1 is involved in phase i xenobiotic and drug metabolism. cyp1a1 is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons. 7-ethoxyresorufin is a specific subtrate of cyp1a.
in vitro
7-ethoxyresorufin (2-10 microm), a substrate for cytochrome p450, which binds to the heme moiety of the enzyme, reduced responses to acetylcholine concentration-dependently but not the other agonists indicating an effect on nitric oxide synthesis although neither affected the conversion of l-arginine to l-citrulline [1].
in vivo
activities of cyp1a (7-ethoxyresorufin) in the liver was determined for comparative purposes. in mice, lps depressed cyp2a5 at low doses but not at doses that increased pro-inflammatory cytokines and no serum levels, and depressed cyp1a activity. blockade of proinflammatory cytokines extended down-regulation of cyp2a5 while not affecting lps-induced depression of cyp1a [2].
storage
Store at -20°C
References
[1] oyekan ao, mcgiff jc, rosencrantz-weiss p, quilley j. relaxant responses of rabbit aorta: influence of cytochrome p450 inhibitors. j pharmacol exp ther. 1994 jan;268(1):262-9.
[2] de-oliveira ac, poça ks, totino pr, paumgartten fj. modulation of cytochrome p450 2a5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship. plos one. 2015 jan 30;10(1):e0117842.
[3] pelkonen o, pasanen m, kuha h, gachalyi b, kairaluoma m, sotaniemi ea, park ss, friedman fk, gelboin hv. the effect of cigarette smoking on 7-ethoxyresorufin o-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. br j clin pharmacol. 1986 aug;22(2):125-34.
Resorufin ethyl ether Preparation Products And Raw materials
Resorufin ethyl ether Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
View Latest Price from Resorufin ethyl ether manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | 7-Ethoxyresorufin
5725-91-7
|
$30.00-61.00 | 99.62% | 10g | TargetMol Chemicals Inc. |
-
- 7-Ethoxyresorufin
5725-91-7
- $30.00-61.00
- 99.62%
- TargetMol Chemicals Inc.
