Neosperidin dihydrochalcone

Neosperidin dihydrochalcone Properties

Melting point	156-158 °C(lit.)
Boiling point	927.1±65.0 °C(Predicted)
Density	1.61±0.1 g/cm3(Predicted)
vapor pressure	0Pa at 20℃
FEMA	3811 \| NEOHESPERIDIN DIHYDROCHALCONE
FLAVIS Number	16.061 \| Neohesperidin dihydrochalcone
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Practically insoluble in water, freely soluble in dimethyl sulfoxide, soluble in methanol, practically insoluble in methylene chloride.
form	crystalline
pka	6.85±0.40(Predicted)
color	light yellow
Odor	at 100.00 %. bland odor
Odor Type	odorless
biological source	synthetic
Water Solubility	Insoluble
Merck	14,6452
Stability	Hygroscopic
Major Application	flavors and fragrances
Cosmetics Ingredients Functions	FLAVOURING FRAGRANCE PERFUMING
InChIKey	ITVGXXMINPYUHD-CUVHLRMHSA-N
SMILES	COc1ccc(CCC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)cc2O)cc1O
LogP	0.67 at 20℃
CAS DataBase Reference	20702-77-6(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	NEOHESPERIDIN DIHYDROCHALCONE
EWG's Food Scores	1
FDA UNII	3X476D83QV
EPA Substance Registry System	Neohesperidin dihydrochalcone (20702-77-6)
UNSPSC Code	85151701
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

PPE

Eyeshields, Gloves, type N95 (US)

WGK Germany

3

RTECS

LZ5785000

HS Code

29389090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

REACH Registrations

Active

NFPA 704

	0
2		0

Neosperidin dihydrochalcone price More Price(84)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W381101	Neohesperidin dihydrochalcone ≥96%, FG	20702-77-6	1 each	$58	2026-04-30	Buy
Sigma-Aldrich	W381101	Neohesperidin dihydrochalcone ≥96%, FG	20702-77-6	25g	$83.9	2026-04-30	Buy
Sigma-Aldrich	W381101	Neohesperidin dihydrochalcone ≥96%, FG	20702-77-6	100g	$136	2026-04-30	Buy
Sigma-Aldrich	N0399000	Neohesperidin dihydrochalcone European Pharmacopoeia (EP) Reference Standard	20702-77-6	125 mg	$167	2026-04-30	Buy
Sigma-Aldrich	75041	Neohesperidin dihydrochalcone analytical standard	20702-77-6	100mg	$110	2026-04-30	Buy

Product number	Packaging	Price	Buy
W381101	1 each	$58	Buy
W381101	25g	$83.9	Buy
W381101	100g	$136	Buy
N0399000	125 mg	$167	Buy
75041	100mg	$110	Buy

Neosperidin dihydrochalcone Chemical Properties, Uses, Production

Chemical Properties

Neohesperidin dihydrochalcone occurs as a white or yellowish white powder with an intensely sweet taste. The sweetness is about 1500-1800 times that of sucrose, and its sweetness time is slightly later than saccharin sodium and much faster than glycyrrhizin (5:7:23s). The sweetness retention time of the three is 42:57:133s, which is also between Between the two, it is closer to sodium saccharin. It is soluble in water, slightly soluble in ethanol, but insoluble in ether and benzene.

Uses

Preparation from Naringen, a flavanone glycoside occurring naturally in grapefruit. It is used as sweetening agent, especially in chewing gum and dentifrices.

Uses

Neohesperidin dihydrochalcone hydrate, is a flavonoid sweetening agent with potent antioxidant activity. It is antioxidant agent. artificial sweetener, especially in chewing gum and dentifrices.

Production Methods

Neohesperidin dihydrochalcone is synthesized commercially from either of the bitter-flavanones neohesperidin or naringin by catalytic hydrogenation under alkaline conditions in a process first described in the 1960s, in which neohesperidin is purified by recrystallization from water solutions.Neohesperidin dihydrochalcone is obtained by the alkaline hydrogenation of neohesperidin.

Preparation

Neosperidin dihydrochalcone is produced from Neohespendin (an isomer of Hesperidin), derived from the peel of the Seville Orange.

Definition

ChEBI: Neohesperidin dihydrochalcone is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange. It has a role as an environmental contaminant, a xenobiotic, a plant metabolite and a sweetening agent. It is a neohesperidoside, a disaccharide derivative and a member of dihydrochalcones.

General Description

Off-white crystals or powder. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Neosperidin dihydrochalcone is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Fire Hazard

The flash point of Neosperidin dihydrochalcone has not been determined, but Neosperidin dihydrochalcone is probably combustible.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Neohesperidin dihydrochalcone is a synthetic intense sweetening agent approximately 1500–1800 times sweeter than sucrose and 20 times sweeter than saccharin. Structurally it is an analogue of neohesperidin, a flavanone that occurs naturally in Seville oranges (Citrus aurantium). Neohesperidin dihydrochalcone is used in pharmaceutical and food applications as a sweetening agent and flavor enhancer. The sweetness profile is characterized by a lingering sweet/menthol-like aftertaste.The typical level used in foods is 1–5 ppm although much higher levels may be used in certain applications such as chewing gum. Synergistic effects occur with other intense and bulk sweeteners such as acesulfame K, aspartame, polyols, and saccharin.
In pharmaceutical applications, neohesperidin dihydrochalcone is useful in masking the unpleasant bitter taste of a number of drugs such as antacids, antibiotics, and vitamins. In antacid preparations, levels of 10–30 ppm result in improved palatability.

Biological Activity

Flavonoid sweetening agent with potent antioxidant activity.

Safety

Neohesperidin dihydrochalcone is accepted for use in food products either as a sweetener or flavor modifier in a number of areas including Europe, USA, Australia, New Zealand, and several countries in Africa and Asia. It is also used in a number of oral pharmaceutical formulations.
Animal toxicity studies suggest that neohesperidin dihydrochalcone is a nontoxic, nonteratogenic, and noncarcinogenic material at the levels used in foods and pharmaceuticals.In Europe, an acceptable daily intake of 0–5 mg/kg body-weight has been established.

storage

Neohesperidin dihydrochalcone is stable for over three years when stored at room temperature.
Accelerated stability studies on aqueous solutions stored at 30–60°C and pH 1–7 for 140 days indicate that neohesperidin dihydrochalcone solutions are likely to be stable for 12 months at room temperature and pH 2–6.Solutions formulated with some or all of the water replaced by solvents with a lower dielectric constant are reported to have longer shelf-lives.
The bulk material should be stored in a cool, dry, place protected from light.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe.

Neosperidin dihydrochalcone Preparation Products And Raw materials

Raw materials

Hesperetin Neohesperidin Naringin

Preparation Products

Neosperidin dihydrochalcone Suppliers

Global Suppliers ( 613)

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan Benepure Pharmaceutical Co., Ltd.	028-028-86798880 13308041363	online@benepure.com	China	232	58
Hefei Chaobo Technology Co., Ltd	19322001459	zb19922001456@163.com	China	438	58
Hubei ZhongKe XinChen Technology Ltd.	欢迎详询+微信 18827688560	starvips@qq.com	China	496	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Sichuan Benepure Pharmaceutical Co., Ltd.	58
Hefei Chaobo Technology Co., Ltd	58
Hubei ZhongKe XinChen Technology Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
future industrial shanghai co., ltd	65
Chembest Research Laboratories Limited	61
TCI (Shanghai) Development Co., Ltd.	81

View Latest Price from Neosperidin dihydrochalcone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-20	Neosperidin dihydrochalcone 20702-77-6	$300.00-500.00	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-09-20	Neosperidin dihydrochalcone 20702-77-6		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-20	Neosperidin dihydrochalcone 20702-77-6		1KG	≥98% HPLC	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.

Neosperidin dihydrochalcone
20702-77-6
$300.00-500.00
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Neosperidin dihydrochalcone
20702-77-6
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Neosperidin dihydrochalcone
20702-77-6
$0.00
≥98% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Neosperidin dihydrochalcone Spectrum

Neosperidin dihydrochalcone(20702-77-6)MS Neosperidin dihydrochalcone(20702-77-6)¹HNMR Neosperidin dihydrochalcone(20702-77-6)IR1

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Neohesperidin dihydrochalcone ,EP Neohesperidin dihydrochalcone, froM Citrus MaxiMa Newhesperidinchalconetwohydrogen Neohesperidin dihydrochalcone SynonyMs 1-(4-((2-O-[6-Deoxy-alpha-L-Mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-Methoxyphenyl]-1-propanone 1-Propanone, 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)- Neohesperidine Dihydrochalcone (100 mg) 1-Propanone, 1-4-2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-2,6-dihydroxyphenyl-3-(3-hydroxy-4-methoxyphenyl)- 1-(4-((2-o-[6-deoxy-α-l-mannopyranosyl]-β-d-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone Neohesperidin Dihydrochalcone ( NHDC ) BETA-NEOHESPERIDINDIHYDROCHALCONE 1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone Neohesperidin DC neohesperidi dihydrochalcone 1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-prop Neo-DHC Neohesperidin DC(NHDC) neosperidin dihydrochalcone 1-Propanone, 1-[4-[[2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)- Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-a-L-mannopyranosyl)-, b-D- Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-a-L-rhamnopyranosyl- Neohesperidin DHC 1-[4-[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyloxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propane-1-one 1-[4-[2-O-(α-L-Rhamnopyranosyl)-β-D-glucopyranosyloxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone 3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside Neohesperidin DC: HPLC96% Min Neohesperidin dihydrochalcone,1-(4-((2-O-[6-Deoxy-α-L-mannopyranosyl]-β-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone NEDC Neohesperidin dihydrochalcone NEOHESPERIDIN DIHYDROCHALCONE HYDRATE NEOHESPERIDINE DC NEOHESPERIDINE DIHYDROCHALCONE HYDRATE 1-[4-[[2-O-(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)-BETA-D-GLUCOPYRANOSYL]OXY]-2,6-DIHYDROXYPHENYL]-3-(3-HYDROXY-4-METHOXYPHENYL)-1-PROPANONE E-959 beta-d--(6-deoxy-alpha-l-mannopyranosyl) glucopyranoside,3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl-2-o nci-c60764 neohesperidin dihydrochalcone from*citrus fruit Neosperidin Dihydro halcone Neohesperidine hydrate Neohesperidin dihydrochalcone hydrate ,98% NEOHESPERIDIN DIHYDROCHALCONE 85+% Neohesperidin DC: HPLC 1-[4-[[2-O-(6-Deoxy-α-L-Mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-Methoxyphenyl)- Neohesperidin dihydrochalcone, 99%, from Citrus maxima 1-(4-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxyMethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-Methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-Methoxyphenyl)propan-1-one Neohesperidin-dihydrochalcone CRS NeohesperidinDihydrochalconeHydrate> Hesperidin Impurity 4 NHP-DC， NEOHESPERIDIN DIHYDROCHALCONE Neosperidin dihydrochalcone USP/EP/BP Water-Soluble NEOHESPERIDIN DIHYDROCHALCONE(NHDC) 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one New hesperidin dihydrochalcone Happy Sweet Neohesperidin Dihydrochalcone (500 mg) (3,5-Dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(alpha-L-rhamnopyranosyl)-Beta-D-glucopyranoside) Neohesperidin Dihydrochalcone(P) 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one Neohesperidin Dihydrochalcone, 10 mM in DMSO 4-METHOXY-2',3,4',6'-TETRAHYDROXYHYDROCINNAMOPHENONE 4'-BETA-NEOHESPERIDOSIDE