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Naringin dihydrochalcone

Naringin dihydrochalcone Structure
Naringin dihydrochalcone structure
CAS No.
18916-17-1
Chemical Name:
Naringin dihydrochalcone
Synonyms
Naringin DC;Naringine DC;Senior saccharin;Naringin dihydrochal;NARINGINDIHYDROHALCONE;NAGINGINDIHYDROCHALCONE;NARINGIN DIHYDROCHALCONE;NARINGIN DIHYDOROCHALCONE;Naringin dihydrochalcone-RM;ranosyl)- β-D-glucopyranosyl]oxy]-
CBNumber:
CB6140982
Molecular Formula:
C27H34O14
Molecular Weight:
582.56
MDL Number:
MFCD00798060
MOL File:
18916-17-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Naringin dihydrochalcone Properties

Melting point 131-132°C
Boiling point 916.8±65.0 °C(Predicted)
Density 1.63±0.1 g/cm3(Predicted)
vapor pressure 0Pa at 20-50℃
FEMA 4495 | NARINGIN DIHYDROCHALCONE
FLAVIS Number 16.110 | Naringin dihydrochalcone
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in DMSO
form Powder
pka 6.85±0.40(Predicted)
color White to Off-white
JECFA Number 2208
Major Application food and beverages
InChIKey CWBZAESOUBENAP-CUDWAMJSNA-N
SMILES O1[C@H]([C@@H]([C@@H]([C@H]([C@@H]1C)O)O)O)O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO)Oc3cc(c(c(c3)O)C(=O)CCc4ccc(cc4)O)O
LogP -0.703-1.01 at 22.6℃ and pH5-9
CAS DataBase Reference 18916-17-1(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) NARINGIN DIHYDROCHALCONE
FDA UNII 7233QDO0QW
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
WGK Germany  WGK 1
HS Code  29329990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
REACH Registrations Active

Naringin dihydrochalcone price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS003175 naringin dihydrochalcone AldrichCPR 18916-17-1 1G $93.2 2026-04-30 Buy
Cayman Chemical 27791 Naringin Dihydrochalcone ≥98% 18916-17-1 5g $95 2026-04-30 Buy
Cayman Chemical 27791 Naringin Dihydrochalcone ≥98% 18916-17-1 10g $168 2026-04-30 Buy
Cayman Chemical 27791 Naringin Dihydrochalcone ≥98% 18916-17-1 25g $370 2026-04-30 Buy
Cayman Chemical 27791 Naringin Dihydrochalcone ≥98% 18916-17-1 50g $554 2026-04-30 Buy
Product number Packaging Price Buy
CDS003175 1G $93.2 Buy
27791 5g $95 Buy
27791 10g $168 Buy
27791 25g $370 Buy
27791 50g $554 Buy

Naringin dihydrochalcone Chemical Properties,Uses,Production

Description

Naringin dihydrochalcone is an artificial sweetener and flavonoid that has been isolated from various plants and has antioxidant activity. It scavenges ABTS (Item No. 27317), oxygen, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell free assays (IC50s = 24, 322.8, and 318.9 μM, respectively).

Uses

Naringin Dihydrochalcone is an intense sweetener and strong antioxidant compound which displays anti-allegeric activity.

Definition

ChEBI: Naringin dihydrochalcone is a member of flavonoids and a glycoside.

Synthesis

Naringin

10236-47-2

Naringin dihydrochalcone

18916-17-1

Naringin was used as a raw material to synthesize 1-(4-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,6-dihydroxyphenyl)-3-( 4-hydroxyphenyl)propan-1-one was prepared in the following general procedure: 120 g of the natural extract (containing 600 g of 8% naringin) was dissolved in potassium hydroxide solution and filtered to obtain a clarified solution. The filtrate was transferred to a 2000 ml autoclave and 200 g of ethanol and 3 g of palladium carbon catalyst were added. Hydrogen was introduced at 55°C, maintaining the pressure at 1~2MPa, and the reaction was carried out for 5~7 hours until the hydrogen absorption was basically completed. The reaction solution was removed and filtered to remove the palladium-carbon catalyst. Subsequently, the hydrogenated solution was acidified with hydrochloric acid, the pH was adjusted to 5-7, and stirred thoroughly to induce crystallization, and a white solid was rapidly precipitated. The mixture was cooled to 20 °C and filtered, and the resulting wet product was dried under reduced pressure at 60 °C to give 118 g of dihydronaringenin chalcone as a white powder with 98.9% liquid phase purity and 98% molar yield. The product needs to be stored in a cool place under light nitrogen protection.

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References

[1] Patent: CN105801636, 2016, A. Location in patent: Paragraph 0022
[2] Journal of Agricultural and Food Chemistry, 2003, vol. 51, # 11, p. 3309 - 3312

Naringin dihydrochalcone synthesis

10236-47-2
18916-17-1
Synthesis of Naringin dihydrochalcone from Naringin

Naringin dihydrochalcone Preparation Products And Raw materials

Raw materials

Naringin Potassium hydroxide Methanol Palladium Concentrated hydrochloric acid
Hydrogen Ethanol

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Preparation Products

Naringin dihydrochalcone Suppliers

Global( 375)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Wuhan Fortuna Chemical Co., Ltd 027-59207852 13308628970 buy@fortunachem.com China 2699 58
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
ShangHai YuanYe Biotechnology Co., Ltd. 15026964105 shyysw007@163.com China 4998 60
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Adamas Reagent, Ltd. 59
Shandong Xiya Chemical Co., Ltd 57
Sichuan Kulinan Technology Co., Ltd 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Wuhan Fortuna Chemical Co., Ltd 58
Dalian Meilun Biotech Co., Ltd. 58
ShangHai YuanYe Biotechnology Co., Ltd. 60
T&W GROUP 58

View Lastest Price from Naringin dihydrochalcone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Naringin Dihydrochalcone pictures 2026-09-11 Naringin Dihydrochalcone
18916-17-1
 $10.00 1kg 98%HPLC 10000 Changsha Staherb Natural Ingredients Co., Ltd.
Naringin dihydrochalcone pictures 2026-08-25 Naringin dihydrochalcone
18916-17-1
 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
Naringin dihydrochalcone pictures 2026-08-12 Naringin dihydrochalcone
18916-17-1
 $27.00 1KG 99% 10 tons Baoji Guokang Healthchem Co., Ltd.

Naringin dihydrochalcone Spectrum

Naringin dihydrochalcone(18916-17-1)1HNMR

18916-17-1(Naringin dihydrochalcone)Related Search:

Neosperidin dihydrochalcone Naringin trans-Chalcone Naringenin Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers)
NARINGENIN CHALCONE Kaempferol Hesperetin Phloretin Sclareol
Apigenin Phlorizin Prunin Saccharin PONCIRIN
NARINGIN HYDRATE NEOERIOCITRIN Naringin dihydrochalcone

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1-[4-[[2-o-(6-deoxy-l-mannopyranosyl)-d-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone NARINGIN DIHYDROCHALCONE NAGINGINDIHYDROCHALCONE NARINGINDIHYDROHALCONE NARINGIN DIHYDOROCHALCONE 1-Propanone,1-[4-[[2-O-(6-deoxy-α-L-mannopy 2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)- ranosyl)- β-D-glucopyranosyl]oxy]- Senior saccharin Naringin dihydrochalcone 18916-17-1 1-[4-[[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyl-2-oxanyl)oxy]-2-oxanyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone Naringin dihydrochal Naringin Dihydrochalcone(Naringin DC) 1-Propanone, 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)- Naringin dihydrochalcone USP/EP/BP 99% purity Naringin dihydrochalcone 1-[4-[(3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one 1-(4-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one (naringin-dihydrochalcone) Naringine DC Naringin dihydrochalcone-RM 3,5-dihydroxy-4-[3-(4-hydroxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-α-Dmannopyranosyl)-β-D-gulopyranoside Naringin dihydrochalcone, 10 mM in DMSO Neohesperidin dihydrochalcone EP Impurity D (Naringin dihydrochalcone) Abmole M3920-100mg Naringin dihydrochalcone 18916-17-1 Naringin DC 18916-17-1 18915-17-1 C27H34O14 C27H32O142HCl Inhibitors reagent standard substance CITRIMORE Flavanones Natural Plant Extract