2-Bromo-5-chloropyrazine
- CAS No.
- 912773-21-8
- Chemical Name:
- 2-Bromo-5-chloropyrazine
- Synonyms
- 2-BROMO-5-CHLOROPYRAZINE;2-Bromo-5-chloropyrazin;2-Chloro-5-bromopyrazine;5-BROMO-2-CHLOROPYRAZINE;Pyrazine, 2-bromo-5-chloro-;2-Bromo-5-chloro-1,4-diazine;5-BROMO-2-CHLOROPYRAZINE ISO 9001：2015 REACH
- CBNumber:
- CB3220449
- Molecular Formula:
- C4H2BrClN2
- Molecular Weight:
- 193.43
- MDL Number:
- MFCD08460074
- MOL File:
- 912773-21-8.mol
- TDS File:
- TDS
| Boiling point | 208℃ |
|---|---|
| Density | 1.859 |
| Flash point | 80℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -4.53±0.10(Predicted) |
| Appearance | Colorless to off-white Solid-Liquid Mixture |
| InChI | InChI=1S/C4H2BrClN2/c5-3-1-8-4(6)2-7-3/h1-2H |
| InChIKey | UXCPLGLOAZWCKO-UHFFFAOYSA-N |
| SMILES | C1(Br)=NC=C(Cl)N=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P271-P280-P261 |
| HS Code | 2933998090 |
2-Bromo-5-chloropyrazine price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR60106 | 2-Bromo-5-chloropyrazine >97% | 912773-21-8 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR60106 | 2-Bromo-5-chloropyrazine >97% | 912773-21-8 | 25g | $101 | 2026-06-04 | Buy |
| Activate Scientific | AS50757 | 2-Bromo-5-chloropyrazine 97% | 912773-21-8 | 5g | $30 | 2026-06-04 | Buy |
| Apolloscientific | OR60106 | 2-Bromo-5-chloropyrazine >97% | 912773-21-8 | 100g | $394 | 2026-06-04 | Buy |
| Activate Scientific | AS50757 | 2-Bromo-5-chloropyrazine 97% | 912773-21-8 | 25g | $111 | 2026-06-04 | Buy |
2-Bromo-5-chloropyrazine Chemical Properties, Uses, Production
Chemical Properties
White to light yellow crystal or liquid
Uses
2-Bromo-5-chloropyrazine is an intermediate of favipiravir. Favipiravir is a selective inhibitor of the RNA-dependent RNA polymerase of influenza viruses. This drug is a broad-spectrum antiviral agent. It is indicated for the treatment of seasonal influenza, H1N1, Ebola and other diseases.
Preparation
2-Bromo-5-chloropyrazine is synthesised by first reacting dibromoheine with 2-aminopyrazine to yield 2-amino-5-bromopyrazine. The 2-amino-5-bromopyrazine is then dissolved in DCM, and titanium(IV) chloride and tert-butyl nitrite are added to complete the reaction. The reaction process consists of two steps, as follows:
Step 1: Formation of 2-amino-5-bromopyrazine
Under stirring conditions in an ice-salt bath and a nitrogen atmosphere, an acetonitrile solution of dibromoheine was added dropwise to an acetonitrile solution of 2-aminopyrazine. Upon completion of the addition, the mixture was stirred at 0–5 °C. Thin-layer chromatography confirmed the absence of 2-aminopyrazine in the reaction system, The reaction is complete; the reaction is then quenched. The reaction mixture is concentrated to remove acetonitrile, followed by extraction. The organic phase is collected, the solvent is removed, and the organic phase is dried. Recrystallisation is then carried out to yield 2-amino-5-bromopyrazine;
Step 2: Preparation of 2-bromo-5-chloropyrazine
Dissolve the 2-amino-5-bromopyrazine obtained in Step (1) in DCM, then add titanium(IV) chloride and stir to mix at 0 °C. Subsequently, add tert-butyl nitrite dropwise to the reaction mixture, stir for 20–30 minutes, then raise the temperature to room temperature and continue stirring for 8–12 hours. Upon completion of the reaction, quench the reaction. Allow the reaction mixture to stand until separation occurs, then separate the organic phase. Extract the aqueous phase with dichloromethane. Combine the organic phases, wash with saturated brine and dry. Purify the dried organic phase by removing the solvent to afford the target product, 2-bromo-5-chloropyrazine.
2-Bromo-5-chloropyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Youmede Technology Co., LTD | 18964944463 | 56810034@qq.com | China | 40 | 58 |
| Suzhou Xinkai Bio-Medical Technology Co., Ltd. | 0512-67213637 13952409868 | peter19zhang@163.com | China | 442 | 55 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Kohn & Shawn Pharmatech Co.,Ltd | 0943-8293106 | sales@kyxpharma.com | China | 297 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 724 | 60 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 28-83379370 13880556291 | tcy@tcypharm.com | China | 509 | 57 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 2-Bromo-5-chloropyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-BROMO-2-CHLOROPYRAZINE
912773-21-8
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-04-30 | 2-Bromo-5-chloropyrazine
912773-21-8
|
1KG | 99.0%+ | 800 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | 5-BROMO-2-CHLOROPYRAZINE
912773-21-8
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 5-BROMO-2-CHLOROPYRAZINE
912773-21-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Bromo-5-chloropyrazine
912773-21-8
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-BROMO-2-CHLOROPYRAZINE
912773-21-8
- $1.00
- 99%
- Career Henan Chemical Co
