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3-Chloropyrazine-2-carbonitrile

3-Chloropyrazine-2-carbonitrile Structure
3-Chloropyrazine-2-carbonitrile structure
CAS No.
55557-52-3
Chemical Name:
3-Chloropyrazine-2-carbonitrile
Synonyms
BUTTPARK 29\04-93;Favipiravir Impurity2;Favipiravir Impurity16;Favipiravir Impurity 32;2-CHLORO-3-CYANOPYRAZINE;3-Chloro-2-cyanopyrazine;2-Chloro-3-cyannopyrazine;oropyrazine-2-carbonitriL;3-Chloropyrazine-2-carbon...;3-Chlorpyrazin-2-carbonitril
CBNumber:
CB1105450
Molecular Formula:
C5H2ClN3
Molecular Weight:
139.54
MDL Number:
MFCD00219653
MOL File:
55557-52-3.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:52
Product description Number Pack Size Price
3-Chloropyrazine-2-carbonitrile C381220 100g $470
3-Chloropyrazine-2-carbonitrile 99.17% CS-W001897 500g $476
2-Chloro-3-cyanopyrazine FC32822 250g $800
3-CHLOROPYRAZINE-2-CARBONITRILE 95.00% HCH0418999 5G $975.98
3-CHLOROPYRAZINE-2-CARBONITRILE 95.00% HCH0418999 1G $166.95
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3-Chloropyrazine-2-carbonitrile Properties

Melting point 45-47°C
Boiling point 264.1±35.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form solid
pka -5.41±0.10(Predicted)
color Light brown to black
InChI InChI=1S/C5H2ClN3/c6-5-4(3-7)8-1-2-9-5/h1-2H
InChIKey SDLFAEGTVBPHBK-UHFFFAOYSA-N
SMILES C1(C#N)=NC=CN=C1Cl
CAS DataBase Reference 55557-52-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P260-P280-P301+P310-P304+P340-P305+P351+P338-P312
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38-41-37/38-22
Safety Statements  26-36/37/39-39
RIDADR  3276
Hazard Note  Harmful
HS Code  2933998090

3-Chloropyrazine-2-carbonitrile price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C381220 3-Chloropyrazine-2-carbonitrile 55557-52-3 100g $470 2021-12-16 Buy
ChemScene CS-W001897 3-Chloropyrazine-2-carbonitrile 99.17% 55557-52-3 500g $476 2021-12-16 Buy
Biosynth Carbosynth FC32822 2-Chloro-3-cyanopyrazine 55557-52-3 250g $800 2021-12-16 Buy
American Custom Chemicals Corporation HCH0418999 3-CHLOROPYRAZINE-2-CARBONITRILE 95.00% 55557-52-3 5G $975.98 2021-12-16 Buy
American Custom Chemicals Corporation HCH0418999 3-CHLOROPYRAZINE-2-CARBONITRILE 95.00% 55557-52-3 1G $166.95 2021-12-16 Buy
Product number Packaging Price Buy
C381220 100g $470 Buy
CS-W001897 500g $476 Buy
FC32822 250g $800 Buy
HCH0418999 5G $975.98 Buy
HCH0418999 1G $166.95 Buy

3-Chloropyrazine-2-carbonitrile Chemical Properties,Uses,Production

Uses

3-Chloropyrazine-2-carbonitrile is a reactant in the syntheses of tuberculostatic pyrazine derivatives.

Synthesis

Pyrazinecarbonitrile

19847-12-2

3-Chloropyrazine-2-carbonitrile

55557-52-3

General procedure for the synthesis of 2-chloro-3-cyanopyrazine from 2-cyanopyrazine: sulfonyl chloride (21.2 mL, 260.8 mmol) was slowly added to a solution of pyrazine-2-carbonitrile (6.90 g, 65.65 mmol) in toluene (48 mL) and DMF (5 mL) over 10 minutes. The reaction mixture was stirred in an ice bath for 30 minutes, followed by gradual warming to room temperature and continued stirring for 5 hours. After completion of the reaction, the toluene layer was decanted and the residual slightly reddish oily material was extracted three times with ether. The toluene and ether layers were combined, quenched with ice water and cooled in an ice bath. Subsequently, the combined organic layers were neutralized with solid NaHCO3, separated and the aqueous layer was further extracted with ether. All organic layers were combined, washed with water, dried over anhydrous Na2SO4, filtered and the solvent evaporated under reduced pressure to give the crude product 2-chloro-3-cyanopyrazine. The crude product was purified by silica gel column chromatography (eluent: 100% dichloromethane) to afford 3-chloropyrazine-2-carbonitrile (4.7 g, 51% yield) as a white powder. The product characterization data were as follows: Rf = 0.76 (dichloromethane); melting point 44-46 °C (literature value: 47-48 °C); IR (KBr) νmax (cm-1): 3088 (νCHar), 2242 (νCN), 1377 (νC=C), 1087 (νC-N); 1H NMR (400 MHz, DMSO-d6): δ 8.91 (d, 1H, J = 2.4 Hz, H-6), 8.88 (d, 1H, J = 2.4 Hz, H-5); 13C NMR (100 MHz, DMSO-d6): δ 150.67 (C-3), 147.97 (C-5), 144.26 (C-6), 129.87 (C-2), 114.66 (CN); MS (ESI) m/z (%): 140.3 (100) [M + H]+, 142.3 (40) [M + H + 2]+. Elemental analysis (C5H2ClN3) Calculated values: C, 43.04; H, 1.44; N, 30.11. Measured values: C, 43.18; H, 1.45; N, 30.16.

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 171 - 183
[2] Patent: EP1582521, 2005, A1. Location in patent: Page/Page column 133-134
[3] Magnetic Resonance in Chemistry, 2009, vol. 47, # 7, p. 617 - 624

3-Chloropyrazine-2-carbonitrile synthesis

55321-99-8
55557-52-3
Synthesis of 3-Chloropyrazine-2-carbonitrile from 3-HYDROXYPYRAZINE-2-CARBOXAMIDE

3-Chloropyrazine-2-carbonitrile Preparation Products And Raw materials

Raw materials

dimethyldioxirane Trimethylsilyl cyanide Acetonitrile Acetone Zinc chloride
2-Chloropyrazine 4-(3-Chloropyrazin-2-yl)-2-Methylbut-3-yn-2-ol Triethanolamine 3-HYDROXYPYRAZINE-2-CARBOXAMIDE 3-chloro-1-oxido-pyrazine
3-pyrazinecarboxaMide 1-oxide

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Preparation Products

Pyrazinecarbonitrile, 6-amino- (9CI) METHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE 2-AMINOMETHYL-3-CHLOROPYRAZINE 3-AMINOPYRAZINE-2-CARBONITRILE (3-Chloropyrazin-2-yl)MethanaMine hydrochloride
6-chloropyrazine-2-carbonitrile 1H-Pyrazolo[3,4-b]pyrazin-3-amine,1-methyl-(9CI)

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3-Chloropyrazine-2-carbonitrile Suppliers

Global( 287)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20138 58
Moxin Chemicals 		+86-17320513646 +8617320513646 anna@molcoo.com China 10000 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13494 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29847 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2954 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Moxin Chemicals 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
ATK CHEMICAL COMPANY LIMITED 		60
AB PharmaTech,LLC 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Finer Chemical Co., Ltd 		58

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View Lastest Price from 3-Chloropyrazine-2-carbonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloropyrazine-2-carbonitrile pictures 2025-11-18 3-Chloropyrazine-2-carbonitrile
55557-52-3
 US $1.10 / g 1g 99.00% 100 Tons Dideu Industries Group Limited
3-Chloropyrazine-2-carbonitrile pictures 2025-09-25 3-Chloropyrazine-2-carbonitrile
55557-52-3
 US $5.00-0.10 / KG 1KG 98% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
Favipiravir Impurity pictures 2025-07-31 Favipiravir Impurity
55557-52-3
 US $0.00-0.00 / mg 10mg 98 10000000 Moxin Chemicals

3-Chloropyrazine-2-carbonitrile Spectrum

3-Chloropyrazine-2-carbonitrile(55557-52-3)1HNMR

55557-52-3(3-Chloropyrazine-2-carbonitrile)Related Search:

Sulfachoropyrazine sodium N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO 3-OXO-3,4-DIHYDROPYRAZINE-2-CARBONITRILE 2-Chloro-3-cyanopyridine Hydrochlorothiazide
Pyrazinamide Glipizide Pyrazinecarboxamide, 3,6-difluoro- (9CI) 6-Bromo-3-chloropyrazine-2-carbonitrile Methyl 6-bromo-3-oxo-3,4-dihydropyrazine-2-carboxylate
3-HYDROXYPYRAZINE-2-CARBOXAMIDE 2-Pyrazinecarbonitrile, 3-fluoro- 3,6-DibroMopyrazine-2-carbonitrile Pyrazinecarboxamide, 5-fluoro-3,4-dihydro-3-oxo- (9CI) Pyrazinecarboxamide, 6-fluoro- (9CI)
Difluorochloromethane 3-AMINO-5-CHLOROPYRAZINE-2-CARBONITRILE 5-CHLOROPYRAZINE-2-CARBONITRILE

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3-Chloro-2-cyanopyrazine 3-Chloropyrazine-2-carbonitrile, 95+% 2-Chloro-3-cyanopyrazine 95%+ 3-chloropyrazin-2-carbonitrile BUTTPARK 29\04-93 3-CHLOROPYRAZINE-2-CARBONITRILE 2-CHLORO-3-CYANOPYRAZINE 3-CHLOROPYAZINE-2-CARBONITRILE 3-Chloro-2-pyrazinecarbonitrile C5H2ClN3 Substance Availability 2-chloro-3-cyanopyrazine 2-Chloro-3-cyannopyrazine 3-Chloropyrazine-2-carbon... 2-Chloro-3-cyanopyrazine, 2-Chloro-3-cyano-1,4-diazine Favipiravir Impurity16 Favipiravir Impurity2 oropyrazine-2-carbonitriL 2-Pyrazinecarbonitrile, 3-chloro- Favipiravir Impurity 32 3-Chloropyrazine-2-carbonitrile ISO 9001：2015 REACH AMPZ00203-CHLORO-2-PYRAZINECARBONITRILE 3-Chlorpyrazin-2-carbonitril 55557-52-3 C5H2ClN3 Pyrazines, Pyrimidines & Pyridazines Intermediates Pyrazine pharmacetical Pyrazines, Pyrimidines & Pyridazines Pyridazine series