1-Bromo-2-naphthaldehyde
- CAS No.
- 3378-82-3
- Chemical Name:
- 1-Bromo-2-naphthaldehyde
- Synonyms
- 1-Bromo-2-naphthal;1-broMo-2-phthaldehyde;1-Bromo-2-naphthaldehyde;1-Bromo-2-naphthaldehyde >1-BROMO-2-NAPHTHALDEHYDE 96+%;1-Bromo-2-naphthalenecarbaldehyde;1-BROMONAPHTHALENE-2-CARBALDEHYDE;1-Bromo-2-naphthalenecarboxaldehyde;1-bromo-2-naphthaldehyde crystalline;2-Naphthalenecarboxaldehyde, 1-bromo-
- CBNumber:
- CB3225530
- Molecular Formula:
- C11H7BrO
- Molecular Weight:
- 235.08
- MDL Number:
- MFCD00046368
- MOL File:
- 3378-82-3.mol
- MSDS File:
- SDS
| Melting point | 118°C |
|---|---|
| Boiling point | 347℃ |
| Density | 1.552 |
| Flash point | 120℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | crystals |
| Appearance | Off-white to yellow Solid |
| BRN | 2613639 |
| InChI | InChI=1S/C11H7BrO/c12-11-9(7-13)6-5-8-3-1-2-4-10(8)11/h1-7H |
| InChIKey | CYGUXEZVBLMVRV-UHFFFAOYSA-N |
| SMILES | C1(Br)=C2C(C=CC=C2)=CC=C1C=O |
| CAS DataBase Reference | 3378-82-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29130000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1-Bromo-2-naphthaldehyde price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 779636 | 1-Bromo-2-naphthaldehyde ≥96.0% (HPLC) | 3378-82-3 | 1g | $157 | 2026-04-30 | Buy |
| TCI Chemical | B1647 | 1-Bromo-2-naphthaldehyde >96.0%(GC) | 3378-82-3 | 1g | $75 | 2026-04-30 | Buy |
| TCI Chemical | B1647 | 1-Bromo-2-naphthaldehyde >96.0%(GC) | 3378-82-3 | 5g | $223 | 2026-04-30 | Buy |
| TRC | TRC-B688455-250MG | 1-Bromo-2-naphthaldehyde | 3378-82-3 | 250mg | $78 | 2026-06-03 | Buy |
| TRC | TRC-B688455-2.5G | 1-Bromo-2-naphthaldehyde | 3378-82-3 | 2.5g | $249 | 2026-06-03 | Buy |
1-Bromo-2-naphthaldehyde Chemical Properties, Uses, Production
Chemical Properties
Light yellow solid
Uses
1-Bromo-2-naphthaldehyde is used as a reagent in the synthesis of Hoveyda-Grubbs type metathesis catalysts which are used in cross olefin metathesis. 1-Bromo-2-naphthaldehyde is also used in the preparation of novel (-)-cercosporamide derivatives as potent selective PPARγ modulators.
Synthesis Reference(s)
The Journal of Organic Chemistry, 46, p. 4617, 1981 DOI: 10.1021/jo00335a076
Synthesis
37763-43-2
3378-82-3
General procedure for the synthesis of 1-bromo-2-naphthalene formaldehyde from 1-bromo-2-(bromomethyl)naphthalene: In a 2L reactor, 4-methylmorpholine N-oxide (61.4 g, 524 mmol), molecular sieves (200 g) and acetonitrile (1.2 L) were added and stirred for 30 min at 0 °C under nitrogen protection. Subsequently, 1-bromo-2-(bromomethyl)naphthalene (78 g, 262 mmol) was added and stirring was continued for 6 hours at room temperature. After completion of the reaction, the reaction mixture was filtered and the filtrate was washed with dichloromethane. The filtrate was concentrated and purified by column chromatography to afford 1-bromo-2-naphthaldehyde (45 g) in 73% yield.
References
[1] European Journal of Organic Chemistry, 2012, # 31, p. 6155 - 6164,10
[2] European Journal of Organic Chemistry, 2012, # 31, p. 6155 - 6164
[3] Tetrahedron Letters, 1994, vol. 35, # 48, p. 8985 - 8988
[4] Patent: US2018/72753, 2018, A1. Location in patent: Paragraph 0163-0164
[5] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 9, p. 1363 - 1378
1-Bromo-2-naphthaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Changkuan Technology Co., Ltd | 0371-63769919 18530983798 | sales5@changkuantech.com | China | 158 | 55 |
| Zhengzhou Ruijia Pharmaceutical Technology Co. LTD | 0371-037161101779 15737143979 | 652371024@qq.com | China | 102 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from 1-Bromo-2-naphthaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-19 | 1-BROMO-2-NAPHTHALDEHYDE
3378-82-3
|
1KG | 99% | 1000 KG | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-02-02 | 1-Bromo-2-naphthaldehyde
3378-82-3
|
10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | 1-BROMO-2-NAPHTHALDEHYDE
3378-82-3
|
$2.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 1-BROMO-2-NAPHTHALDEHYDE
3378-82-3
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-Bromo-2-naphthaldehyde
3378-82-3
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 1-BROMO-2-NAPHTHALDEHYDE
3378-82-3
- $2.00
- 99%
- Career Henan Chemical Co
