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N-Boc-L-tert-Leucine

N-Boc-L-tert-Leucine Structure
N-Boc-L-tert-Leucine structure
CAS No.
62965-35-9
Chemical Name:
N-Boc-L-tert-Leucine
Synonyms
BOC-L-TERT-LEUCINE;BOC-TLE-OH;N-(TERT-BUTOXYCARBONYL)-L-TERT-LEUCINE;BOC-TLE;BOC-L-TLE-OH;BOC-L-ALPHA-T-BUTYLGLYCINE;N-Boc-L-tert-leucine,99%e.e.;N-(METHOXYCARBONYL)-L-TERT-LEUCINE;Boc-Tle-OH-d9;BOC-TBU-GLY-OH
CBNumber:
CB3225606
Molecular Formula:
C11H21NO4
Molecular Weight:
231.29
MDL Number:
MFCD00065574
MOL File:
62965-35-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:03:32
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N-Boc-L-tert-Leucine Properties

Melting point 118-121 °C
alpha -4.2 º (c=1% in glacial acetic acid)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Crystalline Powder
color White to slightly yellow
optical activity [α]20/D 4.2±0.5°, c = 1% in glacial acetic acid
BRN 1962763
Major Application peptide synthesis
InChI InChI=1/C11H21NO4/c1-10(2,3)7(8(13)14)12-9(15)16-11(4,5)6/h7H,1-6H3,(H,12,15)(H,13,14)/t7-/s3
InChIKey LRFZIPCTFBPFLX-SSDOTTSWSA-N
SMILES [C@@H](C(=O)O)(C(C)(C)C)NC(=O)OC(C)(C)C |&1:0,r|
CAS DataBase Reference 62965-35-9(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314-H290
Precautionary statements  P501-P260-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  24/25
WGK Germany  3
HS Code  2924 19 00
HazardClass  IRRITANT
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
0 0

N-Boc-L-tert-Leucine price More Price(96)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 15451 Boc-Tle-OH ≥99.0% (T) 62965-35-9 5G $91.4 2026-04-30 Buy
Sigma-Aldrich 8.53068 Boc-L-α-t-butylglycine Novabiochem? 62965-35-9 5G $839 2026-04-30 Buy
Sigma-Aldrich 15451 Boc-Tle-OH ≥99.0% (T) 62965-35-9 25g $333 2026-04-30 Buy
TCI Chemical B3754 N-(tert-Butoxycarbonyl)-L-tert-leucine >98.0%(HPLC)(T) 62965-35-9 5g $58 2026-04-30 Buy
TCI Chemical B3754 N-(tert-Butoxycarbonyl)-L-tert-leucine >98.0%(HPLC)(T) 62965-35-9 25g $203 2026-04-30 Buy
Product number Packaging Price Buy
15451 5G $91.4 Buy
8.53068 5G $839 Buy
15451 25g $333 Buy
B3754 5g $58 Buy
B3754 25g $203 Buy

N-Boc-L-tert-Leucine Chemical Properties, Uses, Production

Description

N-Boc-L-tert-Leucine is a white to slightly yellow crystalline powder. The carboxyl group in its structure can be condensed with alcohol compounds under the catalysis of acid or base to obtain the corresponding ester derivatives. This substance can be used for the synthesis of amino acid drugs due to the various chemical transformation properties of its amine and carboxyl groups. The Boc protective group is able to protect the amino group of the amino acid from non-specific reactions with other reactants. This compound is a derivative of L-tert-Leucine, which is a non-polar amino acid. Its tert-butyl group exhibits significant hydrophobicity and steric hindrance, enabling effective control of molecular conformation in chemical reactions, leading to the formation of chiral compounds. As a crucial chiral intermediate, L-tert-leucine is widely employed in the synthesis of anti-cancer, anti-viral, and biological inhibitors. Additionally, L-tert-leucine serves as an essential additive in the food and cosmetic industry.

Chemical Properties

White crystalline powder

Uses

Atazanavir Related Compound A

Application

N-Boc-L-tert-Leucine was used as a precursor in the synthesis of a precatalyst.

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

Synthesis

L-tert-Leucine

20859-02-3

Di-tert-butyl dicarbonate

24424-99-5

N-Boc-L-tert-Leucine

62965-35-9

Step A: Synthesis of N-Boc-L-tert-Leucine 1. add triethylamine (56mL, 0.4mol) to a methanol (150mL) suspension of L-tert-leucine (26.1g, 0.2mol) at 0°C. 2. slowly add di-tert-butyl dicarbonate (48g, 0.22mol) to a methanol (40mL) solution of N-Boc-L-tert-leucine. 2. a solution of di-tert-butyl dicarbonate (48 g, 0.22 mol) in methanol (40 mL) was added slowly to the above mixture, controlling the reaction temperature between 0 and 5°C. 3. The reaction mixture was stirred at room temperature overnight. 4. Upon completion of the reaction, the solvent was removed under vacuum. 5. The residue was dissolved in ethyl acetate (200 mL) and the organic layer was washed with 10% w/v aqueous citric acid (3 x 100 mL). 6. The organic layer was dried with anhydrous magnesium sulfate, filtered and the solvent was removed in vacuum to afford N-Boc-L-tert-leucine as a light yellow oil (48.9 g, yield >100% with residual solvent). Product characterization: 1H NMR (CDCl3): δ/ppm 9.20 (1H, bs, NH), 5.10 (1H, m, CH), 4.15 (1H, m, CH), 1.45 (9H, s, tert-butyl in Boc), 1.00 (9H, s, tert-butyl in tert-leucine).

References

[1] Patent: US6716878,  2004,  B1. Location in patent: Page column 14
[2] Patent: US6716878,  2004,  B1. Location in patent: Page column 62
[3] Patent: CN107325025,  2017,  A. Location in patent: Paragraph 0086; 0087
[4] Patent: WO2005/73195,  2005,  A2. Location in patent: Page/Page column 96-97
[5] Tetrahedron,  2008,  vol. 64,  # 18,  p. 3980 - 3997
[6] Ghosh, D., Sadhukhan, A., Maity, N., Abdi, S., ul Noor-H. Khan, Kureshy, R., &amp; Bajaj, H. C. (2014). Oxazoline Derivatives Tagged with Tosylated Amino Acids as Recyclable Organocatalysts for Enantioselective Allylation of Aldehydes. <i>ChemInform</i>, <i>80 5 1</i>. https://doi.org/10.1002/CHIN.201446078

N-Boc-L-tert-Leucine synthesis

20859-02-3
24424-99-5
62965-35-9
Synthesis of N-Boc-L-tert-Leucine from L-tert-Leucine and Di-tert-butyl dicarbonate

N-Boc-L-tert-Leucine Preparation Products And Raw materials

Raw materials

L-tert-Leucine (S)-N-Boc-tert-leucinol 98 Di-tert-butyl dicarbonate Triethylamine Methanol

Preparation Products

methyl (2S)-2-amino-3,3-dimethylbutanoate Methoxycarbonyl-L-tert-leucine Asunaprevir (S)-tert-butyl (3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)carbamate(WXC08256) L-tert-Leucine methyl ester hydrochloride
(S)-benzyl 2-amino-3,3-dimethylbutanoate(WXG02404) L-tert-Leucine

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N-Boc-L-tert-Leucine Suppliers

Global Suppliers ( 483)
Supplier Tel Email Country ProdList Advantage
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Anhui Dexinjia Biopharm Co., Ltd 0531-82375893 15553111391 phoebe@jndxj.com China 285 58
Shanghai Chiral Chemicals Inc. 021-37285021 13472570865 tym7xi@aliyun.com China 299 64
Changzhou Huihan Biotechnology Co., Ltd. 15380463325 15380463325 819573646@qq.com China 73 55
Shanxi Nuocheng Biotechnology Co., Ltd 17835231871 572710841@qq.com China 7939 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemvon Biotechnology Co., Ltd 021-50790412 info@chemvon.com China 371 57
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Shanghai Hanhong Scientific Co.,Ltd. 64
Anhui Dexinjia Biopharm Co., Ltd 58
Shanghai Chiral Chemicals Inc. 64
Changzhou Huihan Biotechnology Co., Ltd. 55
Shanxi Nuocheng Biotechnology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Chemvon Biotechnology Co., Ltd 57
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81

View Latest Price from N-Boc-L-tert-Leucine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Boc-L-tert-Leucine pictures 2026-09-18 N-Boc-L-tert-Leucine
62965-35-9
 1KG 98%min 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
N-Boc-L-tert-Leucine pictures 2026-08-25 N-Boc-L-tert-Leucine
62965-35-9
 $65.00-650.00 1KG 0.99 20 tons Zibo Hangyu Biotechnology Development Co., Ltd
N-Boc-L-tert-Leucine pictures 2026-07-30 N-Boc-L-tert-Leucine
62965-35-9
 $100.00-2000.00 1kg 99% 10MT per month Anhui Dexinjia Biopharm Co., Ltd

N-Boc-L-tert-Leucine Spectrum

N-Boc-L-tert-Leucine(62965-35-9)1HNMR

62965-35-9 (N-Boc-L-tert-Leucine) Related Search:

Boc-L-norleucine 6-Aminocaproic acid 3-Aminophenol N-Carbobenzyloxyglycine Aminoethoxyvinyl glycine hydrochloride
tert-Butanol Glycine L-tert-Leucine Tris(hydroxymethyl)aminomethane N-Boc-L-alaninol
BOC-L-Prolinol N-Boc-L-Phenylalaninol N-Carbobenzoxy-DL-leucine Methoxycarbonyl-L-tert-leucine (2S,4R)-N-Boc-4-hydroxy-3,3-dimethylpyrrolidine-2-carboxylic acid
(S)-N-Boc-3,3-dimethylpyrrolidine-2-carboxylic acid Boc-D-alpha-t-butylglycine (S)-Boc-1-adamantyl-glycine

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BOC-TBU-GLYCINE BOC-TBU-GLY-OH BOC-TLE BOC-ALPHA-BUTYLGLYCINE BOC-ALPHA-T-BUTYLGLYCINE BOC-ALPHA-T-BUTYLGLYCINE-OH BOC-ALPHA-T-BUTYL-GLY-OH BOC-L-T-BUTYLGLYCINE BOC-L-ALPHA-T-BUTYLGLYCINE RARECHEM EM WB 0082 (S)-N-(TERT-BUTOXYCARBONYL)-TERT-LEUCINE (S)-N-BOC-2-AMINO-3,3-DIMETHYLBUTYRIC ACID N-ALPHA-TERT-BUTYLOXYCARBONYL-L-TERT-BUTYLGLYCINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-T-LEUCINE N-ALPHA-T-BUTOXYCARBONYL-L-ALPHA-T-BUTYL-GLYCINE N-ALPHA-T-BUTOXYCARBONYL-L-T-BUTYLGLYCINE N-ALPHA-T-BUTOXYCARBONYL-L-T-LEUCINE N-ALPHA-T-BUTYLOXYCARBONYL-L-T-LEUCINE N-ALPHA-T-BUTOXYCARBONYL-(S)-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID N-ALPHA-T-BOC-L-T-LEUCINE N-ALPHA-T-BOC-L-ALPHA-T-BUTYL-GLYCINE N-BOC-(L)-T-LEUCINE N-BOC-L-TERT-LEUCINE N-(TERT-BUTOXYCARBONYL)-L-TERT-LEUCINE N-(METHOXYCARBONYL)-L-TERT-LEUCINE L-Valine, N-(1,1-dimethylethoxy)carbonyl-3-methyl- BOC-L-T-LEUCINE Boc-L-α-tert-butylglycine≥ 98% (HPLC) Boc-L-α-tert-butyl-Gly-OH N-Boc-L-tert-leucine,99%e.e. Boc-L-α-t-butylglycine Novabiochem (Tert-Butoxy)Carbonyl Tle-OH Boc-Tle-OH-d9 BOC-L-2-AMINO-3,3-DIMETHYLBUTANOIC ACID N-alpha-t-Butyloxycarbonyl-L-t-leucine, N-alpha-t-Butyloxycarbonyl-L-t-butylglycine Boc--t-Butylglycine (S)-2-(tert-butoxycarbonyl)-3,3-dimethylbutanoic a BOC-L-TERT-BUTYLGLYCINE (S)-N-Boc-2-amino-3,3-dimethylbutyric acid, Boc-L-tert-leucine Boc-a-tert-Butyl-Gly-OH N-BOC-L-tert-Leucine,98% N-BOC-L-tert-LeucineN-(tert-Butoxycarbonyl)-L-leucine Boc-Tle-OH (Boc-tertleucine) N-BOC-L-tert-Leucine, 98% 5GR (2S)-2-(tert-ButoxycarbonylaMino)-3,3-diMethylbutanoic Acid (S)-2-(((tert-Butoxy)carbonyl)aMino)-3,3-diMethylbutanoic Acid (S)-2-tert-ButoxycarbonylaMino-3,3-diMethylbutyric Acid N-tert-Butoxyc (S)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutyric Acid (S)-2-(Boc-amino)-3,3-dimethylbutyric Acid N-Boc-L-tert-leucine Boc-Tle-OH BOC-L-tert-Leucine,Boc-Alpha-ButylGlycine N-(tert-Butoxycarbonyl)-L-tert-leucine > Boc-Tle-OH Boc-?-tert-butyl-Gly-OH (S)-2-(Boc-amino)-3,3-dimethylbutyric Acid N-Boc-L-tert-Leucine USP/EP/BP Boc-L-α-tert-butylglycine Tert butoxycarbonyl-l-tert leucine (2S)-3,3-dimethyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid BOC-Tert-leu-OH