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4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol

CAS No.
40951-69-7
Chemical Name:
4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol
Synonyms
Taxiresinol;4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol;1,2-Benzenediol, 4-[(2S,3R,4R)-tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)-2-furanyl]-
CBNumber:
CB32277524
Molecular Formula:
C19H22O6
Molecular Weight:
346.37
MDL Number:
MFCD06794931
MOL File:
40951-69-7.mol
Last updated:2025-04-18 09:52:05

4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol Properties

Melting point 157-158 °C(Solv: methanol (67-56-1))
Boiling point 590.3±50.0 °C(Predicted)
Density 1.331±0.06 g/cm3(Predicted)
pka 9.60±0.10(Predicted)

4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0013730 (+)-TAXIRESINOL 95.00% 40951-69-7 5MG $501.31 2021-12-16 Buy
Arctom CFN97744 Taxiresinol 40951-69-7 5mg $463 2021-12-16 Buy
Product number Packaging Price Buy
API0013730 5MG $501.31 Buy
CFN97744 5mg $463 Buy

4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol Chemical Properties,Uses,Production

Uses

Taxiresinol is an orally active and potent lignan, that can be isolated from the heartwood of Taxus baccata. Taxiresinol shows significant antinociceptive activity[1].

in vivo

Taxiresinol (100 mg/kg, oral administration, once) shows significant antinociceptive activity against p-benzoquinone-induced abdominal contractions in mice[1].

Animal Model:Male Swiss albino mice (20-25 g)[1]
Dosage:100 mg/kg
Administration:Oral administration, sixty minutes after the oral administration of test sample, the mice were intraperitoneally injected with 0.1 ml/10 g body weight of 2.5% (v/v) p-benzoquinone solution in distilled H2O.
Result:Showed significant antinociceptive activity against p-benzoquinone-induced abdominal contractions (writhing movements) in mice, with a inhibitory ratio of 37.8%.

References

[1] Küpeli E, et al. Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. J Ethnopharmacol. 2003 Dec;89(2-3):265-70. DOI:10.1071/bi9760365

4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol Preparation Products And Raw materials

Raw materials

Preparation Products

4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol Suppliers

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4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol Taxiresinol 1,2-Benzenediol, 4-[(2S,3R,4R)-tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)-2-furanyl]- 40951-69-7