Asulam
- CAS No.
- 3337-71-1
- Chemical Name:
- Asulam
- Synonyms
- asulox;ASULAM;ASILAN;Asulon;plakin;Jonnix;Arulam;Asilam;asulan;ASULUM
- CBNumber:
- CB3244887
- Molecular Formula:
- C8H10N2O4S
- Molecular Weight:
- 230.24
- MDL Number:
- MFCD00055534
- MOL File:
- 3337-71-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 142-144°C (dec.) |
|---|---|
| Density | 1.4655 (rough estimate) |
| refractive index | 1.5690 (estimate) |
| storage temp. | 0-6°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.82(at 25℃) |
| color | Pale Brown to Light Brown |
| Water Solubility | 5g/L(room temperature) |
| Merck | 13,862 |
| BRN | 2697523 |
| Major Application |
agriculture environmental |
| InChI | 1S/C8H10N2O4S/c1-14-8(11)10-15(12,13)7-4-2-6(9)3-5-7/h2-5H,9H2,1H3,(H,10,11) |
| InChIKey | VGPYEHKOIGNJKV-UHFFFAOYSA-N |
| SMILES | COC(=O)NS(=O)(=O)c1ccc(N)cc1 |
| LogP | -0.270 |
| EWG's Food Scores | 1 |
| FDA UNII | 0Y5ASM7P5S |
| NIST Chemistry Reference | Asulam(3337-71-1) |
| EPA Substance Registry System | Asulam (3337-71-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P273-P391-P501 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| RTECS | FD1190000 |
| HS Code | 29350090 |
| Storage Class | 13 - Non Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Hazardous Substances Data | 3337-71-1(Hazardous Substances Data) |
| Toxicity | LD50 in rats, mice, dogs, rabbits (mg/kg): >5000, >5000, >5000, >2000 orally; in rats (mg/kg): >1200 dermally (Brockelsby) |
Asulam price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 45329 | Asulam PESTANAL | 3337-71-1 | 250mg | $27.5 | 2022-05-15 | Buy |
| Cayman Chemical | 37902 | Asulam ≥98% | 3337-71-1 | 100mg | $29 | 2026-04-30 | Buy |
| TRC | TRC-A788750-500MG | Asulam | 3337-71-1 | 500mg | $85 | 2026-06-03 | Buy |
| TRC | TRC-A788750-1G | Asulam | 3337-71-1 | 1g | $111 | 2026-06-03 | Buy |
| TRC | TRC-A788750-10G | Asulam | 3337-71-1 | 10g | $780 | 2026-06-03 | Buy |
Asulam Chemical Properties,Uses,Production
Description
Asulam is a sulfonamide and can be formulated as a sodium salt. It is very water soluble and is a very systemic herbicide following foliar and root uptake, owing to its physicochemical properties (Table 1). The Log P (Kow) of 1.01 and pKa of 4.82 are optimal for phloem mobility in the plant (4). These properties contribute to the herbicidal effectiveness against perennial weeds where translocation to underground meristematic organs is essential for effective control.
Chemical Properties
Light Brown Solid
Uses
Carbamate herbicide; folic acid biosynthesis inhibitor.
Uses
Herbicide.
Uses
Systemic, pre- and postemergence herbicide used to control several perennial grasses and certain broad-leaved weeds such as brackenfern, crabgrass, itchgrass, paragrass, tansy ragwort, and wild mustard, in alfalfa, uncropped land, certain ornamentals and turf.
Definition
ChEBI: A carbamate ester that is methyl carbamate substituted by a (4-aminophenyl)sulfonyl group at the nitrogen atom.
Production Methods
Asulam is commercially produced by reacting sulfanilamide with dimethyl sulphate and methyl chloroformate. The synthesis begins with sulfanilamide, which undergoes methylation using dimethyl sulphate to introduce a methyl group on the nitrogen atom. This intermediate is then reacted with methyl chloroformate to form asulam.
Health Hazard
Low order of toxicity; no adverse effect onskin reported; ingestion of large dose couldproduce cholinergic effects.
LD50 oral (rat): 2000 mg/kg.
Mechanism of action
Selective system action, absorbed by leaves, shoots and roots. Inhibition of dihydropterate synthase causing slow chlorosis.
Pharmacology
Asulam-induced growth inhibition of carrot cell cultures was reversed by 4-aminobenzoic acid (8), and depletion of folate derivatives in treated plants (7) provides further evidence that the synthesis of folic acid is the primary target of asulam. Furthermore, asulam is structurally related to sulfonilamide and to sulfonamide antimicrobial drugs, which are competitive inhibitors of 7,8-dihydropteroate synthase (DHPS) (5,9).
Environmental Fate
Soil. It is not persistent in soils since its half-life is approximately 6–14 days (Hartley
and Kidd, 1987). The short persistence time is affected by soil temperature and moisture
content. The half-life of asulam in a heavy clay soil having a moisture content of 34%
and maintained at 20°C was 7 days (Smith and Walker, 1977). In soil, sulfanilamide was
reported as a product of hydrolysis. In non-sterile soils, this compound further degraded
to unidentifiable products (Smith, 1988) which may include substituted anilines (Bartha,
1971).
Photolytic. The reported photolytic half-lives for asulam in water at pH 3 and 9 were
2.5 and 9 days, respectively (Humburg et al., 1989)
Chemical/Physical. Forms water-soluble salts (Hartley and Kidd, 1987). When heated
to 75°C, asulam decomposed to sulfanilic acid, carbamic acid and sulfanilamide. At 90°C,
4-nitro- and 4-nitrosobenzene sulfonic acids were released (Rajagopal et a
Pesticide Type
Herbicide
Asulam Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
