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(-)-MDL 100907

(-)-MDL 100907 Structure
(-)-MDL 100907 structure
CAS No.
175673-57-1
Chemical Name:
(-)-MDL 100907
Synonyms
M 100009;MDL 100009;(S)-MDL 100907;(?)-Volinanserin;MDL 100009(MDL100009);MDL 100009, 10 mM in DMSO;MDL 100009 - MDL 100907, (S)-(-)-;(S)-(2,3-Dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol;4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αS)-;4-PIPERIDINEMETHANOL, A-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-, (AS)-
CBNumber:
CB32454075
Molecular Formula:
C22H28FNO3
Molecular Weight:
373.465
MDL Number:
MFCD10565916
MOL File:
175673-57-1.mol
MSDS File:
SDS
Last updated:2026-05-11 19:39:08
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(-)-MDL 100907 Properties

Boiling point 499.4±45.0 °C(Predicted)
Density 1.150±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Ethanol: Soluble: =10 mg/ml
pka 13.93±0.20(Predicted)

(-)-MDL 100907 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 42955 (−)-Volinanserin ≥98% 175673-57-1 1mg $83 2026-04-30 Buy
Cayman Chemical 42955 (−)-Volinanserin ≥98% 175673-57-1 5mg $186 2026-04-30 Buy
Cayman Chemical 42955 (−)-Volinanserin ≥98% 175673-57-1 10mg $330 2026-04-30 Buy
Cayman Chemical 42955 (−)-Volinanserin ≥98% 175673-57-1 25mg $722 2026-04-30 Buy
ChemScene CS-0142264 (S)-Volinanserin 99.84% 175673-57-1 1mg $126 2026-06-04 Buy
Product number Packaging Price Buy
42955 1mg $83 Buy
42955 5mg $186 Buy
42955 10mg $330 Buy
42955 25mg $722 Buy
CS-0142264 1mg $126 Buy

(-)-MDL 100907 Chemical Properties,Uses,Production

Uses

(S)-Volinanserin is an isform of Volinanserin (HY-14940). Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity.

in vivo

Volinanserin (MDL 100907; 0.008-2.0 mg/kg, i.p.) significantly decreases d-amphetamine-stimulated locomotor activity in mice, with an ED50 of 0.3 mg/kg, but shows no obvious reduction in the base-line locomotor activity in mice. Volinanserin produces atalepsy with an ED50 of 10-50 mg/kg in rats. Volinanserin does not reduces apomorphine-induced stereotypies or produces catalepsy in rats[1]. Volinanserin (M100907) combined with MK-801 significantly decreases reinforcers at 1 μg/kg, but dose-dependently (10, 100 μg/kg) antagonizes the disruptive effect of MK-801 in rats via i.p. administration. Volinanserin (6.25 μg/kg) enhances the antidepressant-like action of Desipramine (HY-B1272A) in rats performing under a DRL 72-s schedule, and elevates the antidepressant-like effect of Tranylcypromine (HY-17447)[2].

References

[1] Sorensen SM, et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther. 1993 Aug;266(2):684-91. PMID:8102646
[2] Ardayfio PA, et al. The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. J Pharmacol Exp Ther. 2008 Dec;327(3):891-7. DOI:10.1124/jpet.108.143370
[3] TIMO HEINRICH DR. 1-(1-Phenethylpiperidin-4-yl)-1-phenylethanols as Potent and Highly Selective 5-HT2A Antagonists[J]. ChemMedChem, 2006, 1 2: 245-255. DOI: 10.1002/cmdc.200500023

(-)-MDL 100907 synthesis

332-42-3
311348-76-2
175673-57-1
Synthesis of (-)-MDL 100907 from 1-(2-Bromoethyl)-4-fluorobenzene and 4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-, (αS)-

(-)-MDL 100907 Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-MDL 100907 Suppliers

Global( 24)Suppliers
Supplier Tel Email Country ProdList Advantage
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9796 55
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Tianjin Nuokang Pharmaceutical Technology Co., Ltd. 022-23989838 13810451150 44766350@qq.com China 2725 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Supplier Advantage
VDM Biochemicals 64
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
TargetMol Chemicals Inc. 58
InvivoChem 58
Tianjin Nuokang Pharmaceutical Technology Co., Ltd. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58

View Lastest Price from (-)-MDL 100907 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MDL 100009 pictures 2026-08-08 MDL 100009
175673-57-1
 $56.00-187.00 98.96% 10g TargetMol Chemicals Inc.
  • MDL 100009 pictures
  • MDL 100009
    175673-57-1
  • $56.00-187.00
  • 98.96%
  • TargetMol Chemicals Inc.

(-)-MDL 100907 Spectrum

(-)-MDL 100907(175673-57-1)1HNMR

175673-57-1((-)-MDL 100907)Related Search:

ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL (-)-MDL 100907 (-)-MDL 105725 (+/-)-alpha-(2,3-Dimethoxy-phenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine-methanol ATENOLOL-D7
(+/-)-LY367385

1of2

(S)-(2,3-DIMETHOXY-PHENYL)-(1-[2-(4-FLUORO-PHENYL)-ETHYL]-PIPERIDIN-4-YL)-METHANOL (S)-MDL 100907 4-PIPERIDINEMETHANOL, A-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-, (AS)- M 100009 MDL 100009 MDL 100009 - MDL 100907, (S)-(-)- 4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αS)- (S)-(2,3-Dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol MDL 100009(MDL100009) MDL 100009, 10 mM in DMSO (?)-Volinanserin 175673-57-1 Selective 5-HT2A antagonist.