5-Bromo-2-chlorobenzyl amine
- CAS No.
- 1096296-85-3
- Chemical Name:
- 5-Bromo-2-chlorobenzyl amine
- Synonyms
- (5-Bromo-2-chlorophenyl);5-Bromo-2-chlorobenzyl amine;(5-BroMo-2-chlorophenyl)MethanaMine;BenzeneMethanaMine, 5-broMo-2-chloro-;(5-Bromo-2-chlorophenyl)methanamine - [B90087]
- CBNumber:
- CB32490837
- Molecular Formula:
- C7H7BrClN
- Molecular Weight:
- 220.49
- MDL Number:
- MFCD12026286
- MOL File:
- 1096296-85-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Storage Class | 11 - Combustible Solids |
5-Bromo-2-chlorobenzyl amine price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS33982 | 5-Bromo-2-chlorobenzylamine 95% | 1096296-85-3 | 1g | $80 | 2026-06-04 | Buy |
| Activate Scientific | AS33982 | 5-Bromo-2-chlorobenzylamine 95% | 1096296-85-3 | 5g | $145 | 2026-06-04 | Buy |
| Activate Scientific | AS33982 | 5-Bromo-2-chlorobenzylamine 95% | 1096296-85-3 | 25g | $967 | 2026-06-04 | Buy |
| Matrix Scientific | 074595 | 5-Bromo-2-chlorobenzylamine | 1096296-85-3 | 1.00g | $347 | 2026-05-18 | Buy |
| Matrix Scientific | 074595 | 5-Bromo-2-chlorobenzylamine | 1096296-85-3 | 5.00g | $899 | 2026-05-18 | Buy |
5-Bromo-2-chlorobenzyl amine Chemical Properties,Uses,Production
Synthesis
478374-91-3
1096296-85-3
The synthesis of 5-bromo-2-chlorobenzylamine (3) as the target was carried out as follows: azide 2 (2.4 g, 9.76 mmol) was dissolved in THF (60 mL) at 0 °C, and triphenylphosphine (2.86 g, 10.90 mmol, 1.12 eq.) was slowly added while stirring. After addition, the mixture was continued to stir at 0 °C for 10 min, followed by overnight stirring at room temperature. Complete consumption of the raw material was confirmed by TLC analysis (unfolding agent: EtOAc-hexane, 1:20). Subsequently, ammonium hydroxide solution (10 mL) was added drop-wise and after stirring for 30 minutes, 1N NaOH solution (20 mL) was added and the resulting mixture was continued to be stirred for 2 hours at room temperature. After the reaction was completed, it was diluted by adding ether (100 mL) and water (80 mL). The mixture was adjusted to acidity (pH 2) by slowly adding 4N H2SO4 solution dropwise. The aqueous layer was separated and adjusted to basicity with 4N NaOH solution, followed by extraction with DCM (2 x 100mL). The organic layers were combined, dried with MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: MeOH-DCM, 1:20) to afford the target product 3 as a colorless liquid (1.45 g, 67% yield). The product was analyzed by LC-MS showing: retention time (R t) 3.67 min, mass-to-charge ratio (m/e) 221.1,205.1; 1H NMR (CDCl3) δ 7.64 (s, 1H), 7.40 (dd, 1H), 7.28 (d, 1H), 4.02 (s, 2H), 1.58 (s, broad peak, 2H, NH2).
References
[1] Patent: WO2009/62059, 2009, A2. Location in patent: Page/Page column 39-40
5-Bromo-2-chlorobenzyl amine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
5-Bromo-2-chlorobenzyl amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4538 | 58 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9985 | 58 |
