4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol
- CAS No.
- 17759-30-7
- Chemical Name:
- 4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol
- Synonyms
- (4-MethylaMino-2-MethanethiopyriMidin-5-yl)Methanol;4-(MethylaMino)-2-(Methylthio)-5-pyriMidineMethanol;4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol;5-Pyrimidinemethanol, 4-(methylamino)-2-(methylthio)-;(4-MethylaMino-2-MethylsulfanylpyriMidin-5-yl)Methanol;(4-(MethylaMino)-2-(Methylthio )pyriMidin-5-yl)Methanol;(4-MethylaMino-2-Methanesulfanyl-pyriMidin-5-yl)-Methanol
- CBNumber:
- CB32510337
- Molecular Formula:
- C7H11N3OS
- Molecular Weight:
- 185.25
- MDL Number:
- MFCD16293863
- MOL File:
- 17759-30-7.mol
- MSDS File:
- SDS
| Melting point | 155-157 °C |
|---|---|
| Boiling point | 398.9±32.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform, Dichloromethane, DMSO, Methanol |
| form | Solid |
| pka | 13.16±0.10(Predicted) |
| color | White |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M286900-50MG | 4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol | 50mg | $129 | 2026-06-03 | Buy | |
| TRC | TRC-M286900-250MG | 4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol | 250mg | $320 | 2026-06-03 | Buy | |
| TRC | TRC-M286900-100MG | 4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol | 100mg | $217 | 2026-06-03 | Buy | |
| Usbiological | 016502 | 4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol | 17759-30-7 | 100mg | $531 | 2026-06-03 | Buy |
| Matrix Scientific | 126652 | (4-(Methylamino)-2-(methylthio)-pyrimidin-5-yl)methanol | 17759-30-7 | 1.00g | $1044 | 2026-05-18 | Buy |
4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
An intermediate in the preparation of antitumor agents and tyrosine kinase inhibitors
Synthesis
76360-82-2
17759-30-7
The general procedure for the synthesis of (4-methylamino-2-methanesulfonyl-pyrimidin-5-yl)-methanol from ethyl 4-methylamino-2-methylthio-5-pyrimidinecarboxylate was as follows: lithium aluminium hydride (11.48 g, 302 mmol) was suspended in 600 mL of anhydrous tetrahydrofuran (THF) in a 2 L three-necked flask fitted with an overhead stirrer, protected by argon gas. Another 250 mL round-bottomed flask was taken and ethyl 4-methylamino-2-methylthio-5-pyrimidine carboxylate (43.71 g, 0.192 mol) was dissolved in 200 mL of anhydrous THF and transferred through a cannula to a 250 mL addition funnel. The pyrimidine solution was slowly added dropwise to the lithium aluminum hydride suspension at room temperature for a controlled time of 30 minutes. After the dropwise addition was completed, the reaction was continued with stirring for 1 hour. Subsequently, 25 mL of water was carefully added dropwise over 30 minutes to quench the reaction. Next, 25 mL of 15% (w/v) aqueous sodium hydroxide solution and 75 mL of water were added sequentially, at which point the reaction mixture faded from a light green color and formed a light green slurry, and stirring was continued for 1 hour. Upon completion of the reaction, the precipitated aluminum salt was removed by vacuum filtration and the solid was washed well with ethyl acetate (EtOAc). The filtrate was concentrated to give a light yellow slurry. The slurry was suspended in 250 mL of a 25% EtOAc/hexane solvent mixture and the colorless solid was separated by vacuum filtration. After vacuum drying, 31.9 g (90% yield) of the target product (4-methylamino-2-methylthio-pyrimidin-5-yl)-methanol was obtained, and the spectral data were consistent with those reported in the literature.
References
[1] Patent: WO2004/63195, 2004, A1. Location in patent: Page 53-54
[2] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 355
[3] Patent: WO2008/33999, 2008, A2. Location in patent: Page/Page column 88
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2255 - 2265
[5] Patent: US2003/207900, 2003, A1. Location in patent: Page/Page column 15
4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol Preparation Products And Raw materials
Raw materials
Preparation Products
4-(Methylamino)-2-(methylthio)pyrimidine-5-methanol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2993 | 60 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189;18621755571 | mychess007@163.com | China | 1994 | 55 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Tcichem, Inc. | 13918644899 | 81587635@qq.com | China | 1994 | 55 |
| Shanghai Brain Biotechnology Co., Ltd. | 13564638271 | shhjiang1977@163.com | China | 2983 | 55 |
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