(4-Amino-2-(methylthio)pyrimidin-5-yl)methanol
- CAS No.
- 588-36-3
- Chemical Name:
- (4-Amino-2-(methylthio)pyrimidin-5-yl)methanol
- Synonyms
- Methioprim;(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)ME...;4-AMINO-2-(METHYLTHIO)-5-PYRIMIDINEMETHANOL;5-Pyrimidinemethanol, 4-amino-2-(methylthio)-;4-Amino-2-(methylthio)-5-pyrimidinyl]methanol;(4-Amino-2-(methylthio)pyrimidin-5-yl)methanol;4-AMINO-2-METHYLMERCAPTO-PYRIMIDINE-4-CARBINOL;4-AMINO-5-HYDROXYMETHYL-2-(METHYLTHIO)PYRIMIDINE;(4-AMINO-2-METHYLSULFANYL-PYRIMIDIN-5-YL)-METHANOL;(4-azanyl-2-methylsulfanyl-pyrimidin-5-yl)methanol
- CBNumber:
- CB3387753
- Molecular Formula:
- C6H9N3OS
- Molecular Weight:
- 171.22
- MDL Number:
- MFCD08236793
- MOL File:
- 588-36-3.mol
- MSDS File:
- SDS
| Melting point | 126-127° |
|---|---|
| Boiling point | 408.6±30.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.08±0.10(Predicted) |
| color | Off-White to Pale Yellow |
| FDA UNII | 6213O32QRM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 29335990 |
(4-Amino-2-(methylthio)pyrimidin-5-yl)methanol price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS17417 | 4-Amino-2-methylthio-5-pyrimidinemethanol 97% | 588-36-3 | 1g | $57 | 2026-06-04 | Buy |
| Activate Scientific | AS17417 | 4-Amino-2-methylthio-5-pyrimidinemethanol 97% | 588-36-3 | 5g | $204 | 2026-06-04 | Buy |
| Matrix Scientific | 071115 | (4-Amino-2-(methylthio)pyrimidin-5-yl)methanol | 588-36-3 | 5.00g | $1035 | 2026-05-18 | Buy |
| Synthonix | A10636 | 4-Amino-2-methylthio-5-pyrimidinemethanol 97.0% | 588-36-3 | 1g | $34 | 2026-05-06 | Buy |
| Synthonix | A10636 | 4-Amino-2-methylthio-5-pyrimidinemethanol 97.0% | 588-36-3 | 5g | $100 | 2026-05-06 | Buy |
(4-Amino-2-(methylthio)pyrimidin-5-yl)methanol Chemical Properties, Uses, Production
Chemical Properties
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL is white cryst powder
Uses
Tumor antagonist in mice.
Uses
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL is an intermediate used in the synthesis of Thiamine (T344185). Also, used for the preparation of pyridopyrimidines and naphthyridines as inhibitors of Akt kinase for the treatment of cancer.
Synthesis
776-53-4
588-36-3
General procedure for the synthesis of 2-(methylthio)-4-aminopyrimidine-5-carboxylic acid from ethyl 2-(methylthio)-4-aminopyrimidine-5-carboxylate: ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate (72.3 g, 339 mmol) was dissolved in tetrahydrofuran (THF, 900 mL) and the solution was cooled to 0 °C. A solution of LiAlH4 (2 M in THF, 195 mL, 390 mmol) was added slowly and dropwise over 1 hour. The reaction mixture was kept stirred at 0 °C for 2 h, then allowed to warm slowly to room temperature and continued stirring overnight. Upon completion of the reaction, the mixture was again cooled to 0 °C and water (15 mL), 20% aqueous potassium hydroxide solution (15 mL) and water (30 mL) were carefully added in turn to quench the reaction. The resulting mixture was stirred for 1 hour. Subsequently, it was dried with anhydrous magnesium sulfate (MgSO4), filtered, and the filtrate was concentrated under reduced pressure and finally dried under vacuum to afford the target product 2-methylthio-4-aminopyrimidine-5-methanol (55.85 g, 96% yield). Mass spectrometry (MS) analysis showed m/z: 172.1 ([M + H]+).
References
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2371 - 2387
[2] Patent: WO2013/134243, 2013, A1. Location in patent: Page/Page column 16
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 10, p. 4165 - 4179
[4] Patent: WO2014/151682, 2014, A1. Location in patent: Page/Page column 57; 58
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 578 - 599
(4-Amino-2-(methylthio)pyrimidin-5-yl)methanol Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1875 | 55 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
View Latest Price from (4-Amino-2-(methylthio)pyrimidin-5-yl)methanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
588-36-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-08-09 | (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
588-36-3
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
588-36-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
588-36-3
- $8.80
- 97%-99%
- Career Henan Chemical Co
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